Wyniki wyszukiwania

1

Grelina – hormon żarłoczności?

100%

Dembinski A., Warzecha Z.

Kosmos

|

2010

|

tom 59

|

nr 3-4

2

Wpływ popularyzacji wiedzy o wartości odżywczej warzyw na sprzedaż surówek i sałatek w restauracji zależnie od jej lokalizacji

81%

Czarnocinska J., Dembinski A., Gawecki J.

Żywienie Człowieka i Metabolizm. Suplement

|

2005

|

tom 32

|

nr 1 cz.1

Badania zrealizowano w dwóch restauracjach poznańskich z sieci „ Tivoli", w trzech etapach, z których każdy trwał cztery tygodnie. W każdym etapie rejestrowano codziennie ilość sprzedawanych surówek i sałatek z baru sałatkowego. W etapie drugim i trzecim zastosowano dwa sposoby promocji warzyw. Sprzedaż surówek i sałatek z baru sałatkowego istotnie wzrosła po zastosowaniu promocji warzyw, przy czym była ona uzależniona od sposobu promocji, nie zależała zaś od czasu jej trwania. Lokalizacja restauracji miała istotne znaczenie dla sprzedaży surówek i sałatek z baru sałatkowego, wykazując jednocześnie znamienny związek ze skutecznością prowadzonej promocji warzyw. W śródmiejskiej restauracji sprzedaż surówek i sałatek była istotnie niższa aniżeli w restauracji osiedlowej, ale efekt promocji warzyw był w niej bardziej widoczny. Uzyskane wyniki pozwalają sądzić, że poprzez niewielkie działania popularyzatorskie można zmieniać zachowania żywieniowe ludzi w kierunku zgodnym z zasadami racjonalnego żywienia.

3

Peptidyl hormones of endocrine cells origin in the gut - their discovery and physiological relevance

81%

Ceranowicz P., Warzecha Z., Dembinski A.

Journal of Physiology and Pharmacology

|

2015

|

tom 66

|

nr 1

4

Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik

Helicobacter pylori and gastric adaptation to repeated aspirin administration in humans

81%

Konturek J. W., Dembinski A., Konturek S. J., Domschke W.

Journal of Physiology and Pharmacology

|

1997

|

tom 48

|

nr 3

5

Helicobacter pylori and gastric adaptation to repeated aspirin administration in humans

81%

Konturek J. W., Dembinski A., Konturek S. J., Domschke W.

Journal of Physiology and Pharmacology. Supplement

|

1997

|

tom 48

|

nr 1

6

The role of capsaicin - sensitive sensory neurons and nitric oxide in regulation of gastric mucosal growth

81%

Dembinski A., Warzecha Z., Ceranowicz P., Konturek S. J.

Journal of Physiology and Pharmacology

|

1995

|

tom 46

|

nr 3

7

Absorption of amino acids from the small bowel and their activity in releasing of cholecystokinin

71%

Radecki T., Thor P., Dembinski A., Mitis M., Konturek S. J.

Acta Physiologica Polonica

|

1977

|

tom 28

|

nr 5

8

The effects of antagonists of receptors for gastrin, cholecystokinin and bombesin on growth of gastroduodenal mucosa and pancreas

71%

Dembinski A., Warzecha Z., Konturek S. J., Zhi Cai R., Schally A. V.

Journal of Physiology and Pharmacology

|

1991

|

tom 42

|

nr 2

The effects of gastrin, cholecystojdnin (CCK) and bombesin on the DNA synthesis, as a biochemical indicator of trophic action in the gastroduodenal mucosa and the pancreas have been examined in rats fasted for 48 h and in rats refed for 16 h with or without administration of specific receptor antagonists for bombesin, gastrin and CCK. Bombesin and gastrin administered three times daily for 48 h in fasted rats significantly increased the rate of DNA synthesis as measured by the incorporation of [³H] thymidine into DNA in each tissue tested. CCK significantly increased DNA synthesis in the duodenal mucosa and pancreatic tissue, but not in the gastric mucosa. The stimulation of DNA synthesis induced by bombesin in the gastroduodenal mucosa and pancreas was abolished by bombesin/GRP receptor antagonist, RC-3095. RC-3095 did not affect DNA synthesis stimulated by gastrin and CCK in these tissues. L-365,260, a receptor antagonist for gastrin suppressed the DNA synthesis induced by gastrin but not by CCK or bombesin in the gastrointestinal mucosa and pancreas. L-364, 718 a specific antagonist for CCK receptors was effective only against CCK stimulated duodenal mucosa and pancreatic growth. Refeeding of 48 h fasting rats strongly enhanced the DNA synthesis in all tissues tested, and this effect was significantly reduced in the gastroduodenal mucosa by blocking only gastrin receptors (with L-365, 260) and that in the duodenal mucosa and the pancreas by antagonizing of CCK receptors (with L-364, 718). Antagonism of bombesin receptors (with RC-3095) did not significantly affect the stimulation of DNA synthesis induced by refeeding in all tissues tested. This study indicates that the stimulation of DNA synthesis can be achieved by exogenous gastrin, CCK and bombesin acting through separate receptor but that only gastrin and CCK play the major role in the postprandial stimulation of the growth of gastroduodenal mucosa and pancreatic tissue.

9

Influence of sensory nerves and CGRP on the course of experimental pancreatitis and pancreatic regeneration

71%

Dembinski A., Warzecha Z., Ceranowicz P., Stachura J., Konturek S. J.

Journal of Physiology and Pharmacology. Supplement

|

2001

|

tom 52

|

nr 2

10

Brain-gut axis in ischemic preconditioning of gastro-duodeno-pancreatic cluster

71%

Konturek S. J., Brzozowski T., Pajdo R., Dembinski A., Jaworek J.

Journal of Physiology and Pharmacology. Supplement

|

2001

|

tom 52

|

nr 2

11

Ghrelin accelerates the healing of oral ulcers in non-sialoadenectomized and in sialoadenectomized rats

61%

Warzecha Z., Kownacki P., Ceranowicz P., Dembinski M., Cieszkowski J., Dembinski A.

Journal of Physiology and Pharmacology

|

2013

|

tom 64

|

nr 5

12

The effect of exogenous apelin on the secretion of pancreatic juice in anaesthetized rats

61%

Kapica M., Jankowska A., Antushevich H., Pietrzak P., Bierla J. B., Dembinski A., Zabielski R.

Journal of Physiology and Pharmacology

|

2012

|

tom 63

|

nr 1

13

Involvement of cyclooxygenase-1 and cyclooxygenase-2 activity in the therapeutic effect of ghrelin in the course of ethanol-induced gastric ulcers in rats

61%

Warzecha Z., Ceranowicz P., Dembinski M., Cieszkowski J., Ginter G., Ptak-Belowska A., Dembinski A.

Journal of Physiology and Pharmacology

|

2014

|

tom 65

|

nr 1

14

The effect of antagonist of receptors for gastrin, cholecystokinin and bombesin on growth of gastroduodenal mucosa and pancreas

61%

Dembinski A., Warzecha Z., Konturek S. J., Banas M., Cai R.-Z., Schally A. V.

Journal of Physiology and Pharmacology

|

1991

|

tom 42

|

nr 3

The effects of gastrin, cholecystokinin (CCK) and bombesin on the DNA synthesis, as a biochemical indicator of trophic action in the gastroduodenal mucosa and the pancreas, have been examined in rats fasted for 48 h and in rats refed for 16 h with or without administration of specific receptor antagonists for bombesin, gastrin and CCK. Bombesin and gastrin administered three times daily for 48 h in fasted rats significantly increased the rate of DNA synthesis as measured by the incorporation of [³H] thymidine into DNA in each tissue tested. CCK significantly increased DNA synthesis in the duodenal mucosa and pancreatic tissue, but not in the gastric mucosa. The stimulation of DNA synthesis induced by bombesin in the gastroduodenal mucosa and pancreas was abolished by bombesin/GRP receptor antagonist, RC-3095. RC-3095 did not affect DNA synthesis stimulated by gastrin and CCK in these tissues. L-365,260, a receptor antagonist for gastrin suppressed the DNA synthesis induced by gastrin but not by CCK or bombesin in the gastrointestinal mucosa and pancreas. L-364,718, a specific antagonist for CCK receptors was effective only against CCK stimulated duodenal mucosa and pancreatic growth. Refeeding of 48 h fasting rats strongly enhanced the DNA synthesis in all tissues tested, and this effect was significantly reduced in the gastroduodenal mucosa by blocking only gastrin receptors (with L-365, 260) and that in the duodenal mucosa and the pancreas by antagonizing of CCK receptors (with L-364, 718). Antagonism of bombesin receptors (with RC-3095) did not significantly affect the stimulation of DNA synthesis induced by refeeding in all tissues tested. This study indicates that the stimulation of DNA synthesis can be achieved by exogenous gastrin, CCK and bombesin acting through separate receptors, but that only gastrin and CCK play the major role in the postprandial stimulation of the growth of gastroduodenal mucosa and pancreatic tissue.

15

Role of sensory nerves in gastroprotective effect of anandamide in rats

61%

Warzecha Z., Dembinski A., Ceranowicz P., Dembinski M., Cieszkowski J., Kownacki P., Konturek P. C.

Journal of Physiology and Pharmacology

|

2011

|

tom 62

|

nr 2

Previous studies have shown that stimulation of cannabinoid 1 (CB1) receptor protects the gastric mucosa against stress-induced lesion. Aim of the present study was to examine the influence of anandamide on lipid peroxidation and antioxidant defense system in gastric mucosa and the role of sensory nerves in gastroprotective effects of cannabinoids. Studies were performed on rats with intact or ablated sensory nerves (by neurotoxic doses of capsaicin). Gastric lesions were induced by water immersion and restrain stress (WRS). Anandamide was administered at the dose of 0.3, 1.5 or 3.0 µmol/kg, 30 min before exposure to WRS. CB1 receptor antagonist, AM251 (4.0 µmol/kg) was administered 40 min before WRS. WRS induced gastric lesions associated with the decrease in gastric blood flow, mucosal DNA synthesis and mucosal activity of superoxide dismutase (SOD). Serum level of interleukin-1ß (IL-1ß) and mucosal level of malondialdehyde (MDA) and 4-hydroxynonenal (4-HNE) were increased. Administration of anandamide reduced the ulcers area, generation of MDA+4-HNE and serum level of IL-1ß, and this effect was associated with the reduction in the WRS-induced decrease in gastric mucosal blood flow, mucosal DNA synthesis and SOD activity. Ablation of sensory nerves increased the area of ulcers, serum level of IL-1ß and mucosal content of MDA+4-HNE, whereas mucosal DNA synthesis, SOD activity and blood flow were additionally decreased. In rats with ablation of sensory nerves, administration of anandamide at the high doses (1.5 and 3.0 µmol/kg) partly reduced deleterious effect of WRS on gastric mucosa, but this effect was weaker than in animals with intact sensory nerves. Low dose of anandamide (0.3 µmol/kg) was ineffective in the protection of gastric mucosa against the WRS-induced lesions in rats with ablation of sensory nerves. In rats with intact sensory nerves and exposed to WRS, administration of AM251 exhibited deleterious effect. In rats with ablation of sensory nerves and exposed to WRS, AM251 failed to affect mucosal injury in the stomach. We conclude that anandamide reduces the mucosal oxidative stress and exhibits gastroprotective effect against WRS-induced ulcers. These effects are partly mediated by sensory nerves.

16

Stimulation of sensory nerves and CGRP administration attenuates development pancreatitis evoked by ischemia-reperfusion

61%

Warzecha Z., Dembinski A., Ceranowicz P., Sendur R., Pawlik W. W., Konturek S. J.

Journal of Physiology and Pharmacology. Supplement

|

2001

|

tom 52

|

nr 2

17

Role of afferent nerves and sensory peptides in the mediation of hepatic artery buffer response

61%

Biernat J., Pawlik W. W., Sendur R., Dembinski A., Brzozowski T., Konturek S. J.

Journal of Physiology and Pharmacology

|

2005

|

tom 56

|

nr 1

Intrahepatic arteries are richly innervated by both adrenergic and sensory vanilloid-sensitive (capsaicin-sensitive) fibers. Stimulation of capsaicin sensitive fibers has been shown to dilate the intrahepatic vessels by both releasing sensory neuropeptides and by modulating the adrenergic tone. However the participation of capsaicin-sensitive fibers in the mediation of the hepatic artery buffer response (HABR) has not been investigated yet. To explore the involvement of sensory innervation and sensory neuropeptides in the HABR, the experiments were performed on capsaicin-denervated Wistar rats. In addition, we used selective CGRP and tachykinin receptor antagonists to test the participation of CGRP, substance P and NK-A in HABR in the rat. In anesthetized rats the hepatic artery blood flow (HABF), microcirculatory hepatic blood flow (HBF) and portal blood flow (PBF) were determined. The HABR was induced by partial occlusion of the portal vein and maintaining the PBF at 10% of its control preocclusive value. In the control HABR the hepatic artery blood flow increased by 89% (p< 0.005) whilst the HBF at the same time decreased by 32% (p< 0.005) in comparison to preocclusive HABF and HBF values. In sensory-denervated rats the resting HBF and PBF were increased by 23% (p< 0.05) and 34% (p< 0.05), respectively in comparison to the control HBF and PBF values. In this group the induction of the HABR increased the hepatic artery blood flow by only 55% (p< 0.05), whilst the HBF was reduced by 45% (p< 0.05). Pretreatment with CGRP 8-37 (CGRP receptor antagonist) and NK-1 but not NK-2 nor NK-3 receptor antagonists significantly reduced the HABF by 43% (p< 0.05) and 25 % (p< 0.05) as compared to the HABF value in the control HABR group. These findings support the hypothesis that the hepatic artery buffer response induced by reduction of the portal inflow to the liver by 90% is partially mediated by activation of capsaicin-sensitive sensory fibers in the liver, probably due to local tissue ischemia and hypoxia. The observed vasodilation in the vascular bed of the hepatic artery is due to stimulation of CGRP and NK-1 receptors.

18

Effect of sensory nerves and CGRP on the development of caerulein-induced pancreatitis and pancreatic recovery

61%

Warzecha Z., Dembinski A., Ceranowicz P., Stachura J., Tomaszewska R., Konturek S. J.

Journal of Physiology and Pharmacology

|

2001

|

tom 52

|

nr 4,1

The function of primary sensory neurons is to receive and transmit information from external environment and these neurons are able to release neuromediators from the activated peripheral endings. The aim of this study was to determine the influence of sensory nerves and administration of their mediator — calcitonin gene related peptide (CGRP) on the course of acute pancreatitis (AP). Ablation of sensory nerves was performed by neurotoxic dose of capsaicin (100 mg/kg). Single or repeated episodes of AP were induced by caerulein infusion (10 µg/kg/h for 5 h). Five repeated AP were performed once a week. Capsaicin at the dose which stimulates sensory nerves (0.5 mg/kg/dose) or CGRP (10 µg/kg/dose) was administrated before and during or after single induction of AP, as well as, after each induction of repeated AP. Rats were killed at the time 0, 3 or 9 h after single induction of AP or two weeks after last induction of repeated AP. Ablation of sensory nerves aggravated pancreatic damage in caerulein-induced AP. Treatment with stimulatory doses of capsaicin or CGRP before and during single induction of AP attenuated the pancreatic damage in morphological examination. This effect was also manifested by partial reversion of AP evoked drop in DNA synthesis and pancreatic blood flow (PBF). Administration of CGRP after single AP induction aggravated histologically manifested pancreatic damage. The further decrease in PBF and DNA synthesis was also observed. Animals with five episodes of AP showed almost full pancreatic recovery two weeks after last induction of AP concerning all parameters tested. In stimulatory doses of capsaicin treated rats, we observed the decrease in pancreatic amylase and fecal chymotrypsin activity, as well as, the drop in DNA synthesis. Similar but less pronounced effects were observed after treatment with CGRP. We conclude that effect of sensory nerves and CGRP on AP is two-phase and time dependent. Stimulation of sensory nerves or the administration of CGRP during development of AP exhibits protective effects against pancreatic damage induced by caerulein overstimulation. After induction of AP, persistent activity of sensory nerves and presence of CGRP aggravate pancreatic damage and lead to functional insufficiency typical for chronic pancreatitis.

19

Expression of transforming growth factor-beta1 and epidermal growth factor in caerulein-induced pancreatitis in rat

61%

Konturek P. C., Dembinski A., Warzecha Z., Ceranowicz P., Konturek S. J., Stachura J., Hahn E. G.

Journal of Physiology and Pharmacology

|

1997

|

tom 48

|

nr 1

20

Role of sensory nerves in pancreatic secretion and caerulein - induced pancreatitis

61%

Warzecha Z., Dembinski A., Jaworek J., Ceranowicz P., Szlachcic A., Walocha J., Konturek S. J.

Journal of Physiology and Pharmacology

|

1997

|

tom 48

|

nr 1

Ograniczanie wyników

Grelina – hormon żarłoczności?

Wpływ popularyzacji wiedzy o wartości odżywczej warzyw na sprzedaż surówek i sałatek w restauracji zależnie od jej lokalizacji

Peptidyl hormones of endocrine cells origin in the gut - their discovery and physiological relevance

Helicobacter pylori and gastric adaptation to repeated aspirin administration in humans

Helicobacter pylori and gastric adaptation to repeated aspirin administration in humans

The role of capsaicin - sensitive sensory neurons and nitric oxide in regulation of gastric mucosal growth

Absorption of amino acids from the small bowel and their activity in releasing of cholecystokinin

The effects of antagonists of receptors for gastrin, cholecystokinin and bombesin on growth of gastroduodenal mucosa and pancreas

Influence of sensory nerves and CGRP on the course of experimental pancreatitis and pancreatic regeneration

Brain-gut axis in ischemic preconditioning of gastro-duodeno-pancreatic cluster

Ghrelin accelerates the healing of oral ulcers in non-sialoadenectomized and in sialoadenectomized rats

The effect of exogenous apelin on the secretion of pancreatic juice in anaesthetized rats

Involvement of cyclooxygenase-1 and cyclooxygenase-2 activity in the therapeutic effect of ghrelin in the course of ethanol-induced gastric ulcers in rats

The effect of antagonist of receptors for gastrin, cholecystokinin and bombesin on growth of gastroduodenal mucosa and pancreas

Role of sensory nerves in gastroprotective effect of anandamide in rats

Stimulation of sensory nerves and CGRP administration attenuates development pancreatitis evoked by ischemia-reperfusion

Role of afferent nerves and sensory peptides in the mediation of hepatic artery buffer response

Effect of sensory nerves and CGRP on the development of caerulein-induced pancreatitis and pancreatic recovery

Expression of transforming growth factor-beta1 and epidermal growth factor in caerulein-induced pancreatitis in rat

Role of sensory nerves in pancreatic secretion and caerulein - induced pancreatitis