Wyniki wyszukiwania

1

Epidemiological evidence of the effects of environmental pollution on male reproductive health in an electronic waste-recycling Town

100%

Du H., Yu M., Sun J., Song G., Li Y.

Polish Journal of Environmental Studies

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2016

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tom 25

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nr 4

In recent years have seen increasing evidence linking occupational and environmental exposure to toxic pollutants with human male reproductive disorders. The aim of this study was to collect epidemiological information on male reproductive health to explore the effects of electronic waste (e-waste) environmental pollution on male genital health in Wenling, one of the world’s biggest e-waste recycling centers. We collected clinic information from 2001 to 2012 in Wenling covering male reproductive diseases, including prostatitis, epididymitis, orchitis, urinary tract infections, cystospermitis, impotence, condyloma accuminatum, syphilis, gonorrhea, varicocele, genital herpes, prostatic carcinoma, etc. The morbidity of male reproductive diseases in Wenling was higher than in the control area – especially those diseases that could be influenced by environmental factors. Male reproductive health may be threatened by e-waste pollution in Wenling, and this could influence local population diathesis.

2

17beta-Estradiol promotes cell proliferation in rat osteoarthritis model chondrocytes via PI3K/Akt pathway

86%

Huang J., Xia C., Zheng X., Yi T., Wang X., Song G., Zhang B.

Cellular and Molecular Biology Letters

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2011

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tom 16

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nr 4

Osteoarthritis (OA) is the most common cause of musculoskeletal pain and disability. The importance of chondrocytes in the pathogenesis of OA is unequivocal. 17β-estradiol (E2) has a potential protective effect against OA. However, the mechanism of E2 in OA chondrocytes remains unclear. In this study, we investigated the regulative effect of E2 on cell growth and the relationship between E2 and the PI3K/Akt pathway in rat OA model chondrocytes (pretreated with interleukin-1β). We found that E2 induced chondrocyte proliferation, and increased the expression level of Akt simultaneously, especially the expression level of P-Akt. Furthermore, the inhibition of P-Akt could block chondrocyte proliferation induced by E2. These results suggest that PI3K/Akt activation induced by E2 may be an important factor in the mechanism of E2 in cell proliferation in rat OA model chondrocytes, and help further understanding the role of E2 in OA progression.

3

Metastasis of human gastric adenocarcinoma partly depends on phosphoinositide-specific phospholipase gamma1 expression

72%

Zhuang L., Zhang B., Zeng G., Dai L., Qian H., Hu T., Song G., Zhang B., Xia C.

Folia Histochemica et Cytobiologica

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2014

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tom 52

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nr 3

4

Toxic effects of anatase titanium dioxide nanoparticles on spermatogenesis and testicles in male mice

72%

Song G., Lin L., Liu L., Wang K., Ding Y., Niu Q., Mu L., Wang H., Shen H., Guo S.

Polish Journal of Environmental Studies

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2017

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tom 26

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nr 6

Anatase TiO₂ nanoparticles (NPs) are widely used in food products, capsules, toothpaste, and so on, so the kinds of NPs directly get in touch with human bodies. The potential effect of this kind of material on reproduction must be considered with the increase in infertility. Sixty ICR male mice were intragastrically treated with dosages of 0, 10, 50, and 100 mg kg⁻¹ body weight (BW) anatase TiO₂ NPs to investigate the male reproductive toxicity of the NPs. Sperm quality, morphological changes in mice testes, and oxidative damage indexes were investigated in this study. Results showed that anatase TiO₂ NPs could lead to sperm malformation and increased rate of sperm cell micronucleus. These NPs also reduced the germ cell number and led to spherospermia, interstitial glands vacuole, malalignment, and vacuolization of spermatogenic cells in mice testes. Testicular cells accumulated reactive oxygen species when the mice were intragastrically administrated with TiO₂ NPs. Superoxide dismutase activity decreased, and the malondialdehyde content increased in the TiO₂ NP-treated groups. Anatase TiO₂ NPs exerted potential toxic effects on male reproduction, so the widespread application of this kind of NP in food products needs to be regulated.

Ograniczanie wyników

2 Polish Journal of Environmental Studies

1 Cellular and Molecular Biology Letters

1 Folia Histochemica et Cytobiologica

4 Song G.

2 Xia C.

2 Zhang B.

1 Dai L.

1 Ding Y.

1 Du H.

1 Guo S.

1 Hu T.

1 Huang J.

1 Li Y.

1 Lin L.

1 Liu L.

1 Mu L.

1 Niu Q.

1 Qian H.

1 Shen H.

1 Sun J.

1 Wang H.

1 Wang K.

1 Wang X.

1 Yi T.

1 Yu M.

1 Zeng G.

1 Zheng X.

1 Zhuang L.

1 2017

1 2016

1 2014

1 2011

Epidemiological evidence of the effects of environmental pollution on male reproductive health in an electronic waste-recycling Town

17beta-Estradiol promotes cell proliferation in rat osteoarthritis model chondrocytes via PI3K/Akt pathway

Metastasis of human gastric adenocarcinoma partly depends on phosphoinositide-specific phospholipase gamma1 expression

Toxic effects of anatase titanium dioxide nanoparticles on spermatogenesis and testicles in male mice