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Antioxidant-rich food supplement Lisosan G induces reversion of hepatic steatosis

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Laus M. N., Denoth F., Ciardi M., Giorgetti L., Pucci L., Sacco R., Pastore D., Longo V.

Medycyna Weterynaryjna

2013

tom 69

nr 04

Antioxidant activity (AA) of Lisosan G, a food supplement obtained from wheat grains, was evaluated by using the LOX/RNO, ORAC and TEAC methods. Very high AA was found, associated with a high fraction of freely-extractable phytochemicals expected to be readily absorbed in the small intestine and to exert systemic healthy effects. So, a possible beneficial effect of Lisosan G against non-alcoholic hepatic steatosis induced in mice by 90 days of hyperlipidic diet was studied. Feeding Lisosan G to mice with hepatic steatosis caused rapid reversion of liver disorder: just after 7 days the liver resulted free of steatosis, showing triglyceride content and histological properties similar to control group. Contrarily, the switch of hyperlipidic diet towards a standard diet did not rapidly reverse hepatic steatosis, with a recovery observed only after 30 days. Our results shed a first insight on the therapeutic potential of Lisosan G against the hepatic steatosis disorder in animal species.

Ograniczanie wyników

1 Medycyna Weterynaryjna

1 Ciardi M.

1 Denoth F.

1 Giorgetti L.

1 Laus M. N.

1 Longo V.

1 Pastore D.

1 Pucci L.

1 Sacco R.

1 2013

Wyniki wyszukiwania

Antioxidant-rich food supplement Lisosan G induces reversion of hepatic steatosis