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A new middle Cambrian trilobite with a specialized cephalon from Shandong Province, North China

100%
Sun Z., Zeng H., Zhao F.
Acta Palaeontologica Polonica
|
2020
|
tom 65
|
nr 4
2

Droxinostat sensitizes human colon cancer cells to apoptotic cell death via induction of oxidative stress

100%
Huang Y., Yang W., Zeng H., Hu C.
Cellular and Molecular Biology Letters
|
2018
|
tom 23
Upregulation of histone acetylation plays a critical role in the dysregulation of transcription. It alters the structure of chromatin, which leads to the onset of cancer. Histone deacetylase inhibitors may therefore be a promising way to limit cancer progression. In this study, we examined the effects of droxinostat on the growth of HT-29 colon cancer cells. Our results show that droxinostat effectively inhibited cell growth and colony-forming ability by inducing cellular apoptosis and ROS production in HT-29 cells. Notably, the apoptotic inhibitor Z-VAD-FMK significantly decreased the levels of cellular apoptosis and the antioxidant γ-tocotrienol (GT3) significantly decreased ROS production induced by droxinostat treatment. Z-VAD-FMK and GT3 also partially reversed the negative growth effects of droxinstat on HT-29 cells. GT3 treatment decreased cellular apoptosis and increased colony-forming ability upon droxinostat administration. Z-VAD-FMK treatment also partially decreased droxinostat-induced ROS production. Our findings suggest that the effects of droxinostat on colon cancer cells are mediated by the induction of oxidative stress and apoptotic cell death.
3

Effect of foliar spray of zinc on chloroplast beta-carbonic anhydrase expression and enzyme activity in rice (Oryza sativa L.) leaves

76%
Qiao X., He Y., Wang Z., Li X., Zhang K., Zeng H.
Acta Physiologiae Plantarum
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2014
|
tom 36
|
nr 02
The β-carbonic anhydrase (β-CA) is regarded as a zinc-containing enzyme involved in photosynthesis. Here, the rice plants of cv. N22 were treated with foliar spray at a Zn²⁺ concentration range from 0–35.0 mM during the tillering stage. The β-CA expression in the treated leaves was quantitatively determined by RT-qPCR and gel-based immunoblotting techniques, and its enzyme activity and relative chlorophyll concentration were measured. Results indicated that exogenous zinc could benefit rice plants at the tillering stage, particularly chloroplast β-CA with a fourfold enhancement in gene expression and a 14.6 % increase in its activity by treating the rice leaves with the 7.0-mM Zn²⁺ concentration, thereby promoting photosynthesis by a 19.4 % increase in relative chlorophyll concentration per unit leaf area. Results also showed that the application of Zn²⁺ at a concentration exceeding 7.0 mM could result in leaf senescence, and in some cases leaf hurts with significant inactivation (decreasing by approximately 70 %) of β-CA enzyme. It could be concluded that the application of 7.0-mM Zn²⁺ benefits rice plants at the tillering stage. The β-CA activity was associated with the catalytic microenvironment, thus providing an indicator for physiological response to exogenous zinc in rice.
4

Pollution characteristics of heavy elements in Nanchang, China street dust

76%
Xu X., Zhang H., Xiong X., Zhang H., Zeng H., Yang W.
Polish Journal of Environmental Studies
|
2020
|
tom 29
|
nr 1
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