Ocena aktywnosci gamma-glutamylotransferazy i stezenia glutationu zredukowanego w watrobie szczura w ostrym zatruciu chlorfenwinfosem

• Autorzy: Lukaszewicz-Hussain A. , Moniuszko-Jakoniuk J.
• Języki publikacji: PL

Abstrakty

PL

EN

The aim of this paper was estimation the GGT activity and GSH concentration in the liver of rats intoxicated with chlorfenvinphos. The experiment was conducted on male Wistar rats divided into three groups: control-which received oil and examined - receiving oil solution of chlorfenvinphos in dose of 0.5LD50 and 0.1 LD50. At the 1st, 24th and 48th hour after intoxication an activity of enzyme was determined. The GGT activity increased after 48th hour of intoxication with the lower dose of insecticide and after 1st, 24th and 48th with higher dose. The GSH concentration increased at the 1st, 24th and 48th hour of intoxication with chlorfenvinphos at dose 0.1 LD50 and at the 24th hour of intoxication with chlorfenvinphos at dose 0.5 LD50. We suppose that increase in the liver GGT activity can result from disturbance in hepatic function. This increase can influence on the reduced glutathione level.

Słowa kluczowe

PL

szczury; insektycydy fosforoorganiczne; chlorfenwinfos; toksykologia; glutation; gamma-glutamylotransferaza; zatrucia pokarmowe; watroba

EN

rat; chlorfenvinphos; toxicology; glutathione; gamma-glutamyltransferase; food poisoning; liver

• Wydawca: -
• Czasopismo: Roczniki Państwowego Zakładu Higieny
• Rocznik: 2002
• Tom: 53
• Numer: 2
• Opis fizyczny: s.119-124,tab.,bibliogr.

Twórcy

autor

Lukaszewicz-Hussain A.

• Akademia Medyczna, Bialystok

autor

Moniuszko-Jakoniuk J.