Preferencje help
Polish version English version Język
Widoczny [Schowaj] Abstrakt
Liczba wyników

Znaleziono wyników: 20

Liczba wyników na stronie
Pierwsza strona wyników Pięć stron wyników wstecz Poprzednia strona wyników Strona / 1 Następna strona wyników Pięć stron wyników wprzód Ostatnia strona wyników

Wyniki wyszukiwania

Wyszukiwano:
w słowach kluczowych:  amphetamine
help Sortuj według:

help Ogranicz wyniki do:
Pierwsza strona wyników Pięć stron wyników wstecz Poprzednia strona wyników Strona / 1 Następna strona wyników Pięć stron wyników wprzód Ostatnia strona wyników
1

Cocaine- and amphetamine-regulated transcript-like immunoreactivity (CART-LI) in intramural ganglia of porcine urinary bladder trigone

100%
Zacharko-Siembida A., Arciszewski M. B.
Medycyna Weterynaryjna
|
2014
|
tom 70
|
nr 10
Although the expression pattern of cocaine- and amphetamine-regulated transcript (CART) has been studied in several porcine tissues, it is notable that no data are available on CART expression in the lower urinary tract. In order to map and determine the neurochemical code of CART-like immunoreactivity in the intramural ganglia of the porcine urinary bladder trigone, cryostat sections were immunohistochemically double-stained for CART and HuC/D, as well as for substance P (SP), calbindin, somatostatin and pituitary adenylate cyclase-activating peptide (PACAP). In the ganglia of the urinary bladder trigone, immunoreactivity to CART was detected both in numerous nerve fibres and in minor subpopulation of HuC/D-positive neuronal cell bodies (2.7 ± 0.8%). Neither CART-immunoreactive (IR) nerve fibres, nor CART-IR ganglionic neurons showed simultaneous expression of somatostatin, calbindin and SP. In a substantial proportion of CART-IR neurons (but not nerve fibres) co-localization with PACAP was found. This data suggest that CART present in nervous structures of the porcine urinary bladder may have a role in the parasympathetic regulation of several urinary bladder functions.
2

Solvent microextraction in routine toxicological analysis of amphetamine and metamphetamine

100%
Janus T., Borowiak K. S., Potocka B., Jarmolowicz Z.
Acta Poloniae Toxicologica
|
2002
|
tom 10
|
nr 2
3

Changes in urine metabolic profiles in patients with chronic intake of amphetamine and opiates revealed using 1H NMR spectroscopy with pattern recognition technique

100%
Janus T., Borowiak K., Rozwadowski Z., Machoy-Mokrzynska A., Suchocka J.
Acta Toxicologica
|
2006
|
tom 14
|
nr 1-2
4

The role of dopamine in the innate attraction towards male pheromones displayed by female mice

84%
Agustin M. C., Martinez-Ricos J., Martinez-Garcia F., Lanuza E.
Acta Neurobiologiae Experimentalis
|
2005
|
tom 65
|
nr 5
5
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
Content available

Inflammation- and axotomy-induced changes in cocaine- and amphetamine-regulated transcript peptide-like immunoreactive (CART-LI) nervous structures in the porcine descending colon

84%
Burlinski P. J.
Polish Journal of Veterinary Sciences
|
2012
|
tom 15
|
nr 3
This study reports on changes in CART-like immunoreactive (CART-LI) nerve structures in the porcine descending colon during chemically driven inflammation and after axotomy. The distribution pattern of CART-LI nerve structures was studied using doublelabeling immunofluorescence technique in the circular muscle layer, myenteric (MP), outer submucous (OSP) and inner submucous plexuses (ISP) and also in the mucosal layer of the porcine descending colon in physiological conditions as well as under pathological factors. In the control animals, CART-LI perikarya have been shown to constitute 5.11% ± 0.64, 4.03% ± 1.17 and 0.05% ± 0.04 in MP, OSP and ISP, respectively. Changes in CART-immunoreactivity depended on the pathological factor and the part of the enteric nervous system (ENS) studied. Numbers of CART-LI perikarya amounted to 2.77% ± 0.64, 2.60% ± 0.36 and 0.26% ± 0.19 during chemically-induced colitis and 3.04% ± 0.88, 2.46% ± 0.8 and 0.43% ± 0.09 after axotomy in MP, OSP and ISP, respectively. Both studied pathological processes also caused an increase in the number of CART-LI nerve fibers in the circular muscle as well as in the mucosal layer.
6

Co-localisation of cocaine- and amphetamine-regulated transcript peptide and vasoactive intestinal polypeptide in the myenteric plexus of the porcine transverse colon

84%
Palus K., Rytel L.
Folia Morphologica
|
2013
|
tom 72
|
nr 4
Cocaine- and amphetamine-regulated transcript peptide (CART) is a substance, which can play the role of neuromediator and/or neuromodulator in nerve structures within the gastrointestinal tract. However knowledge concerning its functions and co-localisation with other neuronal factors is rather scarce. During the present investigation the co-localisation of CART and vasoactive intestinal polypeptide (VIP) in the neurons of meyenteric plexus within the porcine transverse colon was studied using double immunofluorescence technique and semiquantitative arbitrary scale of the frequency of presence CART+/VIP+, CART+/VIP– and CART–/VIP+ neuronal cells. The most often (+++) CART–/VIP+ neurons were encountered, neurons simultaneously immunoreactive to CART and VIP were observed somewhat rarer (++) and only single (+) CART+/VIP– perikarya were visible. The present study reports for the first time on the co-localisation of CART and VIP in myenteric neurons of the porcine transverse colon. (Folia Morphol 2013; 72, 4: 328–332)
7

Emission of 50‑kHz ultrasonic vocalizations in dopamine-denervated rats treated with amphetamine: relevance to neurocircuitries involved in drug-mediated reward

84%
Costa G., Marongiu J., Morelli M., Simola N.
Acta Neurobiologiae Experimentalis
|
2019
|
tom 79
|
nr Suppl.1
Rats emit 50-kHz ultrasonic vocalizations (USVs) in response to pleasurable stimuli, and USVs are increasingly being used to investigate the affective properties of drugs. Dopamine in the shell of the nucleus accumbens is instrumental in the emission of 50-kHz USVs, but little is known about how calling behavior is modulated by other brain regions that receive dopaminergic innervation. To clarify this issue, we evaluated calling behavior stimulated by repeated amphetamine administration in rats subjected to either bilateral or unilateral dopaminergic denervation with 6‑OHDA in the medial prefrontal cortex (mPFC), dorsolateral striatum (DLS), or medial forebrain bundle (MFB). Dopaminergic denervation in the PFC, DLS, or MFB only partially attenuated the development of 50-kHz USVs sensitization during repeated treatment with amphetamine. However, rats bearing a dopaminergic denervation in the mPFC emitted a low number of conditioned USVs upon re-exposure to the amphetamine-paired environment. Sensitization in ultrasonic calling and emission of 50-kHz USVs conditioned to an environment previously paired with drug administration have recently emerged as behavioral correlates of the motivational properties of drugs of abuse. Accordingly, the present results may provide new insight into the neurocircuitries involved in reward and motivation mediated by addictive drugs.
8

Behavioral sensitization to amphetamine induced by a single i.p. dose of oxotremorine in the rat

84%
Gralewicz S.
Acta Neurobiologiae Experimentalis
|
2002
|
tom 62
|
nr 2
9
Content available remote

Effect of ketanserin and amphetamine on nigrostriatal neurotransmission and reactive oxygen species in Parkinsonian rats. In vivo microdialysis study

84%
Nowak P., Szczerbak G., Biedka I., Drosik M., Kostrzewa R. M., Brus R.
Journal of Physiology and Pharmacology
|
2006
|
tom 57
|
nr 4
5-HT2A/2C receptors are one of the most important in controlling basal ganglia outputs. In rodent models of Parkinson's disease (PD) blockade of these receptors increases locomotion and enhances the actions of dopamine (DA) replacement therapy. Moreover, previously we established that 5-HT2A/2C antagonist attenuate DA D1 agonist mediated vacuous chewing movements (VCMs) which are considered as an animal representation of human dyskinesia. These findings implicate 5-HT neuronal phenotypes in basal ganglia pathology, and promote 5-HT2 antagonists as a rational treatment approach for dyskinesia that is prominent in most instances of PD replacement therapy. In the current study we determined whether ketanserin (KET) and/or amphetamine (AMPH) affected dopaminergic neurotranssmision in intact and fully DA-denervated rats. Moreover, we looked into extraneuronal content of HO. of the neostriatum after AMPH and/or KET injection, assessed by HPLC analysis of dihydroxybenzoic acids (2,3- and 2, 5-DHBA) - spin trap products of salicylate. Findings from the present study demonstrated that there are no substantial differences in extraneuronal HO. generation in the neostriatum between control and parkinsonian rats. KET did not affect DA release in the fully DA-denervated rat's neostriatum and also did not enhance HO. production. As 5-HT2A/2C receptor-mediated transmission might prove usefulness not only in addressing motor complications of PD patients (dyskinesia) but also in addressing non-motor problems such depression and/or L-DOPA evoked psychosis, the findings from the current study showed that the use of 5-HT2A/2C receptor antagonists in Parkinson's disease does not impend the neostriatal neuropil to be damaged by these drugs. We concluded that 5-HT2A/2C receptor antagonists may provide an attractive non-dopaminergic target for improving therapies for some basal ganglia disorders.
10

Behavioural responsiveness to amphetamine or scopolamine following repeated exposure to chlorphenvinphos in rats

84%
Gralewicz S., Lutz P., Tomas T.
Acta Neurobiologiae Experimentalis
|
2002
|
tom 62
|
nr 2
11

The contralateral impairment of the orienting ocular-following reflex after lesions of the lateral suprasylvian cortex in cats

84%
Zernicki B., Stasiak M.
Acta Neurobiologiae Experimentalis
|
1994
|
tom 54
|
nr 4
12

The preliminary study of the addictive substances used by high school students

84%
Pach J., Piekoszewski W.
Acta Poloniae Toxicologica
|
2000
|
tom 08
|
nr 2
13
Content available remote

Amphetamine enhances natural killer cytotoxic activity via beta-adrenergic mechanism

67%
Glac W., Borman A., Badtke P., Stojek W., Orlikowska A., Tokarski J.
Journal of Physiology and Pharmacology. Supplement
|
2006
|
tom 57
|
nr 11
125-132
Although addiction to amphetamine (AMPH) is a serious social and medical problem, the data concerning AMPH – immune interactions are still not numerous. To analyze the mechanism of AMPH-induced changes in the function of the immune system, rats were pretreated with ß-adrenergic receptor antagonist propranolol (PROP; 5 mg/kg, i.p.) prior to AMPH (1 mg/kg, i.p.) administration. Natural Killer cells cytotoxicity (NKCC) (51Cr-release assay), the number of LGLs (NK cells) (Timonen method), leukocytes, lymphocytes and monocytes, and plasma corticosterone level (CORT) (RIA) were evaluated in the peripheral blood and spleen. In the peripheral blood increases in NKCC (+331%), as well as in LGL (+33%) and monocyte (+65%) number observed after AMPH were partially inhibited by PROP (respectively by 30%, 19%, and 30%) in contrast to lymphopenia (-19%) and granulocytosis (+65%) which were not affected by ß-blockade. In the spleen AMPH-induced decreases in NKCC (-25%) and in all the leukocyte populations number (approximately -30%) were completely blocked by PROP. Plasma CORT level, highly elevated by AMPH (+337%), was attenuated nearly by 50% under ß-adrenergic blockade. These data indicate that AMPH-induced enhancement of cytotoxic activity of NK cell is related to ß-adrenergic mechanism.
14
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
Content available

Effects of stress pretreatment on the dynamics of blood cholinesterase activity after exposure to an organophosphorus pesticide in the rat

67%
Gralewicz S., Swiercz R., Lutz P., Wiaderna D., Wasowicz W.
Annals of Agricultural and Environmental Medicine
|
2010
|
tom 17
|
nr 1
65-71
15

The alimentary and social instrumental performance in dogs is suppressed by various doses of amphetamine

67%
Fonberg E., Jelen P.
Acta Neurobiologiae Experimentalis
|
1993
|
tom 53
|
nr 1
16

The experience of the department of forensic medicine at the Silesian Medical Academy in Katowice in determination of illegal narcotics quality

67%
Kulikowska J., Sybirska H., Albert M., Soja A.
Acta Poloniae Toxicologica
|
2000
|
tom 08
|
nr 2
17

Chlorpromazine exerts stronger suppressive action on the instrumental responses motivated by social than by alimentary reward

67%
Fonberg E.
Acta Neurobiologiae Experimentalis
|
1992
|
tom 52
|
nr 2
18

Pharmacological and physicochemical properties of collagen breakdown-products

67%
Telejko E., Wrobel K., Wisniewski K., Bankowski E.
Acta Neurobiologiae Experimentalis
|
1992
|
tom 52
|
nr 4
19
Content available remote

7-nitroindazole enhances amphetamine-evoked dopamine release in rat striatum. An in vivo microdialysis and voltammetric study

67%
Nowak P., Brus R., Oswiecimska J., Sokola A., Kostrzewa R. M.
Journal of Physiology and Pharmacology
|
2002
|
tom 53
|
nr 2
The intracellular second messenger nitric oxide (NO) is implicated in a variety of physiological functions, including release and uptake of dopamine (DA). In the described study, in vivo microdialysis and differential pulse voltammetric techniques were used to determine the involvement of NO in release of DA and its metabolites (dihydroxyphenylalanine, DOPAC; homovanillic acid, HVA) in neostriatum of freely moving rats. While the NO donor molsidomine (30.0 mg/kg; MOLS) and neuronal NO synthase- (nNOS-) inhbitor 7-nitroindazole (10.0 mg/kg; 7-NI) had no effect on the basal in vivo microdialysate level of DA, 7-NI specifically enhanced D,L-amphetamine- (1.0 mg/kg i.p.; AMPH) evoked release of DA. Basal or AMPH effects on DOPAC and HVA levels were not influenced by MOLS or 7-NI. Findings indicate that nitrergic systems have an important role in mediating effects of AMPH on dopaminergic systems.
20

Wplyw narkotykow i etanolu na sprzeganie z glutationem w korze mozgowej czlowieka

51%
Gutowicz M., Siwinska-Ziolkowska A., Baranczyk-Kuzma A.
Bromatologia i Chemia Toksykologiczna
|
2004
|
tom 37
|
nr 1
59-64
W pracy przedstawiono aktywność transferazy glutationowej i seleno-niezależnej peroksydazy glutationowej oraz poziom zredukowanego glutationu w różnych częściach kory mózgowej człowieka. Badania prowadzono na tkankach otrzymywanych z autopsji osób zmarłych na skutek zatrucia amfetaminą, kokainą i/lub etanolem.
Pierwsza strona wyników Pięć stron wyników wstecz Poprzednia strona wyników Strona / 1 Następna strona wyników Pięć stron wyników wprzód Ostatnia strona wyników
JavaScript jest wyłączony w Twojej przeglądarce internetowej. Włącz go, a następnie odśwież stronę, aby móc w pełni z niej korzystać.