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1

Changes in the fluidity of the lipid monolayer have an effect on spectrin-phospholipid interactions

100%
Diakowski W., Ozimek L., Sikorski A. F.
Cellular and Molecular Biology Letters
|
2002
|
tom 07
|
nr Suppl.
2
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Content available

The role of magnesium in the supposed mechanism of anaesthesia

88%
Kiss S. A., Galbacs Z., Galbacs G.
Journal of Elementology
|
2006
|
tom 11
|
nr 4
The anaesthetic, narcotic effect of magnesium has been discussed since the publication of Meltzer-Auger (1906), but its mechanism has not been clarified. Since then, other investigations have also been performed, but none of the publications has explained the issue. We propose a mechanism analogous to the studies made by Feinstein (1964), who examined organic compounds showing anaesthetic effects. Our view is that magnesium abridges two phospholipids of the opposite sides of the membrane through their phosphate groups. This binding results in membrane rigidity, which makes the ion permeability provided by the ion channel and/or carrier decrease or discontinue, thus the halting of the Na+, K+ and Ca2+ ion flow eventually causes an anaesthetic effect. Another possible pathway is that magnesium ions block the activity of N-methyl-D-aspartate (NMDA) receptor to control the ion channel, which also lowers the permeability of the membrane.
3

Protective action of cholesterol against changes in membrane fluidity induced by methylparathion

88%
Blasiak J.
Acta Biochimica Polonica
|
1993
|
tom 40
|
nr 1
4

High density lipoprotein and low density lipoprotein-mediated changes in cultured human skin fibroblasts

75%
Jozwiak Z., Szosland D., Rozga B.
Cellular and Molecular Biology Letters
|
1996
|
tom 01
|
nr 2
We investigated the effect of native and modified high density lipoprotein (HDL) and low density lipoprotein (LDL) on the viability and the membrane fluidity of normal and diabetic fibroblasts. Under experimental conditions, HDL did not affect the cultured normal cells. Incubation of HDL with diabetic fibroblasts resulted in a negligible decrease in the cell viability and induced an increase in the lipid fluidity at surface of the cell membranes. LDL at the higher concentration reduced the viability both normal and diabetic fibroblasts and also enhanced the fluidity of membrane lipids. The above changes in the fluidity of fibroblast membranes were observed mainly in the presence of native and oxidized lipoproteins and are connected with the differences in the structure of cell membranes and nature of the cytotoxicity of LDL and HDL.
5

Changes in the fluidity of model lipid membranes evoked by the organophosphorus insecticide methylbromfenvinfos

75%
Blasiak J.
Acta Biochimica Polonica
|
1993
|
tom 40
|
nr 1
6

A new phenothiazine derivative alters the fluidity and thermotropic behaviour of phosphatidylcholine model membranes

75%
Wesolowska O., Hendrich A. B., Motohashi N., Michalak K.
Cellular and Molecular Biology Letters
|
2002
|
tom 07
|
nr 2
7

The effect of amphiphilic biocydes contained in a medium on liposome membrane fluidity

75%
Podolak M., Waga S., Przestalski S.
Polish Journal of Environmental Studies
|
1994
|
tom 03
|
nr 2
It was found that quaternary ammonium salt derivatives of glycine ester (GE) admixtures induced increased fluidity of egg yolk lecithin (EYL) liposome membranes (L). The increase depended on chain-lengths of the GEs added and on their concentrations. A maximum fluidity was observed with the 12-carbon atom compound. From considerations concerning the electrostatic interactions in the hydrophilic layer of the liposome mebranes it follows that GEs at low concentrations can induce an increase of binding energy of the layer, while at hihger concentrations the opposite effect can occur.
8

Effect of some lysosomotropic substances on erythrocyte membrane

75%
Kleszczynska H., Luczynski J., Witek S., Przestalski S.
Polish Journal of Environmental Studies
|
1997
|
tom 06
|
nr 6
The effect of N,N-dimethylaminoethyl esters of fatty acids (DM n) on pig red blood cell hemolysis and erythrocyte membrane fluidity has been investigated. In the hemolytic experiments the hemolytic activity of the compounds studied was determined, and was found to increase with alkyl chain length and followed the sequence: DM-15 > DM-13 > DM-11 > DMDA > DM-9. The fluorimetric studies were done using the fluorescent probe TMA-DPH, which allowed us to calculate polarization coefficient P and hence determine relative changes in membrane fluidity induced by the lysosomotropic substances. The compounds of highest hemolytic activity, which have fifteen- and thirteen-carbon-atom alkyl chain (DM-15 and DM-13), significantly affect the erythrocyte membrane fluidity.
9

Electric interactions at the lipid membrane surface

63%
Podolak M., Man D.
Cellular and Molecular Biology Letters
|
2002
|
tom 07
|
nr 4
This work presents the results of an experimental study and of computer simulations concerning electric interactions in the surface layer of egg yolk lecithin (EYL) liposome membranes. The surface layer is formed by EYL polar heads, which possess features of electric dipoles, and positive charged polar heads belonging to admixtures of quaternary ammonium salts (AS). The results of the experimental study are in good agreement with the ones of the computer simulations. It was found that fluidity of the membranes, at a given concentration of AS, obtains the extremal (minimal) value. Similarly, the binding energy of the dipoles-positive charges system behaves like that in computer simulations. Moreover, the locations of the fluidity extremum and those of the binding energy depend on the charge of the AS polar heads as well as on the degree of electric interactions screening by the environment. At a certain optimal value of the screening coefficient, the energy of the system is the lowest (the most negative) and together with the rise in AS charge, the minimum of the energy moves towards its higher concentrations.
10
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EPR-spin labelling measurements of thylakoid membrane fluidity during barely leaf senescence

63%
Jajic I., Sarna T., Wisniewska A., Strzalka K.
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
|
2013
|
tom 94
|
nr 2
11

Choice of technology and the equipment for preparation of water-coal fuel in laboratory conditions

63%
Chernetskaya N., Shvornikova A., Kuschenko A.
Teka Komisji Motoryzacji i Energetyki Rolnictwa
|
2010
|
tom 10
12

In vitro effects of ozone on human erythrocyte membranes: An EPR study

63%
Gornicki A., Gutsze A.
Acta Biochimica Polonica
|
2000
|
tom 47
|
nr 4
The effects of ozone at different concentrations (10, 30, 45 g/m3) on fluidity and thermotropic properties of erythrocyte membranes were investigated by EPR using two spin probes: 5-doxylstearic acid (5-DSA) and 16-doxylstearic acid (16-DSA). The effect of ozone on the erythrocyte membrane fluidity was a dose-dependent process. The ozone at concentration of 10 g/m3 caused rigidization of the membrane while at concentration of 45 g/m3 increased fluidity both on the surface and in the deeper hydrocarbon region of the membrane. Temperature transitions close to the polar heads region (monitored by 5-DSA) were not sensitive to an increase in ozone concentration. In the case of 16-DSA, low temperature thermotropic transition (around 20°C) gradually decreased with the increase of ozone concentration. High temperature transition (around 40°C) significantly differed at the ozone concentration of 10 g/m3 and 45 g/m3, being higher and lower, respectively, as compared to untreated cells. For the ozone concentration of 45 g/m3 the disappearance of the low temperature break and the appearance of two breaks at 37°C and 16°C were observed.
13
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Content available

Predictive food rheology. Factors shaping rheological properties of block cured meat products

63%
Tyszkiewicz S., Olkiewicz M., Wawrzyniewicz M., Borys A., Moch P.
Acta Agrophysica
|
2006
|
tom 07
|
nr 1[132]
14

Effects of cold water swimming on blood rheological properties and composition of fatty acids in erythrocyte membranes of untrained older rats

51%
Teleglow A., Dabrowski Z., Marchewka A., Tabarowski Z., Bilski J., Jaskiewicz J., Gdula-Argasinska J., Glodzik J., Lizak D., Kepinska M.
Folia Biologica
|
2011
|
tom 59
|
nr 3-4
15

Antioxidative activity of pirolidinium salts in the erythrocyte membrane

51%
Kleszczynska H., Sarapuk J., Oswiecimska M., Witek S.
Polish Journal of Environmental Studies
|
2000
|
tom 09
|
nr 6
475-478
The antioxidant activity of two new series of pirolidinium chlorides (PAC-n) and bromides (PAB-n) was studied. The antioxidant functional group was incorporated into the polar part of the compounds. The influence of the compounds on the degree of lipid oxidation in the erythrocyte membrane subjected to UV radiation was studied. It was found that all the salts used protected erythrocyte membranes against oxidation of membrane lipids. Their antioxidant activity increased with alkyl chain length. PAB compounds were stronger oxidation inhibitors than PAC ones. Possible reasons for such behaviour are discussed, taking into account the fluidity changes in erythrocyte membrane caused by the compounds studied. In order to do this, steady-state measurements of fluorescence anisotropy were performed, enabling to calculate the anisotropy coefficient.
16

Effect of cholesterol sulphate on the thermosensitivity and fluidity of human erythrocytes

51%
Przybylska M., Bryszewska M., Epand R. M.
Current Topics in Biophysics
|
1993
|
tom 17
|
nr 1-2
17

Modification of rat liver membranes by aldehydic end-products of lipid peroxidation

51%
Buko V., Artsukevich A., Maltsev A., Shareyko S.
Current Topics in Biophysics
|
1994
|
tom 18
|
nr 2
18

Effects of methyl parathion on model membrane fluidity: Polarization of diphenylhexatriene and intramolecular excimerization of a pyrene derivative

51%
Blasiak J.
Current Topics in Biophysics
|
1993
|
tom 17
|
nr 1-2
19

Effects of phenol, catechol, chloro- and metylphenol on human erythrocyte membrane [in vitro]

45%
Bukowska B., Marczak A., Michalowicz J., Wisniewska K.
Polish Journal of Environmental Studies
|
2009
|
tom 18
|
nr 4
569-577
This study continues our investigations concerning the interaction of phenol, catechol, 2,4-dichlorophenol (2,4-DCP), 2,4,5-trichlorophenol (2,4,5-TCP) and 2,4-dimethylphenol (2,4-DMP) with human erythrocytes. We focus on the effects of these compounds on erythrocyte membrane fluidity, as well as on their impact on membrane proteins. The fluorimetric method and fluorescent probes (ANS, DPH and TMA-DPH) were used to estimate the fluidity of erythrocyte membranes. SDS-gel electrophoresis was carried out to separate the proteins of the cell membrane. Additionally, an analysis of disturbances in size and shape of the erythrocytes by the application of the methods of flow cytometry and microscopic examination was performed. It was observed that phenol derivatives like 2,4-DCP, 2,4,5-TCP, 2,4-DMP and catechol induced changes in membrane fluidity and perturbations in the content of a cell’s membrane proteins. Changes in the level of spectrin, band 3 protein and low molecular weight proteins were also noted. Using three fluorescent probes we observed different changes in membrane fluidity on its different layers, depending on the structure and the concentration of the compound used. The application of flow cytometry and microscopic technique also demonstrated disturbances in the size and shape of erythrocytes. We concluded that chlorophenols induced more severe changes in erythrocyte membrane properties and phenol expressed the lowest toxicity.
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