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1

Telomerase as a therapeutic target

100%
Huminiecki L.
Acta Biochimica Polonica
|
1996
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tom 43
|
nr 3
Ribonucleoprotein telomerase is an enzyme that elongates telomeric DNA. In cells without detectable telomerase activity telomeres shorten with every cell generation and reaching critical length is a signal for cell death. Normal human somatic cells express undetectable, or low (bone marrow and peripheral leukocytes), telomerase activity. Reactivation of telomerase (immortalization) is probably necessary during development of a fully malignant cancer. Consequently, telomerase was proposed to be a therapeutic target for the cancer therapy. Potential results (including side-effects) of telomerase inhibition are being considered. After all, telomerase inhibition can be useful not only in the therapy, but also in cancer biology research, elucidating ageing and immortalization phenomena.
2

Effect of antioestrogens on proliferation, differentiation and telomerase activity of pig granulosa cells in vitro

84%
Chronowska E., Tomanek M., Kott T.
Journal of Animal and Feed Sciences
|
2010
|
tom 19
|
nr 4
3

Age dynamics of telomere length of Baikal gastropods is sex-specific and multidirectional

84%
Maximova N., Koroleva A., Sitnikova T., Khanaev I., Bukin Y., Kirilchik S.
Folia Biologica
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2017
|
tom 65
|
nr 4
4

Androgen receptor inhibitor stimulates telomerase activity of pig granulosa cells in vitro

84%
Chronowska E., Kott T.
Animal Science Papers and Reports
|
2011
|
tom 29
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nr 4
The aim of the study was to investigate the effect of testosterone (T) and dihydrotestosterone (DHT) applied alone or in combination with antiandrogen (flutamide) on proliferation, progesterone secretion and telomerase activity (TA) of pig granulosa cells (GC) derived from small (1-3 mm; SFGC) and large (5-7 mm; LF-GC) ovarian follicles. Cells were treated with investigated factors for 48 h. 5α-DHT stimulated (P<0.05-0.01) proliferation of SF and LF granulosa cells. Flutamide applied individually and in a combination with testosterone and DHT stimulated (P<0.05-0.01) proliferation of pig GC from small and large antral follicles. Flutamide had no effect on progesterone synthesis in small as well as in large follicle GC. Antiandrogen applied individually and in a combination with testosterone and DHT enhanced (P<0.05-0.01) telomerase actitvity in SF- and LF-GC. The results of the study suggest the involvement of androgen receptor in telomerase activity regulation in pig GC and a link between telomerase and the proliferation status of GC.
5
Content available remote

Effect of long-term culture on the biological and morphological characteristics of human adipose tissue-derived stem cells

67%
Danisovic L., Oravcova L., Krajciova L., Varchulova Novakova Z., Bohac M., Varga I., Vojtassak J.
Journal of Physiology and Pharmacology
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2017
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tom 68
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nr 1
6
Content available remote

Successful ageing of nonagenarians is related to the sensitivity of NK cells to activation

67%
Kaszubowska L., Dettlaff-Pokora A., Hak L., Szarynska M., Ryba M., Mysliwska J., Mysliwski A.
Journal of Physiology and Pharmacology. Supplement
|
2008
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tom 59
|
nr 9
187-199
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