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Introduction. Metastatic renal cell carcinoma can spread from the primary renal cell carcinoma to other organs, practically to all tissues. Distant metastases – to the tissue of the head and neck – are transferred through the blood and lymph vessels. A case of such a metastasis localized on the palate is relatively rare and therefore poses interesting material for description. Objective. Analysis of a case of cell renal carcinoma meastasis of the palate in a 67-year-old patient, based on clinical observations and medical publications. Conclusion. Clear cell carcinoma metastases to distant organs are often the first sign of a covertly progressing disease of which the primary tumour is localized in the kidney. The treatment is surgical, and prognosis is poor in the case of distant metastases since tumours recur even after a few years.
Sebaceous glands have been extremely rare findings in the female genital system. Excluding the vulva and recent findings, very few cases have been described. The origin of the lesions remains a topic of speculation. However, it appears that prolonged irritation induces a metaplastic response in the ectocervical epithelium. A new case of sebaceous glands in the ectocervix of a 46-year-old woman is reported. The lesions were unexpectedly found in a hysterectomy specimen. The procedure was carried out for multiple leiomyomas of the uterine corpus. Histological examination revealed three mature sebaceous glands located distally to the transformation zone, which opened directly onto the surface epithelium. It could be concluded that sebaceous glands in the ectocervix are rare lesions of unclear origin and low clinical significance. However, the glands could potentially be associated with sebaceous carcinoma of that anatomical site. (Folia Morphol 2009; 68, 4: 287–289)
Enhanced fucosyltransferase IV (FUT4) expression correlates with increased tumor malignancy in many carcinomas. However, little is known about the regulation of FUT4 expression, and whether FUT4 expression is influenced by the methylation status of the FUT4 promoter is unclear. In this study, we demonstrated that FUT4 expression is negatively correlated with the methylation degree of a CpG island in the FUT4 promoter, suggesting that the methylation status of FUT4 promoter regulates the expression of FUT4. The results indicate that manipulating the methylation status of the FUT4 promoter to regulate FUT4 expression may be a novel approach in the treatment of malignant tumors.
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