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Overexpression of human osteopontin increases cell proliferation and migration in human embryo kidney-293 cells

100%

Liu Y. J., Zhang D.-Q., Sui X.-M., Tian W.

Cellular and Molecular Biology Letters

2009

tom 14

nr 4

670-678

Malignant tumors are characterized by dysregulated cell growth and the metastasis of secondary tumors. Numerous studies have documented that osteopontin (OPN) plays a key role in regulating tumor progression and metastasis. Here, we show that the overexpression of OPN in human embryo kidney-293 cells significantly increases both the level of cell proliferation, by provoking the G1/S transition, and the level of cell migration in vitro. These findings suggest that augmented OPN contributes to cell growth and motility. Inhibiting OPN or the pathway it stimulates may therefore represent a novel approach for the treatment of primary tumors and associated metastases.

The inhibition of in vivo tumorigenesis of osteosarcoma [OS]-732 cells by antisense human osteopontin RNA

64%

Liu S. J., Zhang D.-Q., Sui X.-M., Zhang L., Cai Z.-W., Sun L.-Q., Liu Y.-J., Xue Y., Hu G.-F.

Cellular and Molecular Biology Letters

2008

tom 13

nr 1

11-19

Osteopontin (OPN) is a secreted, non-collagenous, sialic acid-rich protein which functions by mediating cell-matrix interactions and cellular signaling via binding with integrins and CD44 receptors. An increasing number of studies have shown that OPN plays an important role in controlling cancer progression and metastasis. OPN was found to be expressed in many human cancer types, and in some cases, its over-expression was shown to be directly associated with poor patient prognosis. In vitro cancer cell line and animal model studies have clearly indicated that OPN can function in regulating the cell signaling that ultimately controls the oncogenic potential of various cancers. Previous studies in our laboratory demonstrated that OPN is highly expressed in human osteosarcoma (OS) cell line OS-732. In this study, we successfully reduced the tumorigenecity of OS-732 cells xenotransplanted into nude mice, using the antisense human OPN (hOPN) RNA expression vector.

Ograniczanie wyników

2 Cellular and Molecular Biology Letters

2 Sui X.-M.

2 Zhang D.-Q.

1 Cai Z.-W.

1 Hu G.-F.

1 Liu S. J.

1 Liu Y. J.

1 Liu Y.-J.

1 Sun L.-Q.

1 Tian W.

1 Xue Y.

1 Zhang L.

1 2009

1 2008

Wyniki wyszukiwania

Overexpression of human osteopontin increases cell proliferation and migration in human embryo kidney-293 cells

The inhibition of in vivo tumorigenesis of osteosarcoma [OS]-732 cells by antisense human osteopontin RNA