Wyniki wyszukiwania

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Altitude adaptation through hematocrit changes

100%

Zubieta-Calleja G. R., Paulev P.-E., Zubieta-Calleja L., Zubieta-Castillo G.

Journal of Physiology and Pharmacology. Supplement

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2007

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tom 58

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nr 5

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Non-invasive measurement of circulation time using pulse oximetry during breath holding in chronic hypoxia

100%

Zubieta-Calleja G. R., Zubieta-Castillo G., Paulev P.-E., Zubieta-Calleja L.

Journal of Physiology and Pharmacology. Supplement

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2005

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tom 56

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nr 4

251-256

Pulse oximetry during breath-holding (BH) in normal residents at high altitude (3510 m) shows a typical graph pattern. Following a deep inspiration to total lung capacity (TLC) and subsequent breath-holding, a fall in oxyhemoglobin saturation (SaO2) is observed after 16 s. The down-pointed peak in SaO2 corresponds to the blood circulation time from the alveoli to the finger where the pulse oximeter probe is placed. This simple maneuver corroborates the measurement of circulation time by other methods. This phenomenon is even observed when the subject breathes 88% oxygen (PIO2 = 403 mmHg for a barometric pressure of 495 mmHg). BH time is, as expected, prolonged under these circumstances. Thus the time delay of blood circulation from pulmonary alveoli to a finger is measured non-invasively. In the present study we used this method to compare the circulation time in 20 healthy male high altitude residents (Group N with a mean hematocrit of 50%) and 17 chronic mountain sickness patients (Group CMS with a mean hematocrit of 69%). In the two study groups, the mean circulation time amounted to 15.94 ±2.57 s (SD) and to 15.66 ±2.74 s, respectively. The minimal difference was not significant. We conclude that the CMS patients adapted their oxygen transport rate to the rise in hematocrit and blood viscosity.

3

Hypoventilation in chronic mountain sickness: a mechanism to preserve energy

88%

Zubieta-Calleja G. R., Paulev P.-E., Zubieta-Calleja L., Zubieta-Calleja N., Zubieta-Castillo G.

Journal of Physiology and Pharmacology. Supplement

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2006

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tom 57

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nr 4

425-430

Chronic Mountain Sickness (CMS) patients have repeatedly been found to hypoventilate. Low saturation in CMS is attributed to hypoventilation. Although this observation seems logical, a further understanding of the exact mechanism of hypoxia is mandatory. An exercise study using the Bruce Protocol in CMS (n = 13) compared to normals N (n = 17), measuring ventilation (VE), pulse (P), and saturation by pulse oximetry (SaO2) was performed. Ventilation at rest while standing, prior to exercise in a treadmill was indeed lower in CMS (8.37 l/min compared with 9.54 l/min in N). However, during exercise, stage one through four, ventilation and cardiac frequency both remained higher than in N. In spite of this, SaO2 gradually decreased. Although CMS subjects increased ventilation and heart rate more than N, saturation was not sustained, suggesting respiratory insufficiency. The degree of veno-arterial shunting of blood is obviously higher in the CMS patients both at rest and during exercise as judged from the SaO2 values. The higher shunt fraction is due probably to a larger degree of trapped air in the lungs with uneven ventilation of the CMS patients. One can infer that hypoventilation at rest is an energy saving mechanism of the pneumo-dynamic and hemo-dynamic pumps. Increased ventilation would achieve an unnecessary high SaO2 at rest (low metabolism). This is particularly true during sleep.

Ograniczanie wyników

3 Journal of Physiology and Pharmacology. Supplement

3 Paulev P.-E.

3 Zubieta-Calleja G. R.

3 Zubieta-Calleja L.

3 Zubieta-Castillo G.

1 Zubieta-Calleja N.

1 2007

1 2006

1 2005

Altitude adaptation through hematocrit changes

Non-invasive measurement of circulation time using pulse oximetry during breath holding in chronic hypoxia

Hypoventilation in chronic mountain sickness: a mechanism to preserve energy