Wyniki wyszukiwania

1

Distinction between voluntary cough sound and speech in volunteers by spectral and complexity analysis

100%

Martinek J., Tatar M., Javorka M.

Journal of Physiology and Pharmacology. Supplement

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2008

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tom 59

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nr 6

433-440

2

Wavelet analysis of voluntary cough sound in patients with respiratory diseases

100%

Knocikova J., Korpas J., Vrabec M., Javorka M.

Journal of Physiology and Pharmacology. Supplement

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2008

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tom 59

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nr 6

331-340

3

Reliability of the capsaicin cough reflex sensitivity test in healthy children

100%

Verechova S., Plevkova J., Javorka M., Hanacek J.

Journal of Physiology and Pharmacology. Supplement

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2006

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tom 57

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nr 4

365-373

Testing cough reflex sensitivity (CRS) in children requires suitable methodology. A CRS test performed under control of inspiratory flow rate (IFR) shows excellent reliability in children, but it is difficult to perform, especially in younger children. The aim of the present study was to find whether the capsaicin CRS test performed without direct control of constant IFR in healthy children is reliable enough for practical use. The CRS test was performed in 27 healthy children, aged 7-17 yr three times within 8 days. Cough was induced by inhalation of capsaicin aerosol in doubling concentrations (0.61-1250 µmol/l) for 400 ms each. CRS was defined as the lowest capsaicin concentration that evoked 2 or more coughs (C2). Although the intraclass correlation coefficient values showed good to excellent reliability of this test, the within-subject standard deviation values revealed lower reliability of this method compared to the CRS test performed under control of IFR. From the results obtained it is reasonable to conclude that the method using uncontrolled IFR in CRS testing provides acceptable precision only when a bigger sample size is used or more tests are performed. Good to excellent reliability of this method was found in children with higher values of C2 and in those aged 13-17 yr.

4

Effects of hypovolemia on hypercapnic ventilatory response in experimental hyperthermia

88%

Zila I., Brozmanova A., Javorka M., Calkovska A., Javorka K.

Journal of Physiology and Pharmacology. Supplement

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2007

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tom 58

|

nr 5

5

Oral N-acetylcysteine reverses hyperoxia-related cough suppression in guinea pigs

76%

Brozmanova M., Plevkova J., Bartos V., Plank L., Javorka M., Masar J., Tatar M.

Journal of Physiology and Pharmacology. Supplement

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2007

|

tom 58

|

nr 5

6

The interaction of dietary antioxidant vitamins and oxidative stress on cough reflex in guinea-pigs after long term oxygen therapy

76%

Brozmanova M., Plevkova J., Bartos V., Plank L., Javorka M., Tatar M.

Journal of Physiology and Pharmacology. Supplement

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2006

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tom 57

|

nr 4

45-54

Inhalation of high concentration of oxygen produces oxidative stress in men and experimental animals. Our previous experiments showed that the cough reflex is suppressed in guinea pigs after exposure to 100% O2 for 60 hours. The aim of this study was to determine the effects of dietary antioxidant supplementation with vitamins C and E on hyperoxia-induced oxidative stress in airway and lung tissues directed on cough reflex. The experimental group (T-H, n=8) was pretreated with vitamins C (500 mg/kg) and E (300 mg/kg) for 4 weeks and subsequently exposed to 100% O2 for 60 hours. Hyperoxic group (H, n=8) received saline instead of antioxidants and then inhaled 100% O2 for 60 hours. Cough was induced by inhalation of citric acid aerosol in gradually increased concentration (0.05-1.6 M) at the end of antioxidant therapy and then at the end of exposure to 100% O2. Cough was also induced by mechanical stimulation of laryngopharyngeal (LPh) and tracheobronchial (TBr) region in anaesthetized animals just 1 hour after the end of oxygen exposure. Our results showed a tendency to a decrease in citric acid-induced cough in hyperoxic animals and an increase in animals with antioxidant therapy after hyperoxia. Antioxidant therapy significantly unblocked hyperoxia-induced down-regulation of cough (P=0.004). Significant changes also were obtained from mechanically-induced TBr cough [2.5(1-4) vs. 1.0(1-2); P<0.01] between the experimental and hyperoxic (control) animals. In conclusion, our results indicate a protective effect of antioxidant supplementation on oxidant-mediated cough depression.

7

Influence of chest gamma-irradiation on cough response in awake guinea pigs

76%

Brozmanova M., Javorkova N., Hajtmanova E., Zamecnik L., Javorka M., Hanacek J., Tatar M.

Journal of Physiology and Pharmacology. Supplement

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2007

|

tom 58

|

nr 5

8

Cardio-respiratory interaction and autonomic dysfunction in obesity

64%

Tonhajzerova I., Javorka M., Trunkvalterova Z., Chroma O., Javorkova J., Lazarova Z., Ciljakova M., Javorka K.

Journal of Physiology and Pharmacology. Supplement

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2008

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tom 59

|

nr 6

709-718

9

Effects of thorax irradiation on citric acid-induced cough in guinea pigs

64%

Javorkova N., Brozmanova M., Hajtmanova E., Zamecnik L., Bartos V., Plank L., Javorka M., Hanacek J., Tatar M.

Journal of Physiology and Pharmacology. Supplement

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2006

|

tom 57

|

nr 4

149-156

Thoracic irradiation may cause an acute lymphocytic alveolitis or hypersensitivity pneumonitis. It is well known that cough reflex is sensitized by a number of inflammatory mediators. The purpose of the present study was to investigate the effect of the thoracic irradiation on the cough response in awake guinea pigs. Guinea pigs (Trik strain) were exposed to sham irradiation (n=16), a single irradiation dose of 10 Gy (n=12), and a fractionated irradiation dose (in five fractions) of 15 Gy (n=12) delivered to the thorax. Cough was induced by citric acid aerosol inhalation in gradually increasing concentrations (0.05-1.6 M) during the first week after thoracic irradiation. The cough response was expressed as a total number of coughs induced during all citric acid challenges. Irradiated animals with single dose of 10 Gy exhibited a time- dependent significant increase of citric acid-induced cough in the 6th day after irradiation compared with control animals (P=0.005), whereas cough was not altered significantly in irradiated animals with fractionated dose of 15 Gy. This study demonstrates that the increased cough response may be a determinant of the functional changes of airway nerve-endings mediating cough in the early phase after thoracic irradiation.

Ograniczanie wyników

Distinction between voluntary cough sound and speech in volunteers by spectral and complexity analysis

Wavelet analysis of voluntary cough sound in patients with respiratory diseases

Reliability of the capsaicin cough reflex sensitivity test in healthy children

Effects of hypovolemia on hypercapnic ventilatory response in experimental hyperthermia

Oral N-acetylcysteine reverses hyperoxia-related cough suppression in guinea pigs

The interaction of dietary antioxidant vitamins and oxidative stress on cough reflex in guinea-pigs after long term oxygen therapy

Influence of chest gamma-irradiation on cough response in awake guinea pigs

Cardio-respiratory interaction and autonomic dysfunction in obesity

Effects of thorax irradiation on citric acid-induced cough in guinea pigs