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1

Badania neurobehawioralne w farmakologii

100%
Piechal A., Widy-Tyszkiewicz E.
Prace i Materiały Zootechniczne
|
2008
|
tom 66
2

Interakcje lekow roslinnych stosowanych w chorobach ukladu oddechowego

81%
Blecharz-Klin K., Piechal A., Pyrzanowska J., Widy-Tyszkiewicz E.
Herba Polonica
|
2005
|
tom 51
|
nr 3-4
87-105
Leki roślinne są często stosowane w terapii schorzeń układu oddechowego. Gdy są przyj­mowanie jednocześnie z lekami konwencjonalnymi, zwiększa to ryzyko wystąpienia inter­akcji ze składnikami farmakologicznie czynnymi roślin leczniczych. Na podstawie zarówno wyników badań klinicznych, jak i doświadczeń przedklinicznych omówiono najczęściej używane preparaty pochodzenia roślinnego. Przedstawiono najczęstsze interakcje wpływające w znacznym stopniu na przebieg terapii schorzeń układu oddechowego.
3

Interakcje lekow roslinnych stosowanych w chorobach ukladu pokarmowego

81%
Pyrzanowska J., Piechal A., Blecharz-Klin K., Widy-Tyszkiewicz E.
Herba Polonica
|
2006
|
tom 52
|
nr 1-2
75-96
4
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Dihydroergotamine (DHE) – Is there a place for its use?

81%
Piechal A., Blecharz-Klin K., Mirowska-Guzel D.
Journal of Pre-Clinical and Clinical Research
|
2018
|
tom 12
|
nr 4
5

Pharmacological and biochemical effects of Ginkgo biloba extract of learning, memory consolidation and motor activity in old rats

71%
Blecharz-Klin K., Piechal A., Joniec I., Pyrzanowska J., Widy-Tyszkiewicz E.
Acta Neurobiologiae Experimentalis
|
2009
|
tom 69
|
nr 2
217-231
Effect of administration of the standardized extract of Ginkgo biloba leaves (EGb 761) on learning, memory and exploratory behavior was estimated in water maze and hole-board tests. Rats (18-month old) received for three months EGb 761 at doses: 50, 100 and 150 mg/kg b.w. per day. After completion of the behavioral experiment, concentrations of neurotransmitters were estimated in selected brain regions. ANOVA demonstrated significant differences in the content of monoamines and metabolites between the treatment groups compared to the control. The increased level of 5-hydroxytryptamine (5-HT) in the hippocampus and 5-HIAA (5-HT metabolite) in the prefrontal cortex correlated positively with the retention of spatial memory. Positive correlation between platform crossings in SE during the probe trial and neurotransmitter turnover suggest improvement of spatial memory. Long-term administration of Ginkgo biloba extract can improve spatial memory and motivation with significant changes in the content and metabolism of monoamines in several brain regions.
6

Different immune response of brain areas and the inolvement of inflammatory cytokines (IL-1, IL-6, TNFalfa) in spatial learning and memory deficits after MPTP injury in mice

71%
Zaremba M., Kurkowska-Jastrzebska I., Cudna A., Piechal A., Czlonkowski A.
Acta Neurobiologiae Experimentalis
|
2011
|
tom 71
|
nr S
Parkinson’s disease (PD) is a neurodegenerative disorders causing not only motor dysfunction, but also cognitive disturbance. The pattern of cognitive deficits in PD often includes: executive impairments, episodic memory deficits and visuospatial dysfunctions. It also became evident that inflammatory processes play an important role in the pathophysiology of PD. Neurodegeneration intense brain immune activation and “cytokine storm” which might induce hyper-excitability of neuronal circuits and might reduce neuronal plasticity and cause impairments in learning and memory abilities. The role of cytokines in regulation of inflammatory responses in different brain regions during PD is unclear. It still remains to be fully understood as to how cytokines participate in the molecular and cellular mechanisms of deficits in learning, memory and cognition in PD. Loss of dopaminergic neurons in acute 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) models is associated with massive and prolonged glial response and increased production and release of inflammatory mediators. To assess the inflammatory response following MPTP intoxication, we measured the IL-6, IL-1β and TNFα gene expression by real-time quantitative RT-PCR following the Morris water maze behavioral test that was provided at 7 days, 3 and 6 months from the intoxication. Our results indicate that neuroinflammatory activity in MPTP model was not restricted to the nigrostriatal system but also involved hippocampal and cortical areas, regions there are essential for cognitive functions such as working and long - term memory, not only in mice. To evaluate spatial learning and memory abilities of mice the mean latency of reaching the platform, the swimming distance, the time spent in the goal quadrant and crossing parameters were estimated. We found that these parameters correlated with level of mRNA expression of cytokines in hippocampus and cortex.
7

Wpływ długotrwałego podawania rutyny na pamięć przestrzenną i neuroprzekaźnictwo u szczurów

71%
Pyrzanowska J., Blecharz-Klin K., Piechal A., Joniec-Maciejak I., Widy-Tyszkiewicz E.
Annals of Warsaw University of Life Sciences - SGGW. Animal Science
|
2011
|
tom 48
8

Mice lines divergently selected for body mass show significant differences in spatial learning

71%
Blecharz-Klin K., Piechal A., Pyrzanowska J., Wirth-Dzieciolowska E., Widy-Tyszkiewicz E.
Polish Journal of Natural Sciences
|
2015
|
tom 30
|
nr 1
The present study was aimed to investigate the influence of multigenerational selection in the direction of low or high body weight on spatial learning and memory in mice. Light and heavy lines of rodents were selected from an outbred stock constructed from inbred strains; A/St, BN/a, BALB/c and C57BL/6J. Male mice selected at weaning for the low (L, n=13) or high (H, n=16) body weight for 94 generations have been evaluated for behavioral performance and cognition in the modified Morris water maze task. The unselected control line (Con, n=15) was run in parallel. Presented results lead to the conclusion that selection of mice for high and low body weight over 94 generations resulted in a significant differentiation in learning abilities. Our findings suggest improvement of learning of the hidden platform position in heavy line of mice.
9
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Whey administration modulates spatial memory in a water maze

61%
Blecharz-Klin K., Piechal A., Joniec I., Zobel A., Pyrzanowska J., Widy-Tyszkiewicz E.
Journal of Pre-Clinical and Clinical Research
|
2011
|
tom 05
|
nr 1
10
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Influence of long-term administration of Curcuma longa extract on explorative activity in aged rats

61%
Pyrzanowska J., Piechal A., Blecharz-Klin K., Gutowicz M., Baranczyk-Kuzma A., Widy-Tyszkiewicz
Journal of Pre-Clinical and Clinical Research
|
2010
|
tom 04
|
nr 2
11

Hippocampal and cortical neuroinflammation in experimental autoimmune encephalomyelitis is not accompanied by deficits of spatial memory in a late phase of the disease

61%
Kurkowska-Jastrzebska I., Swiatkiewicz M., Zaremba M., Piechal A., Cudna A., Oderfeld-Nowak B.
Acta Neurobiologiae Experimentalis
|
2011
|
tom 71
|
nr S
Cognitive dysfunctions are common features of multiple sclerosis. The exact mechanism of their appearance is unknown. The disconnection of some parts of the cortex reflecting an axonal loss, neuronal damage and alterations in synaptic transmission, have been postulated. In the present study, an autoimmune encephalomyelitis (EAE), a common model of multiple sclerosis, was induced passively by lymphocytes transfer, to evoke a one-phase disease in Lewis rats. The inflammatory reactions and neural injury in the hippocampus and frontal cortex were investigated. We found a decrease of the number of CA1 and CA4 pyramidal neurons by about 25% on 30 dpi and by about 50% in CA1 region on 90 dpi. This was accompanied by prolonged astroglial activation and by a rise of the pro-inflammatory cytokine mRNA expression (IL-1β, IL-6 and TNFα). A significant rise of NGF and BDNF was also found. In the frontal cortex, neural degeneration was not so evident. A slight astrocyte activation and a strong increase of expression of IL 6 on 30 dpi and IL1β and TNFα on 90 dpi was seen. Learning and memory abilities (Morris water-maze tests) were also evaluated 30 and 90 dpi. The mean latency of reaching the platform, the swimming distance, the time spent in the goal quadrant and crossing parameters were estimated. The reaction of animals suffering from EAE was not different from that of the control group, in any of the tasks except 20% higher chance for reaching the platform on 30 dpi. We demonstrated therefore the lack of correlation between strong neuroinflammation in the hippocampus and cortex and the deficits in memory and learning ability at a late phase of the disease. However, the severity of motor impairment during earlier stages of the disease made difficult identification of any early cognitive deficits. The possibility exists that early deficits could be later compensated due to simultaneously occurring compensatory processes involving activity of neurotrophic factors.
12

Influence of dopaminergic system injury on working memory abilities

61%
Zaremba M. M., Kurkowska-Jastrzebska I., Joniec I., Piechal A., Blecharz-Klin K., Balkowiec-Iskra E. Z., Czlonkowski A.
Acta Neurobiologiae Experimentalis
|
2007
|
tom 67
|
nr 3
13
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Administration of Greek Royal Jelly produces fast response in neurotransmission of aged Wistar male rats

61%
Pyrzanowska J., Piechal A., Blecharz-Klin K., Joniec-Maciejak I., Graikou K., Chinou J., Widy-Tyszkiewicz E.
Journal of Pre-Clinical and Clinical Research
|
2015
|
tom 09
|
nr 2
Introduction. Royal Jelly (RJ) is a popular bee-derived product used widely in European and Asian traditional medicine. RJ has some pharmacological activities to support health and longevity as well as prevent ageing. Objectives. To evaluate whether a short-term 6-day Royal Jelly administration is able to induce behavioural and neurochemical effects in aged rats. Materials and method. RJ (previously chemically characterized by GC-FID and GC–MS) was given to 18-month-old male Wistar rats (100 and 500mg of powder/kg b.w./day) in subcutaneous injection for 6 days. Spatial memory was assessed in a water maze. Afterwards, the level of neurotransmitters, their metabolites and turnover in the selected brain regions were estimated by HPLC. Results. Short-term RJ administration did not change spatial memory in aged rats in the water maze, although it was sufficiently active to modify most of all the serotonergic and dopaminergic transmission in the prefrontal cortex and hippocampus. Conclusion. The obtained results indicate that Royal Jelly is able to affect very quickly the neurotransmission in the brain structures responsible for cognitive performance; however, short-term administration is not sufficient to exert behavioural consequences.
14
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Dihydroergotamine affects spatial behavior and neurotransmission in the central nervous system of Wistar rats

61%
Piechal A., Blecharz-Klin K., Joniec-Maciejak I., Pyrzanowska J., Krzysztoforska K., Mirowska-Guzel D., Widy-Tyszkiewicz E.
Annals of Agricultural and Environmental Medicine
|
2021
|
tom 28
|
nr 3
15

Autoimmune encephalomyelitis is accompanied by the injury of hippocampal neurons

51%
Kurkowska-Jastrzebska L., Zaremba M., Cudna A., Piechal A., Swiatkiewicz M., Zaremba M., Czlonkowska A., Oderfeld-Nowak B.
Acta Neurobiologiae Experimentalis
|
2009
|
tom 69
|
nr 3
Multiple sclerosis (MS) is associated with cognitive defi cits, developing independently from motor disorders. These defi cits may be associated with brain neuronal damage. In this study, using the experimental model for MS – autoimmune encephalomyelitis (EAE), we investigated whether EAE will result in the damage of hippocampal neurons and selective defi cits in learning and memory, and whether there may be a correlation between the two phenomena. Lewis rats 3 months old were injected with 4 millions of anti-MBP CD4+ T cells to evoke EAE. Animals suffered from tail and hind limb paresis and recovered after 10 dpi. T cells infi ltrated spinal cord and many brain regions including hippocampus. We demonstrated the decrease of pyramidal neurons in CA4 region by about 20%, as evaluated by stereological measurements, at 21 dpi. This was preceded by prolonged glial activation as well as by a rise of the pro-infl ammatory cytokine mRNA expression (IL-1β, IL-6 and TNF α). However, no differences in the water maze test were detected between the EAE and control groups, on 21 dpi and on 90 dpi. In conclusion, anti-MBP CD4+ T cells are capable of injuring hippocampal pyramidal neurons during EAE, probably, through the secretion of pro-infl ammatory cytokines. However, in the studied conditions, hippocampal neurodegeneration caused by T cells did not result in memory disturbances. Supported by the grant no N401- 1293-33 of the Ministry of Scientifi c Research and Information Technology in Poland.
16

The molecular and behavioral changes in the long-term observations in mice model of Parkinson's disease

51%
Zaremba M., Joniec L., Piechal A., Pyrzanowska J., Kurkowska-Jastrzebska L., Ciesielska A., Czlonkowska A., Czlonkowski A.
Acta Neurobiologiae Experimentalis
|
2009
|
tom 69
|
nr 3
The pathogenesis of non-motor symptoms in Parkinson’s disease (PD) is complex and not fully understood, but is believed to be related to the widespread nature of dopaminergic dysfunction involving structures beyond the substantia nigra. Therefore we’ve also focused in our experiments on specifi c brain regions (e.g. hippocampus and prefrontal cortex) critically involved in spatial learning and memory processes. One year old C57/BL male mice received 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrindine (MPTP) 40 mg/kg, and control group received 0.9 % NaCl. To evaluate spatial learning and memory abilities, the Morris water maze (WM) behavioral test was provided after 6 months from the intoxication. The brain concentration of monoamines: dopamine (DA), noradrenaline (NA), 5 – hydroxytryptamine (5-HT) and amino acid: glutamate (Glu) were determined by using high – performance liquid chromatography (HPLC). Statistical signifi cances differences in monoamines levels between groups were noticed in hippocampus (NA, DA content) and prefrontal cortex (NA content). We didn’t notice signifi cant differences in the WM test parameters between MPTP and the control animals. Correlation between the results of the behavioral testing in the probe trial and the level of monoamines were calculated. Swim distance to reach the hidden platform was negatively correlated with NA level in the hippocampus (rp=−0.62, P<0.05). There is need for a further investigation to confi rm the role for NA in spatial memories.
17

The role of neurogenesis in learning:studies of cyclin D2 knock-out mice

51%
Filipkowski N. P., Kiryk A., Knapska E., Jaholkowski P., Kowalczyk A., Piechal A., Blecharz-Klin K., Widy-Tyszkiewicz E., Kaczmarek L.
Acta Neurobiologiae Experimentalis
|
2005
|
tom 65
|
nr 3
18

New hippocampal neurons are not obligatory for memory formation:mice with no adult brain neurogenesis show learning

42%
Jaholkowski P., Kiryk A., Jedynak P., Ben Abdallah N., Knapska E., Kowalczyk A., Piechal A., Blacharz-Klin K., Widy-Tyszkiewicz E., Wilczynski G., Lipp H., Kaczmarek L., Filipkowski R.
Acta Neurobiologiae Experimentalis
|
2009
|
tom 69
|
nr 3
New neurons are produced in the brains of adult animals, including humans, throughout the lifespan. Since one of the site of adult brain neurogenesis is the hippocampal formation, a brain structure involved in learning and memory, new neurons were expected to be involved in these phenomena. However, the very evidence supporting this hypothesis remains limited, inconsistent and in most cases indirect. Also, the experiments in which adult neurogenesis is blocked use irradiation and drugs known for their side effects. We used a novel approach, cyclin D2 knock-out mice (D2 KO mice), specifi cally lacking adult brain neurogenesis (which was verifi ed using DCX and NeuN staining) to verify its importance in learning and memory. D2 KO mice and their wild type siblings were tested in several behavioral paradigms including those in which the role of adult neurogenesis has been postulated. D2 KO mice showed no impairment in sensorimotor tests with only sensory impairment in an olfaction-dependent task. However, D2 KO mice showed proper procedural learning as well as learning in context (including remote memory), cue and trace fear-conditioning, Morris water maze, novel object recognition test, and in a multifunctional behavioral system – Intellicages. Our results suggest that adult brain neurogenesis is not obligatory in learning, including the kinds of learning where the role of adult neurogenesis has previously been strongly suggested. Support – MNiSW grant no N303 051 31/1624.
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