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  1. 5 Bromatologia i Chemia Toksykologiczna

  2. 4 Journal of Physiology and Pharmacology

  3. 2 Acta Biochimica Polonica

  4. 2 Herba Polonica

  5. 2 Reproductive Biology

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  1. 3 Kaminska B.

  2. 3 Nynca A.

  3. 3 Slomczynska M.

  4. 2 Biernat J.

  5. 2 Bloniarz J.

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  1. 1 2020

  2. 2 2017

  3. 3 2015

  4. 1 2014

  5. 1 2013

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1

Phytoestrogen action in Leydig cells of Bilgoraj ganders (Anser anser)

100%
Opalka M., Kaminska B., Puchajda-Skowronska H., Dusza L.
Reproductive Biology
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2006
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tom 06
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nr Suppl.2
2

The effects of phytoestrogen genistein on steroidogenesis and estrogen receptor expression in porcine granulosa cells of large follicles

100%
Nynca A., Sadowska A., Orlowska K., Jablonska M., Ciereszko R. E.
Folia Biologica
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2015
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tom 63
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nr 2
3

The effect of phytoestrogens on the reproductive tract

100%
Slomczynska M.
Polish Journal of Veterinary Sciences
|
2004
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tom 07
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nr 3
Environmental estrogens may be derived from plants (phytoestrogens), pharmaceuticals or synthetic compounds. They exert estrogenic and/or potentially antiestrogenic effects on farm animals, wildlife and humans. Exposure to these compounds results in some abnormalities in the reproductive tract, changes in the estrous cycle, and possibly protection against the development of hormone- dependent cancer. The data obtained from animal studies suggest that the timing of exposure to phytoestrogens is important, and neonatal exposure causes the most pronounced effects.
4

Influence of isoflavones on secretion of oestradiol-17beta by bovine granulosa cells in vitro

84%
Ras M., Kaminski T., Janowski T., Zdunczyk S.
Bulletin of the Veterinary Institute in Puławy
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2010
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tom 54
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nr 3
Granulosa cells were isolated from large (≥8 mm) follicles and incubated for 24 h without or with LH (100 ng/mL), daidzein, genistein or equol in doses of 0.5, 5, 10, and 50 µg/mL each or combination (3:13:39) of these isoflavones at a dose 50 µg/ml. The concentration of oestradiol-17ß in incubation media was measured by RIA. All the isoflavones at used doses decreased significantly basal and LH-stimulated secretion of oestradiol-17ß by granulosa cells in a dose dependent manner. The combination of these isoflavones also inhibited significantly oestradiol-17ß secretion by the cells. These data suggested that decreased secretion of oestradiol-17ß caused by dietary isoflavones could be a reason of silent heat in cows.
5
Content available remote

Genistein and daidzein affect in vitro steroidogenesis but not gene expression of steroidogenic enzymes in adrenals of pigs

84%
Kaminska B., Czerwinska J., Wojciechowicz B., Nynca A., Ciereszko R.
Journal of Physiology and Pharmacology
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2014
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tom 65
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nr 1
6
Content available remote

In vitro effects of genistein and daidzein on the activity of adrenocortical steroidogenic enzymes in mature female pigs

84%
Kaminska B., Ciereszko R., Kiezun M., Dusza L.
Journal of Physiology and Pharmacology
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2013
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tom 64
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nr 1
7

The influence of genistein on insulin, leptin, thyroid hormones and metabolic parameters in mature rats

84%
Nowicka-Stanczyk E., Szkudelski T., Szkudelska K., Nogowski L.
Journal of Animal and Feed Sciences
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2012
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tom 21
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nr 1
Genistein is a phytoestrogen and is found in many plants consumed by humans and animals. This isoflavone was found to exert metabolic effects, especially on lipid and carbohydrate metabolism. The aim of this experiment was to determine whether genistein at a dose of 1 and 5 mg/kg body weight administered intragastrically to male and female adult rats changes insulin, leptin, thyroid hormone, and metabolic parameters. The results suggest that genistein has only a slight influence on metabolism. A substantial reduction of triglyceride stores was observed in the skeletal muscles. This effect was sex-dependent and occurred only in females. Moreover, it was demonstrated that genistein at the higher dose decreased blood insulin and leptin levels.
8
Content available remote

Pharmacological agents and natural compounds: available treatments for osteoporosis

84%
Martiniakova M., Babikova M., Omelka R.
Journal of Physiology and Pharmacology
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2020
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tom 71
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nr 3
9

Effect of a mycooestrogen, zearalenone, and a phytooestrogen, coumestrol on the liver membrane insuline receptor of ovariectomized female rats

84%
Nogowski L., Mackowiak P., Nowak K. W.
Acta Biochimica Polonica
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1993
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tom 40
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nr 1
10

The influence of polychlorinated biphenyls [PCBs] and phytoestrogens in vitro on functioning of reproductive tract in cow

84%
Kotwica J., Wrobel M., Mlynarczuk J.
Reproductive Biology
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2006
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tom 06
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nr Suppl.1
11

Soyfem - valuable compound in therapy of menopausal symptoms

84%
Drews K., Seremak-Mrozikiewicz A.
Herba Polonica
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2007
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tom 53
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nr 2
12

A comparative study of the effects of genistein, estradiol and raloxifene on the murine skeletal system

67%
Sliwinski L., Folwarczna J., Nowinska B., Cegiela U., Pytlik M., Kaczmarczyk-Sedlak I., Trzeciak H., Trzeciak H. I.
Acta Biochimica Polonica
|
2009
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tom 56
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nr 2
261-270
Genistein, a major phytoestrogen of soy, is considered a potential drug for prevention and treatment of postmenopausal osteoporosis. The aim of the present study was to compare the effects of genistein, estradiol and raloxifene on the skeletal system in vivo and in vitro. Genistein (5 mg/kg), estradiol (0.1 mg/kg) or raloxifene hydrochloride (5 mg/kg) were administered daily by a stomach tube to mature ovariectomized Wistar rats for 4 weeks. Bone mass, mineral and calcium content, macrometric parameters and mechanical properties were examined. Also the effects of genistein, estradiol and raloxifene (10-9-10-7 M) on the formation of osteoclasts from neonatal mouse bone marrow cells and the activity of osteoblasts isolated from neonatal mouse calvariae were compared. In vivo, estrogen deficiency resulted in the impairment of bone mineralization and bone mechanical properties. Raloxifene but not estradiol or genistein improved bone mineralization. Estradiol fully normalized the bone mechanical properties, whereas genistein augmented the deleterious effect of estrogen-deficiency on bone strength. In vitro, genistein, estradiol and raloxifene inhibited osteoclast formation from mouse bone marrow cells, decreasing the ratio of RANKL mRNA to osteoprotegerin mRNA expression in osteoblasts. Genistein, but not estradiol or raloxifene, decreased the ratio of alkaline phosphatase mRNA to ectonucleotide pyrophosphatase phosphodiesterase 1 mRNA expression in osteoblasts. This difference may explain the lack of genistein effect on bone mineralization observed in ovariectomized rats in the in vivo study. Concluding, our experiments demonstrated profound differences between the activities of genistein, estradiol and raloxifene towards the osseous tissue in experimental conditions.
13

Expression changes of estrogen receptors alpha and beta in testis and epididymis of male mice under the influence of diet rich in phytoestrogens

67%
Sliwa L., Macura A. B.
Acta Biologica Cracoviensia. Series Botanica. Supplement
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2008
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tom 50
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nr 1
14
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Content available

Effect of phytoestrogen intake in the diet on lipid and sex hormone metabolism in menopausal women, and increased risk of breast cancer

67%
Kostrzewa-Tarnowska A., Czlapka-Matyasik M., Walkowiak J., Godlewski D.
Journal of Pre-Clinical and Clinical Research
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2015
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tom 09
|
nr 2
Introduction and objective. Phytoestrogens are one of nutritional factors exhibiting a chemoprotective action, potentially reducing vasomotor symptoms as well as cancerous lesions. The study was ocused on an association between the consumption of phytoestrogens in the diet, blood serum cholesterol concentration and urinary estrogen metabolites levels. Materials and methods. The study was conducted on 55 women in the perimenopausal period, who were characterized by an increased risk of hormone-dependent cancer. Energy and nutritive value of food rations, and especially the level of phytoestrogen consumption in the diets in the examined population, were analyzed using the Wikt Pro computer programme. Estrogen metabolites (2OHE, 16α-OHE1) were determined from 24‑urine samples by the ELISA method. The EMR index was calculated. Plasma total cholesterol concentrations was measured. Results and conclusions. The population with a higher consumption of phytoestrogens and dietary fibre in the diet, at the simultaneous slight limitation of energy value of the food ration, is characterized by an improved blood serum cholesterol concentration and an appropriate estrogen metabolism towards a significant increase in the estrogen index for the cancer lesions in the mammary glands.
15

Fitoestrogeny - wystepowanie w zywnosci

67%
Badowski P., Urbanek-Karlowska B.
Roczniki Państwowego Zakładu Higieny
|
2001
|
tom 52
|
nr 3
203-212
Na podstawie danych piśmiennictwa scharakteryzowano wybrane aspekty żywieniowe i zdrowotne u ludzi związane z naturalnym występowaniem w żywności fitoestrogenów - związków o działaniu estrogennym.
16
Content available remote

Effects of phytoestrogen daidzein and estradiol on steroidogenesis and expression of estrogen receptors in porcine luteinized granulosa cells from large follicles

67%
Nynca A., Jablonska O., Slomczynska M., Petroff B. K., Ciereszko R. E.
Journal of Physiology and Pharmacology
|
2009
|
tom 60
|
nr 2
95-105
The aims of the study were to compare the in vitro effects of daidzein or 17ß-estradiol (E2) on: 1) progesterone (P4) secretion by luteinized granulosa cells harvested from large porcine follicles, as well as 2) estrogen receptor and ß (ER and ERß) mRNA and protein expression in the cells. In addition, the effect of daidzein on E2 secretion and viability of the granulosa cells was examined. We found that basal and gonadotropin-stimulated P4 secretion were inhibited in granulosa cells cultured in the presence of daidzein either for 24 or 48 hours. In contrast to daidzein, E2 reduced P4 secretion only during 24-hour cell cultures increasing it during longer cultures. Daidzein did not affect E2 secretion by granulosa cells. The expression of ER and ERß mRNA, as well as ERß protein, was up-regulated by daidzein but unaffected by E2. To conclude, the soy estrogen daidzein acts directly on the porcine ovary to decrease progesterone production and to increase expression of ERß mRNA and protein. Daidzein actions in porcine luteinized granulosa cells differ from those of estradiol and it may suggest disadvantageous effects of the phytoestrogen on reproductive processes in females.
17

Estrogen receptors - state of art

67%
Popiela A., Panszczyk M., Gabrys M., Borzecki A., Slomczynska M., Baranowski W.
Polish Journal of Environmental Studies
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2004
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tom 13
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nr Suppl.2, Part 1
Authors performed a review of a current literature related with a structure, physiology and effects of estrogen receptor function. Our article contains information about molecular structure of SHR family (steroid hormone receptors), a way of binding with their ligands. We tried to present step by step a mechanism of receptor reaction with nucleic acids also a mechanism of initiation of transcription. We clearly described a function and action of cofactor proteins in a process of receptor activation. We mentioned about fitoestro- gens influence on estrogen receptor molecules.
18

Rosliny jako zrodlo naturalnych substancji szkodliwych dla zdrowia

67%
Czerwiecki L.
Roczniki Państwowego Zakładu Higieny
|
2005
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tom 56
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nr 3
215-227
Omówiono wybrane substancje szkodliwe oraz toksyczne wytwarzane przez rośliny wyższe oraz bytujące w środowisku wodnym (glony). Zwrócono uwagą na wielokierunkowe działanie na organizm ludzki omawianych związków i ich przemiany.
19

Choroba koniczynowa

67%
Kwiatkowski T., Pres J.
Biuletyn Informacyjny. Instytut Zootechniki
|
1996
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tom 34
|
nr 1
19-25
20

Wplyw fitoestrogenow pokarmowych na organizm czlowieka. Cz.I. Wystepowanie fitoestrogenow w zywnosci oraz ich metabolizm

67%
Prescha A., Biernat J.
Bromatologia i Chemia Toksykologiczna
|
2008
|
tom 41
|
nr 3
209-214
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