Ograniczanie wyników

Czasopisma help
Autorzy help
Lata help
Preferencje help
Widoczny [Schowaj] Abstrakt
Liczba wyników

Znaleziono wyników: 303

Liczba wyników na stronie
Pierwsza strona wyników Pięć stron wyników wstecz Poprzednia strona wyników Strona / 16 Następna strona wyników Pięć stron wyników wprzód Ostatnia strona wyników

Wyniki wyszukiwania

Wyszukiwano:
w słowach kluczowych:  chromosome
help Sortuj według:

help Ogranicz wyniki do:
Pierwsza strona wyników Pięć stron wyników wstecz Poprzednia strona wyników Strona / 16 Następna strona wyników Pięć stron wyników wprzód Ostatnia strona wyników
The distribution of (A,T)-rich regions has been investigated on a 835kb DNA fragment (D835), from the Drosophila X sex chromosome, unsequenced but provided with detailed physical maps for restriction enzymes-recognizing (A,T)- or (C,G)- or (mixte)-motifs, and on several sequenced DNA fragments, 100-600 kb long, from the autosomal chromosomes. Numerous (A,T)-rich regions are present in all DNA fragments. Their size varies from 0.2 kb to several kb in all cases, except for D835 where some of them extend to 20-30 kb. The relationship between these (A,T)-rich regions and several chromosome landmarks has been examined in the particular case of D835. Topo II in-vitro sites are randomly distributed with regard to (A,T)-richness. However, transcription units and repeated regions are significantly localized outside (A,T)-rich regions. On the opposite, SARs and ARSs are mostly localized within (A,T)-rich regions. Lastly, topo II in-vivo sites are almost exclusively localized in (A,T)-rich regions. Speculations are proposed on why and how (A,T)-rich regions may have appeared during the emergence of Drosophila genome from a primitive genome.
Until recently marker chromosomes have presented a difficult diagnostic problem for cytogeneticists as well as for clinicians. Introduction of FISH to cytogenetic analysis has enabled identification of their origin giving possibility to outline specific phenotypic effects of defined marker chromosomes. Nine marker chromosomes were analysed with FISH using centromeric probes, chromosome- specific libraries and unique DNA sequences probes for PWS/AS critical region. The origin from acrocentric chromosomes was established in 6 cases. One marker was a product of maternal 11;22 translocation and two others were pericentromeric regions of chromosome 2 and 4. Among 6 markers, derived from acrocentric chromosomes, 2 consisted of pericentromeric part of chromosome 15, one was identified as mar (21) and in 3 other cases the origin could not be differentiated between chromosomes 13 and 21 or 14 and 22. Clinical consequences of marker chromosomes including the risk for chromosomal nondisjunction and trisomy 21 as well as the risk for uniparental disomy (UPD) are discussed.
Pierwsza strona wyników Pięć stron wyników wstecz Poprzednia strona wyników Strona / 16 Następna strona wyników Pięć stron wyników wprzód Ostatnia strona wyników
JavaScript jest wyłączony w Twojej przeglądarce internetowej. Włącz go, a następnie odśwież stronę, aby móc w pełni z niej korzystać.