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Effect of quercetin on bone mineral status and markers of bone turnover in retinoic acid-induced osteoporosis

100%

Orsolic N., Jelec Z., Nemrava J., Balta V., Gregorovic G., Jelec D.

Polish Journal of Food and Nutrition Sciences

2018

tom 68

nr 2

Retinoic acid-induced osteoporosis (RBM) is one of the most common causes of secondary osteoporosis. This study tested the anti-osteoporetic effect of quercetin in RBM-induced bone loss model (RBM). After 14-day supplementation of 13cRA to induce RBM, rats were administered with quercetin (100 mg/kg) or alendronate (40 mg/kg). We analysed changes in body and uterine weight of animals, femoral geometric characteristics, calcium and phosphorus content, bone weight index, bone hystology, bone mineral density (BMD), markers of bone turnover, lipid peroxidation, glutathione levels and SOD, CAT activity of liver, kidney spleen, and ovary as well as biochemical and haematological variables. In comparison to the control RBM rats, the treatment with quercetin increased bone weight index, BMD, osteocalcin level, femoral geometric characteristics, calcium and phosphorus content in the 13cRA-induced bone loss model. Histological results showed its protective action through promotion of bone formation. According to the results, quercetin could be an effective substitution for alendronate in 13cRA-induced osteoporosis. Good therapeutic potential of quercetin on rat skeletal system is based partly on its antioxidant capacity and estrogenic activity.

Effects of four-week intake of blackthorn flower extract on mice tissue antioxidant status and phenolic content

84%

Balta V., Dikic D., Crnic I., Odeh D., Orsolic N., Kmetic I., Murati T., Dragovic Uzelac V., Landeka Jurcevic I.

Polish Journal of Food and Nutrition Sciences

2020

tom 70

nr 4

The study examined the antioxidative physiological effects of phenolics from an ethanol-water extract of blackthorn flowers orally administrated to C57/BL6 mice for 28 days in daily doses of 25 mg of total phenolics/kg body weight. Contents of phenolics in the intestine, liver, and kidneys collected after 1, 7, 14, 21, and 28 days of extract administration were analyzed by UPLC-MS/MS method. In the same tissues, the antioxidative properties were determined as ferric reducing antioxidant power (FRAP), ABTS•+ scavenging activity, content of reduced glutathione (GSH), and activity of superoxide dismutase (SOD) and catalase (CAT). The lipid peroxidation in tissues was also evaluated by thiobarbituric acid reactive substances (TBARS) assay. The exposed mice (compared to the control ones) had a lower content of TBARS in all tissues mostly on the third/fourth week of daily consumption. SOD activity and GSH content increased on the 28th day in tissues. CAT activity was higher only in the liver after one week of consumption but remained unchanged in other organs throughout the experiment. Phenolic profiles were different in individual tissues. The most prominent increases compared to the control were determined for contents of 3-O-feruloylquinic acid, 4-O-p-coumaroylqiunic acid, kaempferol pentoside, and quercetin rhamnoside in the intestine; for ferulic acid and quercetin 3-O-rutinoside in the liver; and for quercetin 3-O-rutinoside, ferulic acid, and 4-O-p-coumaroylquinic acid in the kidneys. The screened phenolics with different distribution in tissues could be responsible for slight differences in the recorded antioxidative effects.

Ograniczanie wyników

2 Polish Journal of Food and Nutrition Sciences

2 Balta V.

2 Orsolic N.

1 Crnic I.

1 Dikic D.

1 Dragovic Uzelac V.

1 Gregorovic G.

1 Jelec D.

1 Jelec Z.

1 Kmetic I.

1 Landeka Jurcevic I.

1 Murati T.

1 Nemrava J.

1 Odeh D.

1 2020

1 2018

Wyniki wyszukiwania

Effect of quercetin on bone mineral status and markers of bone turnover in retinoic acid-induced osteoporosis

Effects of four-week intake of blackthorn flower extract on mice tissue antioxidant status and phenolic content