From mild cognitive impairment to dementia

• Autorzy: Gabryelewicz T.
• Języki publikacji: EN

Abstrakty

EN

The significance of cognitive decline in the elderly has been widely discussed in the literature. In particular, complaints of memory impairment are common in the elderly and were found in 80% of various community samples. Different approaches have been proposed to describe this decline and its relationship with the development of dementia. Unfortunately, the difficulty in disentangling “normal”, purely age-associated cognitive changes from changes related to early degenerative or vascular diseases has resulted in a lack of agreement on terminology and specific diagnostic criteria. Although there are a number of different definitions of mild cognitive deficits, the general concept is of a subjective memory impairment, and/or another domain in the context of cognitive impairment relative to age-matched controls and yet showing no loss of function and no dementia. Mild cognitive impairment (MCI) is a heterogeneous group with a variety of clinical outcomes. Most of the subjects will convert to dementia, but some MCI may never progress to any significant extent or even improve. The field of MCI research is currently focusing on identifying the risk factors of disease progression for the purpose of early therapeutic intervention, which may in turn delay or even prevent the onset of dementia. Individuals with a MCI are at an increased risk of developing dementia ranging from 3% to 15% per year. The prevalence of MCI varies from 15 to 30% of the population. Most of the studies demonstrate the age-dependent increase of MCI prevalence.

• Wydawca: -
• Czasopismo: Acta Neurobiologiae Experimentalis
• Rocznik: 2011
• Tom: 71
• Numer: 1
• Opis fizyczny: p.144

Twórcy

autor

Gabryelewicz T.

• Mossakowski Medical Research Centre, Department of Neurodegenerative Disorders, Polish Academy of Sciences, Warsaw, Poland