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1

Nowe oblicza czynników indukowanych przez hipoksję – HIF-1 i HIF-2 a stres oksydacyjny

100%
Stachurska A., Florczyk U., Jozkowicz A., Dulak J., Loboda A.
Postępy Biochemii
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2010
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tom 56
|
nr 2
2

HIF-1 induction attenuates inter-leukine-8-synthesis in human endothelial cells

100%
Loboda A., Rudnicka D., Jazwa A., Jozkowicz A., Dulak J.
Acta Biochimica Polonica
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2006
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tom 53
|
nr Supplement 1
3

Rola czynnika transkrypcyjnego Nrf2 w odpowiedzi komórkowej na stres oksydacyjny

100%
Florczyk U., Loboda A., Stachurska A., Jozkowicz A., Dulak J.
Postępy Biochemii
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2010
|
tom 56
|
nr 2
4

Nrf2 influences satellite cells and muscle regeneration but does not aggravate the progression of Duchenne muscular dystrophy

72%
Bronisz-Budzynska I., Kozakowska M., Chwalenia K., Podkalicka P., Mucha O., Loboda A., Jozkowicz A., Dulak J.
Acta Biochimica Polonica
|
2018
|
tom 65
|
nr S2
5

Expression of cellular retinoic acid-binding protein I and II (CRABP I and II) in embryonic mouse hearts treated with retinoic acid

72%
Stachurska E., Loboda A., Niderla-Bielinska J., Szperl M., Juszynski M., Jozkowicz A., Dulak J., Ratajska A.
Acta Biochimica Polonica
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2011
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tom 58
|
nr 1
Cellular retinoic acid binding proteins are considered to be involved in retinoic acid (RA) signaling pathways. Our aim was to compare the expression and localization of cellular retinoic acid binding proteins I and II (CRABP I and II) in embryonic mouse hearts during normal development and after a single teratogenic dose of RA. Techniques such as real-time PCR, RT-PCR, Western blots and immunostaining were employed to examine hearts from embryos at 9-17 dpc. RA treatment at 8.5dpc affects production of CRABP I and II in the heart in the 48-h period. Changes in expression of mRNA for retinaldehyde dehydrogenase II (Raldh2), Crabp1 and Crabp2 genes also occur within the same time window (i.e. 10-11dpc) after RA treatment. In the embryonic control heart these proteins are localized in groups of cells within the outflow tract (OT), and the atrioventricular endocardial cushions. A gradient of labeling is observed with CRABP II but not for CRABP I along the myocardium of the looped heart at 11 dpc; this gradient is abolished in hearts treated with RA, whereas an increase of RALDH2 staining has been observed at 10 dpc in RA-treated hearts. Some populations of endocardial endothelial cells were intensively stained with anti-CRABP II whereas CRABP I was negative in these structures. These results suggest that CRABP I and II are independently regulated during heart development, playing different roles in RA signaling, essential for early remodeling of the heart tube and alignment of the great arteries to their respective ventricles.
6

Kidney injury by cyclosporine A is aggravated in heme oxygenase-1 deficient mice and involves regulation of microRNAs

72%
Loboda A., Mucha O., Podkalicka P., Sobczak M., Miksza-Cybulska A., Kaczara P., Jozkowicz A., Dulak J.
Acta Biochimica Polonica
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2018
|
tom 65
|
nr 4
7

Regulacja ekspresji genow w wektorach plazmidowych: system zalezny od doksycykliny i regulowany przez niedotlenienie

72%
Golda S., Kucharzewska P., Cisowski J., Florczyk U., Zagorska A., Jazwa A., Loboda A., Jozkowicz A., Dulak J.
Biotechnologia
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2007
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nr 3
82-97
8
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Effect of plant extracts on angiogenic activities of endothelial cells and keratinocytes

72%
Loboda A., Cisowski J., Zarebski A., Jazwa A., Rivera Nunez D., Kypriotakis Z., Heinrich M., Dulak J.
Journal of Physiology and Pharmacology. Supplement
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2005
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tom 56
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nr 1
125-137
Numerous bioactive chemical compounds of plant origin may influence the angiogenic activity of various cell types and may thus affect the formation of blood vessels. Here we present the angiogenic effects of extracts of edible plants collected in Crete, Southern Italy and Southern Spain. Extracts have been applied to cultured human microvascular endothelial cells (HMEC-1), human umbilical vein endothelial cells (HUVEC) and human keratinocytes (HaCaT). About half out of 96 extracts exerted an inhibitory effect on HMEC-1 proliferation. Additionally, we have noted the inhibitory effects of extracts on HUVEC differentiation on a Matrigel layer. None of the extracts showed a stimulatory activity. The extract of Thymus piperella exerted moderate inhibitory effect on cobalt-chloride induced VEGF synthesis, however, CoCl2-induced activation of hypoxia responsive element of VEGF promoter was significantly attenuated only by extract of Origanum heracleoticum. Our study indicates that extracts of local food plants, of potential value as nutraceuticals, contain chemical compounds which may inhibit angiogenesis. Demonstration of their real influence on human health requires, however, extensive animal studies and controlled clinical investigations.
9

Pharmacological versus genetic inhibition of heme oxygenase-1 - the comparison of metalloporphyrins, shRNA and CRISPR/Cas9 system

72%
Mucha O., Podkalicka P., Czarnek M., Biela A., Mieczkowski M., Kochamakova-Trojanowska N., Stepniewski J., Jozkowicz A., Dulak J., Loboda A.
Acta Biochimica Polonica
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2018
|
tom 65
|
nr 2
10

Targeting inflammation for treatment of Duchenne muscular dystrophy

72%
Kozakowska M., Mucha O., Podkalicka P., Pietraszek-Gremplewicz K., Bronisz-Budzynska I., Jozkowicz A., Loboda A., Dulak J.
Acta Biochimica Polonica
|
2018
|
tom 65
|
nr S2
11

HO-1 as a possible drug target

59%
Podkalicka P., Mucha O., Barwacz S., Andrysiak K., Biela A., Kruczek S., Ryszawy D., Mikulski M., Sitarz K., Golezowski M., Bialas A., Rzymski T., Brzozka K., Jozkowicz A., Dulak J., Loboda A.
Acta Biochimica Polonica
|
2018
|
tom 65
|
nr S2
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