Wyniki wyszukiwania - AGRO

1

The effect of physical exercise on glutathione-dependent erythrocytes' antioxidant system

100%

Hubner-Wozniak E., Lutoslawska G.

Polish Journal of Environmental Studies

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1998

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tom 07

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nr 6

2

Membrane transport of glutathione conjugates

88%

Bartosz G.

Current Topics in Biophysics

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1994

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tom 18

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nr 2

3

Role of nitric oxide and reduced glutathione and their implication on typhoid

75%

Haque S. S.

Journal of Biology and Earth Sciences

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2012

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tom 02

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nr 2

4

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Response of Berberis thunbergii to heavy metals under urban pollution

75%

Chadzinikolau T., Kozlowska M., Mleczek M.

Dendrobiology

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2010

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tom 64

Increasing pollution of the environment causedby heavy metals is becoming a significant problem in developing cities. Species andcultivars of plants for urban plantings shouldexhibit tolerance to these pollutants, andwhat is even more significant, through their absorption they shouldred uce the level of environmental contamination. The aim of the research was to determine whether Berberis thunbergii (DC.), which was grown in the immediate vicinity of roads, developed mechanisms limiting harmful effects of accumulating heavy metals. The mechanism for heavy metal resistance, involving the generation of phytochelatins (PCs), was investigatedin relation to As, Cd, Cr, Co, Cu, Hg, Ni, Pb andZn accumulation. Levels of thiols, i.e. glutathione (GSH) andphytochelatins (PCs), increasedin plants grown in pollutedareas in the city of Poznań in comparison to a residential site (control) and it was related to the activity of phytochelatin synthase (PC-synthase) andthe accumulation of metals. The results indicate that in Berberis thunbergii growing in the polluted urban environment a defense mechanism adapting the plant to potentially adverse conditions was initiated.

5

Changes in the level of non-enzymatic antioxidants in leaves of Phaseolus coccineus (L.) plants under heavy metal stress

75%

Patrzylas P., Wojcik M., Skorzynska-Polit E.

BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology

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2015

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tom 96

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nr 1

6

Cadmium-treated Arabidopsis thaliana reveal a regulatory role of glutathione in superoxide dismutase

75%

Jozefczak M., Keunen E., Schat H., Remans T., Vangronsveld J., Cuypers A.

BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology

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2013

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tom 94

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nr 2

7

Carbon synthetized by RF PACVD method enhances the activity of antioxidants

75%

Niemiec T., Szmidt M., Kruk-Roszkowska A., Sawosz-Chwalibog E., Mitura K.

Annals of Warsaw University of Life Sciences - SGGW. Animal Science

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2013

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tom 52

The aim of the presented study was to evaluate the reductive activity of antioxidants in the presence of carbon manufactured by Radio Frequency Plasma Activated Chemical Vapor Deposition method (RF PACVD). 2,2-diphenyl-1-picrylhydrazyl (DPPH) method was employed to estimate antioxidants reductive potential. Based on the experimental results, the antioxidant activity of carbon colloid was not confirmed. Nevertheless the reductive activity of antioxidants measured in time manner, in the presence of carbon, was significantly elevated comparing to the antioxidants alone. The presented results suggest that the surface of carbon syn-thetized by RF PACVD method suspended in water, creates more friendly reductive environment for antioxidants with hydroxyl groups (ascorbic acid - AA and butylated hydroxyanisole - BHA) then with sulfhydryl groups (glutathione - GSH).

8

Role of glutathione and glutathione S-transferase in lead tolerance and bioaccumulation by Dodonaea viscosa (L.) Jacq

75%

Rojas-Loria C. C., Favela-Torres E., Gonzales-Marquez H., Volke-Sepulveda T. L.

Acta Physiologiae Plantarum

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2014

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tom 36

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nr 09

Glutathione (GSH) plays a central role in the plant tolerance against the toxic effects of metals. It is a key antioxidant and acts as a cofactor for glutathione S-transferase (GST). The main objective of this study was to determine the Pb tolerance and bioaccumulation by Dodonaea viscosa (L.) Jacq. and their relation to GSH production and GST activity. The relationship between the Pb tolerance and bioaccumulation by D. viscosa and the effect of the exposure time on the GSH production or the GST activity was assessed in trials with perlite under different Pb treatments. D. viscosa showed a remarkable tolerance to Pb [half-inhibitory concentration (IC₅₀) = 2,797 mg kg⁻¹] and accumulated up to 11,428 mg Pb kg⁻¹ in dry roots with a limited translocation to shoots without any signs of phytotoxicity after 105 days of exposure. The stress caused by the fast Pb uptake rate (489 mg kg⁻¹ day⁻¹) during the first 10 days of exposure was strongly correlated to increased GSH contents (~1.3-fold) and GST activities (~3.6-fold) in both shoots and roots. The results indicate that the Pb stress triggered a defense mechanism that involved increased contents of GSH and GST activities, suggesting that both variables are involved in the tolerance of D. viscosa against Pb toxicity.

9

The role of glutathione in mammalian gametes

75%

Luberda Z.

Reproductive Biology

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2005

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tom 05

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nr 1

10

Acceleration of transformation of thiyl radicals to disulfides by methemoglobin. Antioxidant function of methemoglobin

75%

Stepuro I., Silinevich I., Sokolovskaya S., Naumjk E.

Current Topics in Biophysics

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1994

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tom 18

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nr 2

11

The role of reduced glutathione in bile formation in sheep

75%

Bobowiec R., Kosior-Korzecka U., Martelli F., Sighieri C.

Polish Journal of Veterinary Sciences

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1999

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tom 02

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nr 1

The present study reports the investigation on the influence of reduced glutathione (GSH) on bile secretion in 4 canulated sheep during constant intraduodenal infusion of bile alone, bile with sodium taurocholate (TCHNa) or bile with sodium deoxycholate (DCHNa). Infusions of bile alone and bile with TCHNa or DCHNa brought about an increase in the bile salts secretion from 0.05 ± 0.01 (μM/min/kg to the value of 0.12 ± 0.03, 0.22 ± 0.07 and 0.32 ± 0.08 μM/min/kg, respectively. It was shown that the administration of GSH during the infusion of both bile alone and bile+bile salts slightly but significantly (p < 0.05) lowered bile salts secretion. At the same time both bile with glutathione and bile+bile salts+glutathione increased the bile flow significantly (p < 0.05) as compared to that found after infusions without glutathione. After the i.v. administration of GSH, the volume of the bile increased to a lesser extent than it did with bile+TCHNa or, especially, with bi- le+DCHNa infusions. The concentration of glutathione in the bile was the highest during the infusion of bile+DCHNa (671.18 ng/ml), lower during the infusion of bile+TCHNa (471.40 ng/ml) and the lowest during the infusion of bile alone. Although the bile salts secretion decreased during the simultaneous infusion of the bile with bile salts and glutathione, there was an increase in the bile flow. Therefore, we concluded that some bile acid independent fraction was secreted into the bile and that the fraction was dependent on GSH secretion at the level of canaliculi.

12

The activity of red blood cell glutathione reductase and glucose-6-phosphate dehydrogenase, and level of reduced glutathione after physical exercise and training

75%

Spodaryk K.

Polish Journal of Environmental Studies

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1998

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tom 07

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nr 6

13

A highly efficient method for determination of some amino acids and glutahione by liquid chromatography

75%

Czauderna M., Kowalczyk J., Niedzwiedzka K. M., Wasowska I.

Journal of Animal and Feed Sciences

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2003

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tom 12

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nr 1

14

Glutathione: its role in the detoxication of reactive oxygen and environmental chemicals

75%

Parke D. V., Piotrowski J. K.

Acta Poloniae Toxicologica

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1996

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tom 04

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nr 1

15

Transport of organic anions by multidrug resistance-associated protein in the erythrocyte

75%

Rychlik B., Pulaski L., Sokal A., Soszynski M., Bartosz G.

Acta Biochimica Polonica

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2000

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tom 47

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nr 3

The active transport of oxidized glutathione and glutathione S-conjugates has been demonstrated for the first time in erythrocytes and this cell remained the main subject of research on the glutathione S-conjugate pump for years. Further studies identified the glutathione S-conjugate pump as multidrug resistance-associated protein (MRP). Even though cells overexpressing MRP and isolated MRP provide useful information on MRP structure and function, the erythrocyte remains an interesting model cell for studies of MRP1 in its natural environment, including the substrate specificity and ATPase activity of the protein.

16

Biochemical indicators of environmental contamination with heavy metals

75%

Orzechowski S., Kwinta J., Gworek B., Bielawski W.

Polish Journal of Environmental Studies

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1997

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tom 06

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nr 6

Changes in activity of one of the most important enzymes of nitrogen compound metabolism - glutamate dehydrogenase (GDH EC 1.4.1.2-4) under the conditions of variable concentrations of Cd2+, Zn2+, Pb2+ were investigated. Dry matter increase and glutathione (GSH) levels varying under these conditions were also analyzed. The obtained results show a close relationship between the concentration of the investigated metal ions, especially Cd2+, and the metabolism of primary amino acids. The increase of the heavy metal concentration resulted in a many-fold GDH activity increase, significant decrease of the seedling mass, and lowering of the GSH level. The increase of GDH activity may attest to the important role of that enzyme in catabolic processes intensified under these conditions, or to the increasing importance of the reductive amination of 2-oxoglutarate in the states of physiological stress caused by the presence of heavy metals. The observed relationship concerns the plant's photosynthetizing organs rather than its root system.

17

Sulfurtransferase activity and sulfur compound content in Rana temporaria brain following hibernation

75%

Wrobel M.

Acta Neurobiologiae Experimentalis

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2001

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tom 61

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nr 1

18

The reactivity of the lysosomal system, modified by reduced glutathione in subcellular fractions of the mouse kidney

75%

Jozwik A., Sliwa-Jozwik A., Fronczyk W., Kolataj A.

Cellular and Molecular Biology Letters

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2002

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tom 07

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nr Suppl.

19

Effect of reduced glutathione [GSH] on activity of lysosomal system in subcellular fractions of mouse kidney

75%

Sliwa-Jozwik A., Jozwik A., Fronczyk W., Guszkiewicz A., Kolataj A.

Animal Science Papers and Reports

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2004

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tom 22

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nr 2

Investigated was the effect of intraperitoneal injections (twice daily for seven consecutive days) of reduced glutathione (GSH) on activity of selected lysosomal hydrolases (alanine aminopeptidase, leucine aminopeptidase, cathepsins D and L, acid phosphatase and N-acetyl-β-D-glucosaminidase) in lysosomal, microsomal and cytosol fractions of mouse kidney. Most notable effect of exogenous GSH on the activity of the enzymes considered was observed in lysosomal, while the least in microsomal fraction. After a series of GSH injections the activity of enzymes increased significantly mainly In lysosomal fraction. It is assumed that the increase in activity of lysosomal enzymes following the GSH injections results from a physiological response of renal cells to this antioxidant.

20

There is no evidence for the existence of complex formation between doxorubicin and glutathione

75%

Marszalek M., Bartosz M., Bartosz G.

Cellular and Molecular Biology Letters

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2003

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tom 08

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nr 2

Doxorubicin is co-transported with glutathione by several multidrug resistance proteins (MRPs). In order to check whether weak non-covalent aggregates between doxorubicin and glutathione can be formed, which might be substrates for the transporter, the effect of glutathione on the partition coefficient of doxorubicin was studied. No evidence of an effect of glutathione (at levels up to 20 mM) on the partition coefficient of doxorubicin was found in the pH range of 4.0-7.4. These results indicate that non-covalent doxorubicin-glutathione complexes do not form.

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