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Tritolylporphyrin dimer as a new potent hydrophobic sensitizer for photodynamic therapy of melanoma

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Drzewiecka A., Urbanska K., Matuszak Z., Pineiro M., Arnaut L. G., Habdas J., Ratuszna A., Stochel G.

Acta Biochimica Polonica

2001

tom 48

nr 1

We report the synthesis, photochemical and photophysical properties and preliminary studies on biological effect of a new tritolylporphyrin dimer (T-D). Absorption and emission properties of T-D suggest its possible use in photodynamic therapy. T-D is capable of singlet oxygen production with 0.8 quantum yield. It also has a high photostability. The photodynamic properties of the dimer were examined following the growth of SKMEL 188 (human melanoma) cells irradiated with red light (cut off < 630 nm). The surviving fraction of the cells decreased about 3-fold (us. non-irradiated cells) for an 81 J/cm dose. Our results suggest that tritolylporphyrine dimer T-D may be an interesting hydrophobic sensitizer for photodynamic therapy.

Ograniczanie wyników

1 Acta Biochimica Polonica

1 Arnaut L. G.

1 Drzewiecka A.

1 Habdas J.

1 Matuszak Z.

1 Pineiro M.

1 Ratuszna A.

1 Stochel G.

1 Urbanska K.

1 2001

Wyniki wyszukiwania

Tritolylporphyrin dimer as a new potent hydrophobic sensitizer for photodynamic therapy of melanoma