Wyniki wyszukiwania

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Platelet and intestinal 5-HT2A receptor mRNA in autistic spectrum disorders - results of a pilot study

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Kazek B., Huzarska M., Grzybowska-Chlebowczyk U., Kajor M., Ciupinska-Kajor M., Wos H., Marszal E.

Acta Neurobiologiae Experimentalis

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2010

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tom 70

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nr 2

The etiology and pathogenesis of autistic spectrum disorders (ASD) are still unknown. Platelet hyperserotonemia has been detected in 25-60% of autistic children. Higher incidence of gastrointestinal problems in people with autism is observed. The aim was compare the expression of platelet 5-HT2Ar mRNA in autistic and non autistic groups. In a subgroup of patients with gastrointestinal problems an upper gastrointestinal tract endoscopy was performed and additionally the expression of 5-HT2A receptor mRNA in the duodenum was assessed. The examination was conducted in 79 children - 51 with ASD and 28 without autistic traits. Statistically significant differences between the study and control groups were proven in gastrointestinal problems. The analyses reveal a significantly higher level of 5-HT2Ar mRNA in platelets of the study group patients, which could suggest serotonin system dysregulation.

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Children's allergic diseases and microbial contamination of indoor air - a case report

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Kasznia-Kocot J., Lis D. O., Kordys-Darmolinska B., Grzybowska-Chlebowczyk U., Wos H., Gorny R. L.

Annals of Agricultural and Environmental Medicine

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2007

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tom 14

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nr 1

The assessment of exposure to bioaerosols in damp houses of two children who suffered from perennial rhinitis and asthma was performed. The paper presents an approach to the complex (i.e., medical and environmental) treatment of allergic diseases.

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Serotype-specific pneumococcal status prior to PCV 13 administration in children and adolescents with inflammatory bowel disease

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Banaszkiewicz A., Targonska B., Kowalska-Duplaga K., Karolewska-Bochenek K., Sieczkowska A., Gawronska A., Grzybowska-Chlebowczyk U., Krzesiek E., Lazowska-Przeorek I., Kotowska M., Sienkiewicz E., Walkowiak J., Gregorek H., Radzikowski A., Albrecht P.

Polish Journal of Microbiology

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2016

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tom 65

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nr 1

The aim of this study was to evaluate the serotype-specific pneumococcal status of children and adolescents with inflammatory bowel disease (IBD) who were naïve to pneumococcal vaccination before administering the 13-valent pneumococcal conjugate vaccine (PCV 13). This was an open, prospective study on children and adolescents aged 5–18 years who had IBD and were naïve to pneumococcal vaccination. A single dose of PCV 13 was administered to each patient. The geometric mean concentrations (GMCs) were measured for all 13 serotypes. A total of 122 subjects completed the study. Prevaccination GMCs ranged from 0.55 μg/ml (serotype 4) to 4.26 μg/ml (serotype 19A). Prior to the administration of PCV 13, high GMCs were detected in older children and adolescents who had IBD and were naïve to pneumococcal vaccination.

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Comparison of fecal pyruvate kinase isoform M2 and calprotectin in assessment of pediatric inflammatory bowel disease severity and activity

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Czub E., Nowak J. K., Szaflarska-Poplawska A., Grzybowska-Chlebowczyk U., Landowski P., Moczko J., Adamczak D., Mankowski P., Banasiewicz T., Plawski A., Walkowiak J.

Acta Biochimica Polonica

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2014

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tom 61

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nr 1

Aims: Accurate assessment of inflammatory bowel disease (IBD) activity is the cornerstone of effective therapy. Fecal M2 isoform of pyruvate kinase (M2-PK) and fecal calprotectin (FC) are noninvasive markers of mucosal inflammation in IBD. The aim of this study was to compare performance of M2-PK and FC in assessment of pediatric ulcerative colitis (UC) and Crohn's disease (CD) severity and activity. Materials and methods: 121 patients with IBD, including 75 with UC and 46 with CD were recruited. Control group consisted of 35 healthy children (HS). Patients were assigned to groups depending on disease severity and activity. M2-PK and calprotectin concentration were determined in stool samples using ELISA. Areas under receiver operating characteristic curves (AUC) for FC and M2-PK with cut-off level at which M2-PK specificity was matching FC specificity were calculated and compared. Results: Performance of M2-PK at identifying patients with IBD, UC and CD among HS was inferior to FC. The differences in AUC were respectively: -0.10 (95% confidence interval [CI] [-0.13-(-0.06)], p<0.0001), -0.14 (95% CI [-0.19-(-0.09)], p<0.0001) and -0.03 (95% CI [-0.05-(-0.001)], p<0.02). M2-PK was inferior to FC in discriminating patients with mild UC from those with HS (AUC difference -0.23, 95% CI [-0.31-(-0.15)], p<0.0001). Conclusions: FC reflects pediatric IBD severity and activity better than M2-PK. This difference is particularly pronounced when identifying patients with mild UC and UC in remission.

Ograniczanie wyników

Platelet and intestinal 5-HT2A receptor mRNA in autistic spectrum disorders - results of a pilot study

Children's allergic diseases and microbial contamination of indoor air - a case report

Serotype-specific pneumococcal status prior to PCV 13 administration in children and adolescents with inflammatory bowel disease

Comparison of fecal pyruvate kinase isoform M2 and calprotectin in assessment of pediatric inflammatory bowel disease severity and activity