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1
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
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Evaluation of anti-gout activity of some plant food extracts

100%
Mohamed D. A., Al-Okbi S. Y.
Polish Journal of Food and Nutrition Sciences
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2008
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tom 58
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nr 3
The anti-gout activity of methanol and petroleum ether extracts of celery leaves, celery seeds, rosemary, cinnamon and turmeric as functional food components was studied in potassium oxonate treated rats (250 mg/kg body weight, intra-peritoneal). Blood samples were collected from all rats after an overnight fast and after 3 and 6 h from oxonate injection for determination of erythrocyte sedimentation rate (ESR), plasma uric acid, nitric oxide (NO) and malondialdehyde (MDA). Urine samples were collected for 6 h after injection for the determination of uric acid. Assessment of total phenolic contents, fatty acids and unsaponifiable matter (UNSAP) in the plants under study was carried out. Results showed that oxonate treatment produced a significant increase in all studied parameters compared to the healthy rats. Oral administration of different extracts (500 mg/kg body weight) showed a significant reduction in plasma and urine uric acid levels, petroleum ether extract of celery seeds was the most promising. The majority of administered extracts showed significant reduction in inflammatory (ESR and NO) and oxidative stress (MDA) markers with variable degrees. GLC investigation of plants UNSAP revealed the presence of different phytosterols. GLC analysis of the fatty acids methyl ester showed that celery seeds and leaves contained the highest contents of oleic and linoleic acid, respectively. Linolenic acid was only present in celery seeds and leaves. All the studied plants were rich in phenolics; rosemary was superior in this respect. In conclusion, the studied plant extracts showed significantly variable anti-gout activity associated with both antioxidant and antiinflammatory effects, which may be due to the presence of phenolic compounds, unsaturated fatty acids, long chain fatty acids and phytosterols.
2
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
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Evaluation of potential health benefits of two novel special foods in liver cirrhotic patients

81%
Al-Okbi S. Y., Shalaby S. I., Mohamed D. A., Hamed T. E.
Polish Journal of Food and Nutrition Sciences
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2010
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tom 60
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nr 1
Two therapeutic diets have been formulated (A & B) and prepared in bakery form for patients with liver cirrhosis. The formulation was based on the presence of protein of high Fisher ratio and fat rich in medium chain triglycerides. Both formulas contained edible sources of antioxidants. Honey was added as a sweetener. Proximate analysis of Formula B and its contents of amino acids and fatty acids were carried out. Formula A was analysed in previous research for the same above mentioned composition. The two formulas were sensory evaluated by liver cirrhotic patients. Potential benefits of both formulas in addition of nutritional advice were evaluated in liver cirrhotic patients. Biochemical parameters reflecting liver function (plasma AST, ALT, ALP, total bilirubin, direct bilirubin and ammonia), oxidative stress (plasma NO and MDA) and nutritional status (plasma total protein, albumin, globulin and A/G ratio) were studied before and after two months of dietary intervention. The nutritional status of patients was evaluated through anthropometric measurements, food intake and selected biochemical parameters. Proximate analysis results showed that formula B contain 17.6% protein and 7.5% fat. Amino acids analysis of the same formula showed that its Fisher ratio was 2.49. GC analysis of fatty acids revealed that medium chain fatty acids constitute 38.6% of total fatty acids. The results of sensory evaluation showed that overall score of formula A was significantly higher than that of formula B. Nutritional status determined through triceps skin fold at the start of the clinical study showed 38% of cases were normal, 8% were severely malnourished and 54% over normal. Analysis of mean dietary intake of patients in the beginning of the study revealed that all liver cirrhotic patients were hypo-caloric. All estimated nutrients were lower than RDA except for protein. Mean dietary intake of patient after two months of the study revealed that all patients increased their caloric intake however they were still hypo-caloric. Comparing biochemical parameters of patients before and after dietary intervention of either formulas and nutritional advice revealed that all parameters reflecting liver dysfunction were non significantly improved. However AST activity significantly decreased on supplementation of diet A. A significant increase in plasma albumin and total protein was noticed in patients after both dietary interventions which may reflect some improvements in liver synthetic function and nutritional status. Ammonia was only significantly decreased in patients given formula A. Nitric oxide and MDA were significantly reduced in both dietary interventions with different degrees. In conclusion, both dietary interventions in addition of dietary advice in the present study have beneficial effects towards liver cirrhotic patients concerning reduction of oxidative stress and inflammation. Formula A was superior in reducing plasma AST activity and ammonia level.
3

Impact of feeding bread enriched with flaxseed on plasma profile of hyperlipidemic rats - a short report

81%
Mohamed D. A., El-Hariri D. M., Al-Okbi S. Y.
Polish Journal of Food and Nutrition Sciences
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2005
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tom 14/55
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nr 4
4
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
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Rice bran oil and pumpkin seed oil alleviate oxidative injury and fatty liver in rats fed high fructose diet

81%
Al-Okbi S. Y., Mohamed D. A., Hamed T. E., Esmail R. S. H.
Polish Journal of Food and Nutrition Sciences
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2014
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tom 64
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nr 2
5
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
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Potential health benefits of bread supplemented with defatted flaxseeds under dietary regimen in normal and type 2 diabetic subjects

81%
Mohamed D. A., Al-Okbi S. Y., El-Hariri D. M., Mousa I. I.
Polish Journal of Food and Nutrition Sciences
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2012
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tom 62
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nr 2
Flaxseed is a rich source of dietary fi bers and lignans. Uncontrolled diabetes may induce complication represented by dyslipidemia, high oxidative stress and kidney dysfunction. In the present research the benefi cial effect of two months consumption of bread supplemented with defatted fl axseeds (DFB) together with dietary regimen was evaluated in normal and type 2 diabetic patients. Protective effect towards diabetic complications was studied through evaluation of plasma lipid profi le, lipid peroxidation, liver and kidney function. The nutritional status of normal and diabetic patients was evaluated through assessing body mass index and nutrients’ intake. Results showed reduction of body mass index in both normal and diabetic patients after nutritional intervention. Analysis of mean dietary intake of normal and diabetic patients in the beginning of the study revealed that all subjects were hyper- -caloric that reduced to be 79% and 84% from RDA, respectively after treatment. After two months of supplementation with DFB, diabetic patients showed signifi cant reduction of plasma glucose. Both diabetic patients and normal subjects showed signifi cant improvement in plasma lipid profi le and signifi cant reduction of lipid peroxidation. Consumption of DFB in addition of dietary regimen may be helpful in preventing diabetes and its complications.
6

Role of micronutrient mixture in acute and persistent diarrhea in infants and its impact on nutritional status

81%
Soliman S. M., Helwa A. H., Al-Shafei M. M., Al-Okbi S. Y.
Polish Journal of Food and Nutrition Sciences
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2003
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tom 12/53
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nr 3
The present research dealt with comparing the effect of zinc-vitamin A-micronutrient mixture (ZAMM) administration on the nutritional status of infants with acute and persistent diarrhea. In addition, its effect on the management of both types of diarrhea was studied. Zinc and vitamin A were given as 8 mg and 751 µg retinol equivalent respectively per day. The results showed that administration of ZAMM produced an increase in body weight and a significant increase in haemoglobin concentration in acute and persistent diarrheal cases with a significant increase in mean corpuscular volume in persistent diarrhea cases. Plasma zinc and vitamin A levels showed a significant increase in acute diarrheal infants after supplementation of ZAMM. Certain parameters, reflecting management of diarrhea such as appetite, stool frequency and duration of diarrhea, have been improved after ZAMM supplementation. Conclusion: ZAMM administration improved both nutritional status and diarrheal state in infants with either acute or persistent diarrhea, however its effect was more promissing in acute cases.
7
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
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Plant food extracts as a source of bioactive compounds for prevention of cisplatin-induced kidney dysfunction in rats

71%
Al-Okbi S. Y., Mohamed D. A., Hamed T. E., Esmail R. S., Donya S. M.
Polish Journal of Food and Nutrition Sciences
|
2014
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tom 64
|
nr 1
The present study investigated the protective effect of extracts prepared from grape, coriander, roselle and fennel in a rat model of kidney dysfunction induced by intraperitoneal cisplatin. A mixture of ethanol and petroleum ether extracts was prepared from a given plant. Six groups of rats were analyzed; control healthy, cisplatin group and 4 test groups where rats were given a daily oral dose of each extract mixture before cisplatin injection. Different biochemical and cytogenetic parameters and kidney histopathology were determined. Total phenolic contents, fatty acids and unsaponifiable matter (UNSAP) were assessed in the extracts. Results showed roselle ethanol extract to have the highest phenolic content (15.584 g GAE/100 g extract). Fatty acid analysis revealed the presence of linoleic and linolenic acid in all studied plants. Coriander oil showed the highest content of unsaturated fatty acids (85%). GLC investigation of the UNSAP showed the presence of campesterol in all the studied plants. Grape oil contained the highest content of phytosterol (15.9%). Cisplatin treatment induced significant increase in plasma urea, creatinine and malondialdehyde along with significant reduction in plasma albumin, total protein, catalase activity and total antioxidant level as well as reduction in creatinine clearance compared to normal control. Histopathological examination proved the induction of kidney dysfunction by cisplatin. Chromosomal aberration and sperm-shape abnormalities were noticed after cisplatin treatment. Administration of extract mixtures produced improvements in biochemical, histopathological and cytogenetic parameters. Extracts mixture under study offered protection from cisplatin induced kidney dysfunction via antioxidant and possibly anti-inflammatory actions.
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