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Effects of 2.4 GHz radiofrequency electromagnetic field (RF-EMF) on glioblastoma cells (U-118 MG)

100%

Nowak-Terpilowska A., Gorski R., Marszalek M., Wosinski S., Przesmycki R., Bugaj M., Nowosielski L., Baranowski M., Zeyland J.

Annals of Agricultural and Environmental Medicine

2023

tom 30

nr 4

Synthesis and biological activity of Na-[4-[N-[[3,4-dihydro-2-methyl-4-oxo-6-quinazolinyl]methyl]-N-propargylamino]phenylacetyl]-L-glutamic acid

100%

Kusakiewicz-Dawid A., Bugaj M., Dzik J. M., Golos B., Winska P., Pawelczak K., Rzeszotarska B., Rode W.

Acta Biochimica Polonica

2002

tom 49

nr 1

2-Deamino-2-methyl-N10-propargyl-5,8-dideazafolic acid (ICI 198583) is a potent inhibitor of thymidylate synthase. Its analogue, Nα-[4-[N-[(3,4-dihydro 2-methyl-4 -oxo- 6-quinazolinyl)methyl]-N-propargylamino]phenylacetyl]-L-glutamic acid, containing p-aminophenylacetic acid residue substituting p-aminobenzoic acid residue, was synthesized. The new analogue exhibited a moderately potent thymidylate synthase inhibition, of linear mixed type vs. the cofactor, N5,10 -methylenetetrahydrofolate. The K value of 0.34 uM, determined with a purified recombinant rat hepatoma enzyme, was about 30-fold higher than that reported for inhibition of thymidylate synthase from mouse leukemia L1210 cells by ICI 198583 (Hughes et al., 1990, J. Med. Chem. 33, 3060). Growth of mouse leukemia L5178Y cells was inhibited by the analogue (IC50 = 1.26 mM) 180-fold weaker than by ICI 198583 (IC50 = 6.9 uM).

Ograniczanie wyników

1 Acta Biochimica Polonica

1 Annals of Agricultural and Environmental Medicine

2 Bugaj M.

1 Baranowski M.

1 Dzik J. M.

1 Golos B.

1 Gorski R.

1 Kusakiewicz-Dawid A.

1 Marszalek M.

1 Nowak-Terpilowska A.

1 Nowosielski L.

1 Pawelczak K.

1 Przesmycki R.

1 Rode W.

1 Rzeszotarska B.

1 Winska P.

1 Wosinski S.

1 Zeyland J.

1 2023

1 2002

Wyniki wyszukiwania

Effects of 2.4 GHz radiofrequency electromagnetic field (RF-EMF) on glioblastoma cells (U-118 MG)

Synthesis and biological activity of Na-[4-[N-[[3,4-dihydro-2-methyl-4-oxo-6-quinazolinyl]methyl]-N-propargylamino]phenylacetyl]-L-glutamic acid