The investigations were carried out in one farm during 3 years. Clinical mastitis was treated with the following drugs: 1) Pathozone (55 quarters), 2) Nafpenzal MC (69 quarters), 3) Vetimast (24 quarters), 4) Masticort PS (32 quarters), 5) Syntarpen (78 quarters), 6) a water solution of procainic penicillin (2 min iu) with 1,0 g of streptomycin in 100 ml of distilled water (311 quarters), 7) a water solution of 1,2 ml iu of procainic penicillin (270 quarters), 8) a water solution of streptomycin 1,0 g (16 quarters), 9) a water solution of ampicillin 0,5 g (11 guarters), 10) penicillin procainic (600 000 iu) with acetylosalicylic acid (200 mg) in a 5.0% glucose solution (105 quarters), 11) penicillin (600 000 iu) with chlormethine (0,2 mg) in a 5,0% glucose solution (157 quarters), 12) oxytetracyline (1,0 g) with acetylosalicylic acid (200 mg) in a 5,0% glucose solution (79 quarters), 13) oxytetracyline (1,0 g) with chlormethine (0,2 mg) in a 5,0% glucose solution (68 quarters), 14) neomycin (0,5 g) with acetylosalicylic acid (200 mg) in a 5,0% glucose solution (36 quarters), 15) erytromycin (0,6 g) with chlormethine (0,2 mg) (13 quarters). Pathozone and combinations of antibiotics with acetylosalicylic acid, chlormethine and glucose were intramammary infused only once. Other drugs were applied three times every 24 hr. The effect of therapy established on clinical examinations, bacteriological tests and cell counts in milk was evaluated on the 14th day after treatment. The percentage of cured quarters was as follows: 1 — 65,5%, 2 — 78,3%, 3 — 50%, 4 — 62,2%, 5 — 64,1%, 6 — 66,6%, 7 — 65,9%, 8 — 62,5%, 9 — 72,7%, 10 — 71,4%, 11 — 66,9%, 12 — 79,7%, 13 — 77,9%, 14 — 72,2%, 15 — 69,3%. Quarters treated with combinations of antibiotics with acetylosalicylic acid or chlormethine once were reinfected during the 3-month period half as often as those treated with other drugs.
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