Wyniki wyszukiwania

1

Hospital staff and smoking habits: do we need modification of smoking behavior in Polish hospitals?

100%

Cofta S., Staszewski R.

Journal of Physiology and Pharmacology. Supplement

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2008

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tom 59

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nr 6

191-199

2

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Analysis of serum copper and zinc concentration among excess body mass persons due to their age

81%

Dziegielewska S., Wysocka E., Cofta S., Torlinski L.

Journal of Elementology

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2011

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tom 16

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nr 1

Metabolic alterations in physiological aging may depend on oxidative-antioxidative balance and biomineral status. The aim was to analyze concentrations of serum copper (Cu) and zinc (Zn) among excess body mass persons due to their age. Material: 72 healthy Caucasians, divided into 3 groups: AGE1, AGE2, AGE3 (30-45, 46-60, 61-75 years old respectively), with body mass index (BMI) ≥25 kg m–2 were qualified for oral glucose tolerance test (OGTT) and fasting (G0') and 2-hours (G120') glycemia were determined (enzymatically). Type 2 diabetes mellitus was excluded. Concentration of serum Cu and Zn (AAS), insulin (ELISA) and plasma lipids: total cholesterol, high density lipoproteins cholesterol, triacyloglyceroles (enzymatically) were measured in fasting samples. Low density lipoproteins cholesterol was obtained using Friedewald formula. Insulin Resistance ratios and Cu/Zn ratio were calculated. Results: No differences concerning BMI, waist, diastolic blood pressure, lipids and insulin concentrations and insulin resistance ratios were observed. Increasing G0’, G120' and systolic blood pressure from group 1 to 3 (p=0.01, p=0.01, p=0.04 respectively) were found. AGE2 group had the lowest Zn concentration 10.67±3.37 μmol dm–3, (p=0.002) and the highest Cu/Zn ratio 1.73±0.64 (p=0.0003). We calculated negative correlations Zn and SBP (R=-0.45, p=0.04), Zn and DBP (R=-0.46, p=0.04), Zn and G 120’ (R=-0.45, p=0.03) in the oldest group. Conclusions: Different zinc concentration while aging may occur, and may imply different metabolic usage of the biominerals, especially in obese patients otherwise healthy subjects.

3

Analiza stezen cynku i miedzi w surowicy osob ze zwiekszona masa ciala w zaleznosci od wieku

81%

Dziegielewska S., Wysocka E., Cofta S., Torlinski L.

Journal of Elementology

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2010

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tom 15

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nr 3 Suppl.

26-27

4

Biological status of adult patients with cystic fibrosis

71%

Kosinska M., Szwed A., Cieslik J., Gozdzik J., Cofta S.

Journal of Physiology and Pharmacology. Supplement

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2008

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tom 59

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nr 6

341-348

5

61%

Lisowska A., Pogorzelski A., Oracz G., Skorupa W., Cofta S., Socha J., Walkowiak J.

Acta Scientiarum Polonorum. Technologia Alimentaria

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2010

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tom 09

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nr 4

477-483

Background. Available data suggests that small intestine bacterial overgrowth (SIBO) may frequently occur in cystic fibrosis (CF) subjects. SIBO may result in synthesis of enterotoxic and unabsorbable metabolites which may cause mucosal damage and - additionally - interfere with digestion and absorption. Such a relationship was documented in CF mouse model. Therefore, in the present study we aimed to assess the influence of bacterial overgrowth in small intestine in CF patients on lipid digestion and absorption. Material and methods. The study Comprised 60 pancreatic insufficient CF patients, 30 children and 30 adults. Ali enrolled CF subjects were tested for the presence of SIBO using hydrogen/methane breath test with glucose loading. According to the obtained results CF patients were divided into SIBO positive and negative subgroups. Subsequently, 13C-labelled mixed triglyceride breath test was performed to assess lipid digestion and absorption. Cumulative percentage dose recovery (cPDR) was considered to reflect digestion and absorption of lipids. Results. SIBO was detected in 12 (40.0%) children and 11 (36.7%) adults with CF. The cPDR did not differ between SIBO positive and negative subgroups, neither when assessed separately for children (mean ±SEM: 5.5 ±0.8 vs. 7.4 ±1.0%) and adults (4.9 ±0.8 vs. 7.1 ±0.7%) nor for the entire studied population. Conclusions. Small intestine bacterial overgrowth does not seem to play a key role in lipid digestion and absorption in cystic fibrosis patients.

11

Antibiotic therapy and fat digestion and absorption in cystic fibrosis

51%

Lisowska A., Pogorzelski A., Oracz G., Skorupa W., Cofta S., Szydlowski J., Socha J., Walkowiak J.

Acta Biochimica Polonica

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2011

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tom 58

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nr 3

Antibiotic therapy in the cystic fibrosis (CF) mouse model has been shown to result in reduced bacterial load of the intestine and significant body mass gain. The effect was suggested to be linked to the improvement of intestinal digestion and absorption. Therefore, we aimed to assess the influence of routinely applied antibiotic therapy in CF patients on fat assimilation. Twenty-four CF patients aged 6 to 30 years entered the study. Inclusion criteria comprised confirmed exocrine pancreatic insufficiency and bronchopulmonary exacerbation demanding antibiotic therapy. Exclusion criteria comprised: antibiotic therapy six weeks prior to the test, liver cirrhosis, diabetes mellitus, oxygen dependency, the use of systemic corticosteroids. In all enrolled CF subjects, 13C-labelled mixed triglyceride breath test (13C MTG-BT) was performed to assess lipid digestion and absorption, before and after antibiotic therapy. Sixteen subjects were treated intravenously with ceftazidime and amikacin, eight patients orally with ciprofloxacin. Cumulative percentage dose recovery (CPDR) was considered to reflect digestion and absorption of lipids. The values are expressed as means (medians). The values of CPDR before and after antibiotic therapy did not differ in the whole studied group [4.6(3.3) % vs. 5.7(5.3) %, p = 0.100] as well as in the subgroup receiving them intravenously [4.6(3.2) % vs. 5.7(5.3) %, p = 0.327] or in that with oral drug administration [4.6(3.4) % vs. 5.7(5.4) %, p = 0.167]. In conclusion, antibiotic therapy applied routinely in the course of pulmonary exacerbation in CF patients does not seem to result in an improvement of fat digestion and absorption.

12

Vitamin A status and its determinants in patients with cystic fibrosis

51%

Sapiejka E., Krzyzanowska P., Walkowiak D., Wenska-Chyzy, Szczepanik M., Cofta S., Pogorzelski A., Skorupa W., Walkowiak J.

Acta Scientiarum Polonorum. Technologia Alimentaria

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2017

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tom 16

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nr 3

Ograniczanie wyników

Hospital staff and smoking habits: do we need modification of smoking behavior in Polish hospitals?

Analysis of serum copper and zinc concentration among excess body mass persons due to their age

Analiza stezen cynku i miedzi w surowicy osob ze zwiekszona masa ciala w zaleznosci od wieku

Biological status of adult patients with cystic fibrosis

Periodontal status and subgingival biofilms in cystic fibrosis adults

Relationship between nutritional status and pulmonary function in adult cystic fibrosis patients

Oxidative stress markers in the blood of persons with different stages of obstructive sleep apnea syndrome

The impact of the sleep apnea syndrome on oxidant-antioxidant balance in the blood of overweight and obese patients

Correlation between the stage of cystic fibrosis and the level of morphological changes in adult patients

Small intestine bacterial overgrowth and fat digestion and absorption in cystic fibrosis patients

Antibiotic therapy and fat digestion and absorption in cystic fibrosis

Vitamin A status and its determinants in patients with cystic fibrosis