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Septal papillary muscles, similarly to other papillary muscles, are essential elements of the heart valvular system. Damage to their structure may lead to a considerable life risk. Of all the papillary muscles, the septal papillary muscles are characterized by the greatest topographical and morphological variability. However, information about these muscles is scarce and fragmentary. The objective of this study was to ascertain their occurrence and the region in which they are placed in the inter-ventricular septum. One hundred and eleven human hearts were examined. The hearts belonged to the Clinical Anatomy Department of the Medical University of Gdańsk. They were fixed in formalin with ethanol and came from middle-aged and older individuals of both sexes, devoid of pathological changes and birth defects. During the tests, classic anatomical methods were applied. The region where the papillary muscles are found covers a sizeable surface of the septum, from the conus arteriosus up to the back angle of the right chamber. Depending on their location the following septal papillary muscles (musculi papillares septales, MPS) were singled out: 1) lying on the front wall of the septum (anterior papillares septales), 2) in the central part of the septum (central muscles), and 3) in the posterior section of the septum (posterior papillares septales). A trial to determine the types of MPS was based on this diversity of location. Consequently, five types of MPS were specified: type I: anterior–central (44.1%); type II: anterior (15.3%); type III: anterior–posterior (13.5%); type IV: anterior–central–posterior (24.3%); and type V: uniform (2.75%). This study is an attempt to systematize and standardize the terminology of these structures. (Folia Morphol 2010; 69, 2: 101–106)
The septomarginal trabecula is present in all human hearts as well as in the hearts of other primates. It usually connects the interventricular septum with the anterior papillary muscle, although there are many variations in how this is achieved. The object of the analyses was to estimate the bilateral topography of the septomarginal trabecula and the anterior papillary muscle in the context of the ontogeny and phylogeny of primates. A total of 138 hearts were examined from number of different non-human primates. The presence of the septomarginal trabecula was confirmed in 94.9% of cases, although not in the hearts of Lemur varius. Four configurations could be distinguished by defining the location of the septomarginal trabecula and its relation to the anterior papillary muscle. For the hearts of the Strepsirrhini and the majority of Platyrrhini neither structure was related, whereas in all examined representatives of Hominoidea they had fused and created morphologically varying forms. On the basis of these results, a concept was developed for the sequence of changes which the topography of the septomarginal trabecula and the anterior papillary muscle undergo during ontogeny and phylogeny. (Folia Morphol 2013; 72; 3: 202–209)
In addition to the papillary muscles of right ventricle referred to in anatomical nomenclature, namely the anterior, posterior and septal, we have distinguished the “conal papillary muscle” and the “papillary muscle of the posterior angle of the right ventricle”. The conal papillary muscle was described by Luschka in the 17th century as the most constant of the septal papillary muscles. We have distinguished the muscles of the posterior angle of the right ventricle as muscles which would not be clearly classified as either septal or posterior muscles. Moreover, the muscles of the posterior angle of the right ventricle are probably associated with the transfer of the papillary muscles from the septum to the posterior wall of the right ventricle during phylogenetic evolution. Some researchers have classified them with the septal papillary muscles [11, 12], while others have assigned them to the posterior group [5]. The morphology of the muscles was classified using earlier categories for the posterior papillary muscles only. We have adopted the concept of multi-apical and multi-segmental muscles [5].
The inferior vena cava, also known as the posterior vena cava, is the large vein that carries de-oxygenated blood from the lower half of the body into the right atrium of the heart. Congenital anomalies of the inferior vena cava result from the persistence of the embryonic venous system. The majority of cases are clinically silent and are diagnosed in routine dissection studies, in retroperitoneal surgeries, or through imaging for other reasons. Although these anomalies are rare, they are of great importance during operations in the abdominal area or in the treatment of thromboembolic diseases. We report two cases of double vena cava and left vena cava, respectively, and a short review of the relevant literature. (Folia Morphol 2010; 69, 3: 123–127)
Basic regulatory properties of the 2-oxoglutarate dehydrogenase complex (OGDC) isolated and purified from the heart muscle of European bison (Bison bonasus) were studied. Kinetic studies have shown that in the absence of phosphate ions OGDC exhibits kinetic attributes of negative cooperativity with respect to 2-oxoglutarate. ADP and phosphate lower So.5 value of OGDC for 2-oxoglutarate without changing the maximum reaction rate. NADH inhibits OGDC versus both 2-oxoglutarate and NAD+. Moreover, bison heart OGDC shows negative kinetic cooperativity for NAD+ and positive kinetic cooperativity for CoA at low CoA concentrations. The latter property has not been observed in earlier studies on OGDC from bovine and pig heart and other tissues of these animals.
The observational results of the morphology of the coronary sinus valve are presented in this study. Research was condyucted on material consisting of l00 adult human hearts of both sexes from l8 to 87 years of age. Basic morphological types of the examined structure are distiguished and the main traits regarding their histological nature are presented.
The supraventricular crest is a fleshy trabecula of the right ventricle that has an important function in guiding the blood flow. However, controversy persists regarding its anatomical constitution. In this study, we aimed to investigate its frequency, formation, termination, morphometry, and relationships with the septomarginal trabecula, septal papillary muscle, right atrioventricular ring, and left posterior semilunar valve of the pulmonary trunk valve. Our material consisted of 50 hearts from adult individuals of both sexes that had been preserved in 10% formalin. They were opened along the arterial cone by means of an incision starting at the pulmonary trunk and ending at the right margin. The supraventricular crest was always present. The marginal (right) extremity was formed by two to six muscle bundles that joined together (88%). On the septal (left) side, the single muscle bundle penetrated the interventricular septum directly (88%) or by means of two or three divisions (12%). It could form a septal band (52%) and could pass over the septal papillary muscle (43.5%) or just below it (34.8%). There was a relationship of muscle fibres between these two structures in 64% of cases. Dissection of the septal band demonstrated continuity with the septomarginal trabecula (46%). In 80% of cases, the crest was connected to the right atrioventricular ring and it participated in its outline directly (64%) or by means of muscle expansions (16%). Its muscle fibres bordered the left semilunar valve of the pulmonary valve in 50% of cases. Regarding morphometry, we observed that the length varied little with increasing weight of the heart (22.6%), but the height and width increased markedly with increasing weight of the heart. (Folia Morphol 2010; 69, 1: 42–46)
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Under the condition of rapid perfusion, the time course of contractile response of single ventricular cells to extracellular calcium (Ca) depletion and repletion identifies „fast” and „slow” cellular Ca pools. ⁴⁵Ca exchange was studied in these cells under the same conditions of on-line rapid perfusion. Four kinetically-defined compartments were distinguished: (1) A „rapid” compartment containing 2.6mmoles Ca/kg dry wt of lanthanum (La) displaceable Ca, t½ < 1 sec.; (2) An „intermediate” compartments) containing 2.1 mmoles, t½ = 3 and 19 sec. Caffeine displaced significant amounts of Ca from this compartment whereas La displaced none; (3) A „slow” compartment containing 1.6 mmoles, t½ = 3.6 min. Addition of inorganic phosphate to the perfusate adds significant amounts of Ca to this compartment; (4) An „inexchangeable” compartment, containing 1.2 mmoles. The „rapid” compartment’s flux is > 300 µmoles Ca/kg wet wt/sec. Its exchange rate indicates that it is the kinetic counterpart of the functionally-defined „fast” pool. Its subcellular locus is undefined. The „intermediate” compartment is best correlated with the „slow” pool and represents Ca in the sarcoplasmic reticulum. The „slow” compartment contains a significant fraction from the mitochondria. The results indicate that > 40% of cellular Ca can turn over within the period of one contraction cycle. These results are consistent with the following sequence: (1) Upon sarcolemmal depolarization, Ca moves through the Ca channel to arrive at the SR and at the myofilaments. (2) Ca induced Ca release occurs via the „feet” at the SR-inner SL region. The Ca diffuses to the myofilaments or is transported across the SL via the Na-Ca exchanger. (3) Ca is pumped into the free or longitudinal SR and diffuses to the cistemae. Ca is pumped across the SL by the SL Ca pump and by the Na-Ca exchanger. (4) Mitochondrial Ca exchange via the Na-Ca exchanger and/or SL Ca pump. (Supported by NHLBI and the Laubisch and Castera Endowments.)
Background: Congenital heart diseases (CHD) are the leading cause of birth defect-related deaths. Multidedector computed tomography (MDCT) plays an important role for imaging CHD in addition to echocardiography and provides a comprehensive evaluation of complex heart malformations for the referring cardiologist. The aim of the study was to evaluate the utility of MDCT in the assessment of CHD. Materials and methods: A 102 patients with CHD were investigated after initial assessment by echocardiography. The information obtained by MDCT and findings of echocardiography were reviewed together by paediatric cardiologists and cardiac radiologists. Perioperative anatomic descriptions, wherever available (n = 34) formed the gold standard for the comparison. Results: The clinical consensus diagnosis defined 154 cardiovascular lesions in the patients. The results were classified in groups. We present the appearance of various congenital cardiac lesions seen in clinical practice. Conclusions: MDCT provides important information about anatomic details of CHD for the referring cardiologist. The evaluation of different anatomic structures such as heart, great vessels, lungs and abdomen is possible in one acquisition with this technique. (Folia Morphol 2013; 72, 3: 188–196)
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