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Impact of nine month health training and a single exercise on changes in ghrelin, leptin and free fatty acids levels in women’s blood

100%

Murawska-Cialowicz E., Wierzbicka-Damska I., Bakonska-Pacon E., Kalwa M., Dziegiel P.

Central European Journal of Sport Sciences and Medicine

2015

tom 09

nr 1

The aim of the research was to assess changes in ghrelin, leptin and free fatty acids (FFA) levels in women’s blood after training. The research was carried out in women aged 45.55 ±11.33 years and with the BMI of 26.49 ±4.49. Health training at 50–66% VO2max took place twice a week for 9 months. In the baseline phase and in the 3rd, 6th and 9th month of the training, body mass and composition were measured, cardiorespiratory fitness was checked after a 10-minute exercise test on a cycloergometer, and fasting levels of ghrelin, leptin and FFA in the serum were assayed and 15 minutes after the exercise test. Body mass was reduced in the 6th month of the training. Fasting ghrelin level increased because of training, leptin and FFA decreased. After single 10-minute exercises performed every 3 months level of ghrelin and FFA increased while leptin decreased. An increase in ghrelin level in the blood after the single exercise can be the result of negative energy expenditure. An increase in fasting ghrelin level after training can be one of the adaptive physiological mechanisms connected with energy saving. A mechanism that is switched on as a result of a long-lasting stimulus that leads to energy losses, reduction in body mass and a decrease in leptin level in the blood.

Melatonin decreases homocysteine level in blood of rats

86%

Murawska-Cialowicz E., Januszewska L., Zuwala-Jagiello J., Milczarska J., Zawadzki M., Paprocka-Borowicz M., Wierzbicka-Damska I.

Journal of Physiology and Pharmacology

2008

tom 59

nr 4

717-729

Elevated plasma homocysteine level promotes atherosclerosis in blood vessels due to, among others, generation of reactive oxygen species and reduction of nitric oxide bioavailability. The aim of this study was to investigate whether melatonin administration reduces plasma homocysteine level in rats consuming increased doses of methionine in the diet. The trial lasted for two months. The rats were divided into a few groups - 2 groups consisted of animals fed a standard diet, 2 groups consisted of animals fed a diet rich in methionine for one and two months, a group which had methionine removed from the diet in the second month, a group which had methionine removed from the diet and melatonin administered in the second month, a group still fed a diet rich in methonine in the second month and also given melatonin, and a group of animals on a diet rich in methionine for two months and given melatonin at the same time. Hcy, lipid peroxidation markers (MDA+4HNE) and nitric oxide metabolite (NO2-/NO3-) concentrations were determined in the plasma of all the rats. As a result of the tests it was found that plasma Hcy concentration increases in the first month of a methionine-rich diet but then decreases in the second month. MDA+4HNE changes are similar. Melatonin significantly intensifies the effects. The changes of NO2-/NO3- concentrations were noticed especially in the groups receiving melatonin. Elimination of methionine from the feed does not change the value of NO2-/NO3-. NO production increases only after administration of melatonin. On the basis of received results it might be stated that melatonin administration together with a methionine-rich diet significantly decreases Hcy concentration, the level of oxidative stress and increases NO production. It might have some practical implications, especially when the level of endogenous melatonin decreases e.g. in elderly people or people with hyperhomocysteinemia.

Ograniczanie wyników

1 Central European Journal of Sport Sciences and Medicine

1 Journal of Physiology and Pharmacology

2 Murawska-Cialowicz E.

2 Wierzbicka-Damska I.

1 Bakonska-Pacon E.

1 Dziegiel P.

1 Januszewska L.

1 Kalwa M.

1 Milczarska J.

1 Paprocka-Borowicz M.

1 Zawadzki M.

1 Zuwala-Jagiello J.

1 2015

1 2008

Wyniki wyszukiwania

Impact of nine month health training and a single exercise on changes in ghrelin, leptin and free fatty acids levels in women’s blood

Melatonin decreases homocysteine level in blood of rats