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  1. 4 Journal of Physiology and Pharmacology

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  1. 3 Tokarz A.

  2. 2 Ciereszko R.

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1
Content available remote

Genistein alleviates testicular ischemia and reperfusion injury-induced spermatogenic damage and oxidative stress by suppressing abnormal testicular matrix metalloproteinase system via the Notch 2/Jagged 1/Hes-1 and caspase-8 pathways

100%
Al-Maghrebi M., Renno W. M.
Journal of Physiology and Pharmacology
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2016
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tom 67
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nr 1
2

The effects of phytoestrogen genistein on steroidogenesis and estrogen receptor expression in porcine granulosa cells of large follicles

100%
Nynca A., Sadowska A., Orlowska K., Jablonska M., Ciereszko R. E.
Folia Biologica
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2015
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tom 63
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nr 2
3

The effect of genistein on two rat prostate cancer cell line s with different metastatic potential

100%
Miekus K., Barczyk K., Madeja Z., Korohoda W.
Cellular and Molecular Biology Letters
|
2002
|
tom 07
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nr Suppl.
4
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
Content available

BonisteinTM (synthetic genistein), a food component in development for a bone health nutraceutical

84%
Ullmann U., Bendik I., Fluhmann B.
Journal of Physiology and Pharmacology. Supplement
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2005
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tom 56
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nr 1
79-95
In the discussion of the risk-benefit relation of the hormone replacement therapy (HRT) for elder women phytochemicals with estrogenic activity received a great deal of attention. Phytoestrogens are naturally occurring compounds with structural similarity to 17b-estradiol. Especially genistein, an isoflavone most abundant in soy, possess a high and selective binding-affinity to the mammalian estrogen receptors. It has been found, that genistein exert in humans both: weak estrogenic and antiestrogenic effects, similar to the SERMs. Consequently, it was concluded, that genistein might provide an alternative to prevent postmenomausal bone-loss and ameliorate menopausal symptoms without side-effects similar to HRT. Pre-clinical experiments and results from clinical pilot studies with pure genistein confirmed its efficacy in these indications. Nevertheless, currently some open issues still exist to recommend its intake thoughtlessly. Bonistein™, pure synthetic genistein developed by DSM Nutritional Products, was tested extensively in appropriate models for bone health. A battery of toxicological studies was conducted to determine safe intake levels. In the early clinical development pharmacokinetic studies were performed in healthy volunteers and in postmenopausal women. Now large-scale studies are in preparation to investigate Bonistein™'s efficacy in postmenopausal bone-loss and climacteric syndrome.
5

Genistein exerts a cell-protective effect via Nrf2/HO-1/ /PI3K signaling in A-beta 25-35-induced Alzheimer’s disease models in vitro

84%
Yi S., Chen S., Xiang J., Tan J., Huang K., Zhang H., Wang Y., Wu H.
Folia Histochemica et Cytobiologica
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2021
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tom 59
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nr 1
6

The effect of genistein on some hormones and metabolic parameters in the immature, female rats

84%
Nogowski L., Nowicka E., Szkudelski T., Szkudelska K.
Journal of Animal and Feed Sciences
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2007
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tom 16
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nr 2
274-282
7

Dynamics and distribution of dry matter and total nitrogen in yellow lupine (Lupinus luteus L.) plants

84%
Prusinski J.
Electronic Journal of Polish Agricultural Universities. Series Agronomy
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2014
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tom 17
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nr 2
8
Content available remote

Genistein and daidzein affect in vitro steroidogenesis but not gene expression of steroidogenic enzymes in adrenals of pigs

84%
Kaminska B., Czerwinska J., Wojciechowicz B., Nynca A., Ciereszko R.
Journal of Physiology and Pharmacology
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2014
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tom 65
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nr 1
9
Content available remote

In vitro effects of genistein and daidzein on the activity of adrenocortical steroidogenic enzymes in mature female pigs

84%
Kaminska B., Ciereszko R., Kiezun M., Dusza L.
Journal of Physiology and Pharmacology
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2013
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tom 64
|
nr 1
10

The influence of genistein on insulin, leptin, thyroid hormones and metabolic parameters in mature rats

84%
Nowicka-Stanczyk E., Szkudelski T., Szkudelska K., Nogowski L.
Journal of Animal and Feed Sciences
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2012
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tom 21
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nr 1
Genistein is a phytoestrogen and is found in many plants consumed by humans and animals. This isoflavone was found to exert metabolic effects, especially on lipid and carbohydrate metabolism. The aim of this experiment was to determine whether genistein at a dose of 1 and 5 mg/kg body weight administered intragastrically to male and female adult rats changes insulin, leptin, thyroid hormone, and metabolic parameters. The results suggest that genistein has only a slight influence on metabolism. A substantial reduction of triglyceride stores was observed in the skeletal muscles. This effect was sex-dependent and occurred only in females. Moreover, it was demonstrated that genistein at the higher dose decreased blood insulin and leptin levels.
11
Content available remote

Genistein affects parathyroid gland and NaPi 2a cotransporter in an animal model of the andropause

84%
Pantelic J., Ajdzanovic V., Medigovic I., Mojic M., Trifunovic S., Milosevic V., Filipovic B.
Journal of Physiology and Pharmacology
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2013
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tom 64
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nr 3
12

Synthetic derivatives of genistein, their properties and possible applications

84%
Rusin A., Krawczyk Z., Grynkiewicz G., Gogler A., Zawisza-Puchalka J., Szeja W.
Acta Biochimica Polonica
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2010
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tom 57
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nr 1
23-34
 Genistein, the principal isoflavone constituent of soybean, attracts much attention as a natural molecule with significant affinity towards targets of potential medicinal interest, but also as a food supplement or prospective chemopreventive agent. Since its physicochemical properties are considered suboptimal for drug development, much effort has been invested in designing its analogs and conjugates in hope to obtain compounds with improved efficacy and selectivity. The aim of this article is to summarize current knowledge about the properties of synthetic genistein derivatives and to discuss possible clinical application of selected novel compounds. Some basic information concerning chemical reactivity of genistein, relevant to the synthesis of its derivatives, is also presented.
13

Effects of genistein on insulin pathway-related genes in mouse differentiated myoblast C2C12 cell line: evidence for two independent modes of action

84%
Lewicki S., Lewicka A., Kalicki B., Sobolewska-Ruta A., Debski B., Zdanowski R., Syrylo T., Kloc M., Kubiak J. Z.
Folia Histochemica et Cytobiologica
|
2018
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tom 56
|
nr 3
14

Genistein inhibits the contact-stimulated migration of prostate cancer cells

84%
Miekus K., Madeja Z.
Cellular and Molecular Biology Letters
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2007
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tom 12
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nr 3
The results of several epidemiological studies have suggested that a soybean-based diet is associated with a lower risk of prostate cancer. We investigated the effect of the soy isoflavone genistein on the proliferation and contact-stimulated migration of rat prostatic carcinoma MAT-LyLu and AT-2 cell lines. Genistein almost completely inhibited the growth of both MAT-LyLu and AT-2 cells in the concentration range from 25 to 100 μM, but the addition of 1 μM genistein to the medium significantly stimulated the proliferation of both cell lines. Additionally, at concentrations above 25 μM, genistein showed a potent cytotoxic effect. However, the central finding of this study is that at physiologically relevant concentrations (1 μM and 10 μM), genistein inhibits the motility of prostate cancer cells stimulated by homo-and heterotypic contacts. These results show that at physiological concentrations, genistein exerts an inhibitory effect on the migration of prostate cancer cells and suggest that it may be one of the factors responsible for the anti-metastatic activity of plant isoflavonoids.
15

Effect of intracerebroventricular infusion of genistein on prolactin and LH secretion in ovariectomized ewes during short days

84%
Romanowicz K., Misztal T.
Journal of Animal and Feed Sciences
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2005
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tom 14
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nr 2
16

A comparative study of the effects of genistein, estradiol and raloxifene on the murine skeletal system

67%
Sliwinski L., Folwarczna J., Nowinska B., Cegiela U., Pytlik M., Kaczmarczyk-Sedlak I., Trzeciak H., Trzeciak H. I.
Acta Biochimica Polonica
|
2009
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tom 56
|
nr 2
261-270
Genistein, a major phytoestrogen of soy, is considered a potential drug for prevention and treatment of postmenopausal osteoporosis. The aim of the present study was to compare the effects of genistein, estradiol and raloxifene on the skeletal system in vivo and in vitro. Genistein (5 mg/kg), estradiol (0.1 mg/kg) or raloxifene hydrochloride (5 mg/kg) were administered daily by a stomach tube to mature ovariectomized Wistar rats for 4 weeks. Bone mass, mineral and calcium content, macrometric parameters and mechanical properties were examined. Also the effects of genistein, estradiol and raloxifene (10-9-10-7 M) on the formation of osteoclasts from neonatal mouse bone marrow cells and the activity of osteoblasts isolated from neonatal mouse calvariae were compared. In vivo, estrogen deficiency resulted in the impairment of bone mineralization and bone mechanical properties. Raloxifene but not estradiol or genistein improved bone mineralization. Estradiol fully normalized the bone mechanical properties, whereas genistein augmented the deleterious effect of estrogen-deficiency on bone strength. In vitro, genistein, estradiol and raloxifene inhibited osteoclast formation from mouse bone marrow cells, decreasing the ratio of RANKL mRNA to osteoprotegerin mRNA expression in osteoblasts. Genistein, but not estradiol or raloxifene, decreased the ratio of alkaline phosphatase mRNA to ectonucleotide pyrophosphatase phosphodiesterase 1 mRNA expression in osteoblasts. This difference may explain the lack of genistein effect on bone mineralization observed in ovariectomized rats in the in vivo study. Concluding, our experiments demonstrated profound differences between the activities of genistein, estradiol and raloxifene towards the osseous tissue in experimental conditions.
17

Food components targeting the epigenome

67%
Gerhauser C.
Polish Journal of Food and Nutrition Sciences
|
2011
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tom 61
|
nr Suppl.1
18

Putative biological mechanisms of efficiency of substrate reduction therapies for mucopolysaccharidoses

67%
Banecka-Majkutewicz Z., Jakobkiewicz-Banecka J., Gabig-Ciminska M., Wegrzyn A., Wegrzyn G.
Archivum Immunologiae et Therapiae Experimentalis
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2012
|
tom 60
|
nr 6
19
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
Content available

Rola genisteiny w procesie enzymatycznej hydrolizy albuminy w obecnosci azotanow [III] i [V]

67%
Tokarz A., Pokorska-Lis G., Popiel E.
Roczniki Państwowego Zakładu Higieny
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2008
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tom 59
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nr 3
319-326
Polifenole i azotany są nieodłącznym składnikiem naszej diety. Szkodliwość związków azotanowych jest znana i badana od dawna. Korzystne właściwości polifenoli są wciąż poznawane i wzbudzają ogromne zainteresowanie. Celem pracy było zbadanie interakcji zachodzących pomiędzy azotanami (III) і (V) a genisteiną w układach odtwarzających proces enzymatycznego trawienia białka (albuminy). Zastosowano model in vitro pozwalający na przeprowadzenie enzymatycznej hydrolizy kwaśno-zasadowej albuminy w obecności azotanów, polifenoli i witaminy C w różnych układach stężeń. W dializacie oznaczano zawartość azotanów metodą spektrofotometryczną z odczynnikami Griess 'a. Stwierdzono hamujący wpływ genisteiny na obecność NO2- w kompartmencie zewnętrznym, przy czym kierunek oddziaływania zależał od dawki polifenolu (dla azotanów (III) od 11,21% do 7,27%, dla azotanów (V) od 95,64% do 79,64% dializy). Genisteina wprowadzana do układu badawczego w zbyt dużych stężeniach - powyżej 2,4 mg/układ - nie tylko nie wywoływała wzmocnienia przewidywanego efektu, ale wręcz powodowała jego cofnięcie. Wykazano także synergizm w oddziaływaniu genisteiny z resweratrolem oraz witaminą C.
20
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
Content available

Effects of endogenous signals and F. oxysporum on the mechanism regulating genistein synthesis and accumulation in yellow lupine and their impact on plant cell cytoskeleton

67%
Morkunas I., Formela M., Marczak L., Samardakiewicz S., Kasprowicz A., Wojtaszek P.
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
|
2013
|
tom 94
|
nr 3
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