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2011 | 71 | 1 |

Tytuł artykułu

Novel, highly antinociceptive hybrid compound in acute pain

Warianty tytułu

Języki publikacji

EN

Abstrakty

EN
The clinical treatment of various types of pain relies upon opioid analgesic, however most of them produce, in addition to the analgesic effect, several side effects such as development of dependence and addiction as well as sedation, dysphoria, and constipation. One of the solutions to these problems are chimeric compounds in which opioid pharmacophore is hybridized with other type of synergically active antinociceptor. Neurotensin-induced antinociception is not mediated through the opioid system. Therefore, hybridizing neurotensin with opioid element may result in a potent synergic antinociceptor. The opioid-neurotensin hybride analogue PK20, in which opioid and neurotensin pharmacophores partially overlapped, expresses high antinociceptive tail-flick effects after central as well as peripheral applications. The antinociceptive effects likely are result of synergistic/additive interaction of hybridized opioid and neurotensin pharmacophores.

Słowa kluczowe

Wydawca

-

Rocznik

Tom

71

Numer

1

Opis fizyczny

p.163

Twórcy

  • Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland
autor
  • Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland
  • Department of Organic Chemistry, Vrije Universiteit Brussel, Brussels, Belgium
autor
  • Faculty of Pharmaceutical Sciences, Kobe Gakuin University, Kobe, Japan
autor
  • Department of Organic Chemistry, Vrije Universiteit Brussel, Brussels, Belgium
  • Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland

Bibliografia

Typ dokumentu

Bibliografia

Identyfikatory

Identyfikator YADDA

bwmeta1.element.agro-1220efa9-6900-4170-afd6-7d9e90232d9b
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