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1
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Tussigenic agents in the measurement of cough reflex sensitivity

100%
Pecova R., Javorkova N., Kudlicka J., Tatar M.
Journal of Physiology and Pharmacology. Supplement
|
2007
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tom 58
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nr 5
2
Content available remote

Changes of cough reflex sensitivity induced by cancer radiotherapy of chest and neck regions

76%
Javorkova N., Hajtmanova E., Kostkova L., Zamecnik L., Pecova R., Hanacek J., Tatar M.
Journal of Physiology and Pharmacology. Supplement
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2006
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tom 57
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nr 4
157-163
It is reasonable to suppose that airway mucosa can be damaged by irradiation applied to chest and neck regions. The inflammatory process is a consequence of an injury. Airway inflammation is one mechanism responsible for cough induction. So, one can suppose that radiotherapy (RT) focused on the patients' chest or neck may injure airway mucosa, which might change sensitivity of the nerve-endings mediating the cough reflex. The purpose of this study was to examine cough reflex sensitivity (CRS) in patients who underwent RT in the chest and neck regions. CRS test using capsaicin was performed in patients with breast cancer (Group A, n=19), and with lung or neck cancer in (Group B, n=14) who underwent RT. Capsaicin aerosol in doubled concentrations (0.49-1000 µM) was inhaled by a single breath. CRS was defined as the lowest capsaicin concentration that evoked 2 or more coughs (C2). Radiation doses ranged from 40 to 70 Gy. Capsaicin cough challenge was performed before and then in the 2nd and 5th week of RT. We observed a significantly reduced value of C2, i.e., increased cough reflex sensitivity, in Group B in the 2nd week of RT (P= 0.04). We conclude that CRS in the lung or neck cancer patients undergoing RT is significantly enhanced, which could result from injury to the nerve endings in airway mucosa.
3
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Influence of chest gamma-irradiation on cough response in awake guinea pigs

76%
Brozmanova M., Javorkova N., Hajtmanova E., Zamecnik L., Javorka M., Hanacek J., Tatar M.
Journal of Physiology and Pharmacology. Supplement
|
2007
|
tom 58
|
nr 5
4
Content available remote

Effects of thorax irradiation on citric acid-induced cough in guinea pigs

64%
Javorkova N., Brozmanova M., Hajtmanova E., Zamecnik L., Bartos V., Plank L., Javorka M., Hanacek J., Tatar M.
Journal of Physiology and Pharmacology. Supplement
|
2006
|
tom 57
|
nr 4
149-156
Thoracic irradiation may cause an acute lymphocytic alveolitis or hypersensitivity pneumonitis. It is well known that cough reflex is sensitized by a number of inflammatory mediators. The purpose of the present study was to investigate the effect of the thoracic irradiation on the cough response in awake guinea pigs. Guinea pigs (Trik strain) were exposed to sham irradiation (n=16), a single irradiation dose of 10 Gy (n=12), and a fractionated irradiation dose (in five fractions) of 15 Gy (n=12) delivered to the thorax. Cough was induced by citric acid aerosol inhalation in gradually increasing concentrations (0.05-1.6 M) during the first week after thoracic irradiation. The cough response was expressed as a total number of coughs induced during all citric acid challenges. Irradiated animals with single dose of 10 Gy exhibited a time- dependent significant increase of citric acid-induced cough in the 6th day after irradiation compared with control animals (P=0.005), whereas cough was not altered significantly in irradiated animals with fractionated dose of 15 Gy. This study demonstrates that the increased cough response may be a determinant of the functional changes of airway nerve-endings mediating cough in the early phase after thoracic irradiation.
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