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Content available

Can Nidogen-1 and Nidogen-2 improve our preoperative cancer detection rate?

100%
Kwiatkowska A., Krawczyk D., Kulak K.
Journal of Pre-Clinical and Clinical Research
|
2021
|
tom 15
|
nr 2
2

Laminin as promoter of the neural development

100%
Wozniak W., Bruska M.
Folia Morphologica
|
1990
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tom 49
|
nr 3-4
3

Deconstructing B cell tolerance to basement membranes

100%
Foster M. H., Zhang Y., Clark A. G.
Archivum Immunologiae et Therapiae Experimentalis
|
2006
|
tom 54
|
nr 4
4

Insulin-like growth factor-I increases laminin, integrin subunits and metalloprotease ADAM12 in mouse myoblasts

84%
Grzelkowska-Kowalczyk K., Grabiec K., Tokarska J., Gajewska M., Blaszczyk M., Milewska M.
Folia Biologica
|
2015
|
tom 63
|
nr 4
5

Transdifferentiation of bone marrow mesenchymal stem cells into the islet-like cells: the role of extracellular matrix proteins

84%
Pokrywczynska M., Lewandowska M. A., Krzyzanowska S., Jundzill A., Rasmus M., Warda K., Gagat M., Deptula A., Helmin-Basa A., Holysz M., Nowacki M., Buchholz L., Bodnar M., Marszalek A., Grzanka A., Jozwicki W., Michalkiewicz J., Drewa T.
Archivum Immunologiae et Therapiae Experimentalis
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2015
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tom 63
|
nr 5
6

Involvement of MMPs in delayed neuronal death after global ischemia

84%
Zalewska T., Ziemka-Nalecz M., Sarnowska A., Domanska-Janik K.
Acta Neurobiologiae Experimentalis
|
2002
|
tom 62
|
nr 2
7
Content available remote

Desmosealin and other components of the epidermal extracellular matrix

67%
Sandjeu Y., Haftek M.
Journal of Physiology and Pharmacology. Supplement
|
2009
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tom 60
|
nr 4
8

Cytokeratin-18 and hyaluronic acid levels predict liver fibrosis in children with non-alcoholic fatty liver disease

67%
Lebensztejn D. M., Wierzbicka A., Socha P., Pronicki M., Skiba E., Werpachowska I., Kaczmarski M.
Acta Biochimica Polonica
|
2011
|
tom 58
|
nr 4
Objectives: There is a need to replace liver biopsy with non-invasive markers that predict the degree of liver fibrosis in fatty liver disease related to obesity. Therefore, we studied four potential serum markers of liver fibrosis and compared them with histopathological findings in liver biopsy in children with non-alcoholic fatty liver disease (NAFLD). Methods: We determined fasting serum level of hyaluronic acid (HA), laminin, YKL-40 and cytokeratin-18 M30 in 52 children (age range 4-19, mean 12 years, 80 % of them were overweight or obese) with biopsy-verified NAFLD. Viral hepatitis, autoimmune and metabolic liver diseases (Wilson's disease, alpha-1-antitrypsin deficiency, cystic fibrosis) were excluded. Fibrosis stage was assessed in a blinded fashion by one pathologist according to Kleiner. Receiver operating characteristics (ROC) analysis was used to calculate the power of the assays to detect liver fibrosis (AccuROC, Canada). Results: Liver fibrosis was diagnosed in 19 children (37 %). The levels of HA and CK18M30 were significantly higher in children with fibrosis compared to children without fibrosis (p=0.04 and 0.05 respectively). The ability of serum HA (cut-off 19.1 ng/ml, Se=84 %, Sp=55 %, PPV=52 %, NPV=86 %) and CK18M30 (cut-off 210 u/l, Se=79 %, Sp=60 %, PPV=56 %, NPV=82 %) to differentiate children with fibrosis from those without fibrosis was significant (AUC=0.672 and 0.666, respectively). The combination of both markers was superior (AUC=0.73, p=0.002). Laminin and YKL-40 levels did not allow a useful prediction. Conclusions: Cytokeratin-18 and hyaluronic acid are suitable serum markers predicting liver fibrosis in children with NAFLD. Studying these markers may identify patients at risk of disease progression.
9

Adhesion properties of human bladder cell lines with extracellular matrix components: the role of integrins and glycosylation

67%
Litynska A., Przybylo M., Pochec E., Laidler P.
Acta Biochimica Polonica
|
2002
|
tom 49
|
nr 3
Integrin subunits present on human bladder cells displayed heterogeneous func­tional specificity in adhesion to extracellular matrix proteins (ECM). The non-malignant cell line (HCV29) showed significantly higher adhesion efficiency to collagen IV, laminin (LN) and fibronectin (FN) than cancer (T24, Hu456) and v-raf transfected (BC3726) cell lines. Specific antibodies to the a2, a5 and β1 integrin sub- units inhibited adhesion of the non-malignant cells, indicating these integrin partici­pation in the adhesion to ECM proteins. In contrast, adhesion of cancer cells was not inhibited by specific antibodies to the β1 integrin subunit. Antibodies to a3 integrin in­creased adhesion of cancer cells to collagen, LN and FN, but also of the HCV29 line with colagen. It seems that a3 subunit plays a major role in modulation of other integrin receptors especially in cancer cells. Differences in adhesion to ECM proteins between the non-malignant and cancer cell lines in response to Gal and Fuc were not evident, except for the v-raf transfected cell line which showed a distinct about 6-fold increased adhesion to LN on addition of both saccharides. .-Acetylneuraminic acid inhibited adhesion of all cell lines to LN and FN irrespective of their malignancy.
10

Ultrastructural studies on selected elements of the extracellular matrix in the developing rat lung alveolus

67%
Wasowicz M., Biczysko W., Marszalek A., Yokoyama S., Nakayama I.
Folia Histochemica et Cytobiologica
|
1998
|
tom 36
|
nr 1
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