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Modern human origins and prehistoric demography of Europe in light of the present-day genetic diversity

100%

Zietkiewicz E.

Journal of Applied Genetics

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2001

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tom 42

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nr 4

2

Komórkowe antygeny rybonukleoproteinowe

63%

Zietkiewicz E., Slomski R.

Postępy Biochemii

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1985

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tom 31

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nr 2

3

Zastosowanie liposomów w przenoszeniu substancji o znaczeniu biologicznym do komórek

63%

Zietkiewicz E., Slomski R.

Postępy Biochemii

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1984

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tom 30

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nr 1-2

4

Zastosowanie technik rekombinacji DNA w genetyce człowieka

63%

Slomski R., Zietkiewicz E.

Postępy Biochemii

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1987

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tom 33

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nr 4

5

Transcriptome variation in human populations and its potential application in forensics

63%

Daca-Roszak P., Zietkiewicz E.

Journal of Applied Genetics

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2019

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tom 60

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nr 3-4

6

Cytogenetic perspective of ageing and longevity in men and women

51%

Zietkiewicz E., Wojda A., Witt M.

Journal of Applied Genetics

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2009

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tom 50

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nr 3

261-273

Analysis of relationships between the ageing cell phenotype and the age of cell donors is one of the ways towards understanding the link between cellular and organismal ageing. Cytogenetically, ageing is associated with a number of gross cellular changes, including altered size and morphology, genomic instability, and changes in expression and proliferation. Genomic instability can be easily assessed by analyzing the level of cytogenetic aberrations. In this review, we focus on the differences in the level and profile of cytogenetic aberrations observed in donors of different age and gender. Centenarians are a small fraction of the population at the extreme of human longevity. Their inclusion in such studies may shed light on one of the basic questions: whether genome stability is better maintained in successfully aged individuals compared to the rest of the population. At the same time, comparing the profile of age-related amount of chromosomal aberrations in men and women may help explaining the commonly observed gender differences in longevity.

7

In vitro culturing of ciliary respiratory cells - a model for studies of genetic diseases

51%

Bukowy Z., Zietkiewicz E., Witt M.

Journal of Applied Genetics

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2011

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tom 52

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nr 1

Primary ciliary dyskinesia (PCD) is a rare genetic disorder caused by the impaired functioning of ciliated cells. Its diagnosis is based on the analysis of the structure and functioning of cilia present in the respiratory epithelium (RE) of the patient. Abnormalities of cilia caused by hereditary mutations closely resemble and often overlap with defects induced by the environmental factors. As a result, proper diagnosis of PCD is difficult and may require repeated sampling of patients’ tissue, which is not always possible. The culturing of differentiated cells and tissues derived from the human RE seems to be the best way to diagnose PCD, to study genotype–phenotype relations of genes involved in ciliary dysfunction, as well as other aspects related to the functioning of the RE. In this review, different methods of culturing differentiated cells and tissues derived from the human RE, along with their potential and limitations, are summarized. Several considerations with respect to the factors influencing the process of in vitro differentiation (cell-to-cell interactions, medium composition, cell-support substrate) are also discussed.

8

Differential expression of tumor-associanted antigens on ASL-I parential and ASL-1 X LM (TK-) hybrid cell lines

51%

Slomski R., Wang D.-G., Zietkiewicz E., Cohen E. P.

Genetica Polonica

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1985

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tom 26

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nr 1

9

Identification of U1A snRNA genes in human lymphocytes

51%

Jaruzelska J., Zietkiewicz E., Slomski R.

Genetica Polonica

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1985

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tom 26

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nr 1

10

Genotyping intragenic neutral markers allows genetic homogenization of primary ciliary dyskinesia (PCD) families before screening for causative mutations in the DNAH5 gene

45%

Tomaszewska A., Voelkel K., Rutkiewicz E., Witt M., Zietkiewicz E.

Acta Biochimica Polonica

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2006

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tom 53

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nr Supplement 1

11

Immunoprecipitation of nuclear antigens using antibodies from patients with various autoimmune diseases

45%

Zietkiewicz E., Prokop J., Jaruzelska J., Bowszyc J., Slomski R.

Genetica Polonica

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1985

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tom 26

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nr 1

12

Carrier status for 3 most frequent CFTR mutations in Polish PCD-KS patients: lack of association with the primary ciliary dyskinesia phenotype

45%

Skrzypczak U., Rutkiewicz E., Pogorzelski A., Witt M., Zietkiewicz E.

Journal of Applied Genetics

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2007

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tom 48

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nr 1

85-88

We screened a large group of primary ciliary dyskinesia/Kartagener syndrome (PCD/KS) patients and their siblings (148 patients from 126 unrelated families) for the presence of the CFTR mutations that are most frequently found in the Polish population: the severe F508del and 2,3del21kb, and the mild 3849+l0kbC > T. No statistically significant increase in the frequency of these mutations was found in the studied group, as compared with the general population. This is consistent with an earlier observation in another population and indicates that the status of being a carrier of any of these CFTR mutations should not be considered as an important risk factor in PCD/KS pathogenesis.

13

Genetic background primary ciliary dyskinesia and Kartagenery syndrome (PCD/KS) in Polish patients-analysis of mutations in the DNAH5 gene and search for possible association with the major mutation in the CFTR gene

39%

Srzypczak U., Voelkel K., Modrzynska K., Rutkiewicz E., Witt M., Zietkiewicz E.

Acta Biochimica Polonica

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2006

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tom 53

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nr Supplement 1

14

Neutral haplotype diversity in the CFTR gene in healthy Polish population and in cystic fibrosis patients carrying four most frequent CF mutations

39%

Voelkel K., Joskowiak A., Nawracala M., Rutkiewicz E., Skrzypczak U., Witt M., Zietkiewicz E.

Acta Biochimica Polonica

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2006

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tom 53

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nr Supplement 1

15

RPGR mutation in the patient with overlapping X-linked retinitis pigmentosa and primary ciliary dyskinesia symptoms apparently disrupts transport of the inner dynein arm component into the cilium

39%

Zietkiewicz E., Geremek M., Omran H., Amselem S., Pogorzelski A., Biczysko W., Witt M.

Acta Biochimica Polonica

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2006

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tom 53

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nr Supplement 1

Ograniczanie wyników

Modern human origins and prehistoric demography of Europe in light of the present-day genetic diversity

Komórkowe antygeny rybonukleoproteinowe

Zastosowanie liposomów w przenoszeniu substancji o znaczeniu biologicznym do komórek

Zastosowanie technik rekombinacji DNA w genetyce człowieka

Transcriptome variation in human populations and its potential application in forensics

Cytogenetic perspective of ageing and longevity in men and women

In vitro culturing of ciliary respiratory cells - a model for studies of genetic diseases

Differential expression of tumor-associanted antigens on ASL-I parential and ASL-1 X LM (TK-) hybrid cell lines

Identification of U1A snRNA genes in human lymphocytes

Genotyping intragenic neutral markers allows genetic homogenization of primary ciliary dyskinesia (PCD) families before screening for causative mutations in the DNAH5 gene

Immunoprecipitation of nuclear antigens using antibodies from patients with various autoimmune diseases

Carrier status for 3 most frequent CFTR mutations in Polish PCD-KS patients: lack of association with the primary ciliary dyskinesia phenotype

Genetic background primary ciliary dyskinesia and Kartagenery syndrome (PCD/KS) in Polish patients-analysis of mutations in the DNAH5 gene and search for possible association with the major mutation in the CFTR gene

Neutral haplotype diversity in the CFTR gene in healthy Polish population and in cystic fibrosis patients carrying four most frequent CF mutations

RPGR mutation in the patient with overlapping X-linked retinitis pigmentosa and primary ciliary dyskinesia symptoms apparently disrupts transport of the inner dynein arm component into the cilium