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Influence of lead on growth and nutrient accumulation in Black gram (Vigna mungo L.)

100%

Ravikumar S., Thamizhiniyzn P.

International Letters of Natural Sciences

2014

tom 16

This study was conducted to investigate toxic effects of Pb on growth and nutrient uptake in Black gram. Black gram was subjected to seven (5, 10, 25, 50, 75, 100 & 200 kg-1) levels of lead. Due to Pb toxicity, plant growth was adversely affected and relatively a severe reduction in root biomass was recorded. The Pb accumulation increased with the increase in lead concentrations. The uptake of different nutrients, i.e., N, P, K, Ca and Mg was reduced in black gram due to the lead treatment.

A proteomics approach to identify the differential protein level in cardiac muscle of diabetic rat

80%

Karthik D., Vijayakumar R., Pazhanichamy K., Ravikumar S.

Acta Biochimica Polonica

2014

tom 61

nr 2

Background: Cardiovascular proteomics investigation reveals the characterization and elucidation of the novel therapeutic targets and strategies to prevent the development of heart failure associated diabetic complication by using 2DE and MS. Methods: The experimental animals were made diabetic with a single intraperitoneal injection of alloxan (150 mg/kg of bw). Albino rats were randomly divided into four individual groups: Group-I control (n=6), group-II alloxan-induced diabetic rats, untreated (n=6), group-III (n=6) and group-IV (n=6) alloxan-induced diabetic rats were treated with aqueous and ethanolic extracts of Cynodon dactylon for 15 days, respectively. Animals were euthanized to collect the heart tissues and blood samples. 2DE sample preparation, gel running and staining (n=6: each groups) were performed at the same time to avoid variation. The result of six gel images from each group were analyzed and evaluated as one match set with 2D software (P<0.05). Results: The above experiment revealed two up-regulated proteins in group-II i.e. NTF4 and ETFB. Conclusions: NTF4 is a neuro-protective agent for neuro-degenerative diseases. It will prevent diabetic secondary complications, such as diabetic polyneuropathy and cardiomyopathy. ETFB is active in the mitochondria, the energy-producing centres in cells. It is clear from the experiment that because of up-regulation of ETFB more energy is availabile and the electron transfer for heart during diabetes is possible, what leads to reduce the oxidative stress and free-radical formation. The up-regulated proteins reduced CVD that occurred just before overt hyperglycaemia due to administration of C. dactylon. This approach established the preliminary reference map for decoding cellular mechanisms linked between pathogenesis CVD and diabetes.

Ograniczanie wyników

1 Acta Biochimica Polonica

1 International Letters of Natural Sciences

2 Ravikumar S.

1 Karthik D.

1 Pazhanichamy K.

1 Thamizhiniyzn P.

1 Vijayakumar R.

2 2014

Wyniki wyszukiwania

Influence of lead on growth and nutrient accumulation in Black gram (Vigna mungo L.)

A proteomics approach to identify the differential protein level in cardiac muscle of diabetic rat