Selenoenzymes in animal tissues after supplementation with SELOL

• Autorzy: Zagrodzki P , Bik D. , Fitak B.A. , Suchocki P. , Niemczuk K.
• Języki publikacji: EN

Abstrakty

EN

The aim of the present work was to examine whether SELOL influences the activities of selenoenzymes. The activity of the following selenoenzymes was measured in plasma, blood, and various animal tissues: plasma glutathione peroxidase (plGSHPx), cytosolic glutathione peroxidase (cGSHPx), type I and type II iodothyronine deiodinases (ID-I, ID-II), and thioredoxin reductase (THRR). Eleven sheep were randomly assigned to either study group – supplemented with SELOL (5 animals) - or control group maintained on standard diet (6 animals). The experiment lasted for one month. The above selenoenzyme activity was not influenced in the adrenals, brain, kidneys, liver, pituitary gland, spleen, and thyroid gland by SELOL administration. The results indicate that the pharmacological action of SELOL is more complex than for "classical" selenium containing compounds and further speciation study is necessary to clarify its biological functions.

Słowa kluczowe

EN

diet; iodothyronine deiodinase; sheep; animal; SELOL; thioredoxin reductase; animal tissue; supplementation; organoselenium compound; selenium; glutathione peroxidase

• Wydawca: -
• Czasopismo: Bulletin of the Veterinary Institute in Puławy
• Rocznik: 2000
• Tom: 44
• Numer: 2
• Opis fizyczny: p.215-220

Twórcy

autor

Zagrodzki P

• Jagiellonian University Collegium Medicum, Krakow, Poland

autor

Bik D.

autor

Fitak B.A.

autor

Suchocki P.

autor

Niemczuk K.

Bibliografia

• 1. Arthur J.R., Nicol F., Boyne R., Allen K.G.D., Hayes J.D., Beckett G.J.: Old and new roles for selenium. In Trace Substances in Environmental Health XXI. Edited by Hemphill D.D. University of Missouri, USA 1987, pp. 487-498.
• 2. Arthur J.R., Nicol F., Hutchinson R.A., Beckett G.J.: The effect of selenium depletion and repletion on the metabolism of thyroid hormones in the rat. J. Inorg. Biochem. 1990, 39, 101-108.
• 3. Beckett G.J., Beddows S.E., Morrice P.C., Nicol F., Arthur J.R.: Inhibition of hepatic deiodination of thyroxine caused by selenium deficiency in rats. Biochem. J. 1987, 248, 443-447.
• 4. Beech S.G., Walker S.W., Beckett G.J., Arthur J.R., Nicol F., Lee D.: Effect of selenium depletion on thyroidal type-I iodothyronine deiodinase activity in isolated human thyrocytes and rat thyroid and liver. Analyst 1995, 120, 827-831.
• 5. Bermano G., Arthur J.R., Hesketh J.E.: Differential regulation of selenoprotein gene expression by selenium supply. In Trace Element in Man and Animals - 9: Proceedings of the Ninth International Symposium on Trace Elements in Man and Animals. Edited by Fisher P.W.F., L' Abbé M.R., Cockell K.A., and Gibson R.S. NRC Research Press, Ottawa, Canada 1995, pp. 47-49.
• 6. Hill K.E., McCollum G.W., Burk R.F.: Determination of thioredoxin reductase activity in rat liver supernatant. Anal. Biochem. 1997, 253, 123.
• 7. Jastrzębski Z., Czyżewska-Szafran H., Fijałek Z., Suchocki P., Fitak B.A.: Toxicity studies of a new selenium compound, Selol, in rats. Drugs Exptl. Clin. Res. 1995, 21, 217-220.
• 8. Judson G.J., Ellis N.J.S., Kempe B.R., Shallow M.: Long-acting selenium treatments for sheep. Aust. Vet. J. 1991, 68, 263-265.
• 9. Lacetera N., Bernabucci U., Ronchi B., Nardone A.: The effect of injectable sodium selenite on immune function and milk production in Sardinian sheep receiving adequate dietary selenium. Vet. Res. 1999, 30, 363-370.
• 10. Mitchell J.H., Nicol F., Beckett G., Arthur J.R.: Selenoenzyme expression in thyroid and liver of second generation selenium- and iodine-deficient rats. J. Mol. Endocrinology 1996, 16, 259-267.
• 11. Morgante M., Begheli D., Pauselli M., Dall'ara P., Capuccella M., Ranucci F.: Effect of administration of vitamin E and selenium during the dry period on mammary health and milk cell counts in dairy ewes. J. Dairy Sci. 1999, 82, 623-631.
• 12. Paglia D., Valentine W.N.: Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. J. Lab. Clin. Med. 1967, 70, 158-169.
• 13. Sawada K., Hummel B.C., Walfish P.G.: Properties of cytosolic components activating rat hepatic 5'[corrected]-deiodination in the presence of NADPH. Biochem. J. 1986, 234, 391-398.
• 14. Tamura T., Stadtman T.C.: A new selenoprotein from human lung adenocarcinoma cells: purification, properties, and thioredoxin reductase activity. Proc. Natl. Acad. Sci. USA 1996, 93, 1006-1011.
• 15. Whanger P.D., Weswig P.H., Schmitz J.A., Oldfield J.E.: Effects of various methods of selenium administration on white disease, glutathione peroxidase and plasma enzyme activities in sheep. J. Anim. Sci. 1978, 47, 1157-1166.
• 16. Zagrodzki P., Nicol F., McCoy M.A., Smyth J.A., Kennedy D.G., Beckett G.J., Arthur J.R.: Iodine deficiency in cattle: compensatory changes in thyroidal selenoenzymes. Res. Vet. Sci. 1998, 64, 209-211.
• 17. Zachara B.A., Trafikowska U., Kaptur M., Kimber C., Lejman H.: The effect of barium selenate injection on selenium concentration and glutathione peroxidase activity in blood of pregnant ewes fed selenium-deficient diet. Biol. Trace Elem. Res. 1992, 32, 415-419.
• 18. Zachara B.A., Trafikowska U., Labedzka H., Mikołajczak J.: Effect of dietary Se intake on blood Se levels and glutathione peroxidase activities in lambs. Small Rumin. Res. 1993, 9, 331-340.