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Therapeutical effect of modified adamantane copolymer compounds: Study of molecular mechanisms

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Rybalko S., Nesterova N., Diadiun S., Danylenko G., Danylenko V., Guzhova S., Maksimov Y., Arkadiev V., Ivans'ka N., Maksymenok O., Vrnycianu N., Zhtrebtsova E., Grygoreva T.

Acta Biochimica Polonica

2001

tom 48

nr 1

Copolymers of N-polyvinylpyrrolidone-acrylic acid (AB-1) and adamantane derivatives are known to possess marked antiviral activity in in vitro and in ovo models. Among the constructed preparations of AB-1 modified by adamantane derivatives some, especially AB-4 (modified by deitiforin), were found to show more extended antiviral activity and to inhibit markedly virus reproduction in susceptible permissive cell cultures and chicken embryos. In AB-4 treated cells and allantoic sacs, virus titers (influenza virus, herpes virus, and HIV) and virus antigen concentration were decreased. On the other hand, herpes virus-specific thymidine kinase and of DNA-polymerases isolated from Escherichia coli, Plectonema boryanum, and herpes virus type 1 infected murine brain tissue retained their activity after incubation with AB-4 or AB-2. The compounds investigated, in view of their effect on virus reproduction, are thought to be prospective as antiviral agents.

Ograniczanie wyników

1 Acta Biochimica Polonica

1 Arkadiev V.

1 Danylenko G.

1 Danylenko V.

1 Diadiun S.

1 Grygoreva T.

1 Guzhova S.

1 Ivans'ka N.

1 Maksimov Y.

1 Maksymenok O.

1 Nesterova N.

1 Rybalko S.

1 Vrnycianu N.

1 Zhtrebtsova E.

1 2001

Wyniki wyszukiwania

Therapeutical effect of modified adamantane copolymer compounds: Study of molecular mechanisms