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1

Is the repair of articular cartilage lesion by costal chondrocyte transplantation donor age-dependent? An experimental study in rabbits

100%
Szeparowicz P., Popko J., Sawicki B., Wolczynski S.
Folia Histochemica et Cytobiologica
|
2006
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tom 44
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nr 3
2

Rabbit articular cartilage defects treated with cultured costal chondrocytes [preliminary report]

88%
Popko J., Szeparowicz P., Sawicki B., Wolczynski S., Wojnar J.
Folia Morphologica
|
2003
|
tom 62
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nr 2
An attempt to repair articular cartilage defects by costal chondrocytes transplantation was made. A full-thickness defect in the rabbit’s femoral patellar groove was artificially made. Cultured costal cartilage chondrocytes were then transplanted into the defects and covered with periosteal flaps. Empty defects were used as the control group. Animals were divided into two groups (five rabbits each). They were examined after four and twelve weeks from the day of transplantation, respectively. The reparative tissue was evaluated by macroscopic and histological examinations. The reparative tissues in defects with transplanted chondrocytes had an hyaline-like cartilage appearance and were firmly attached to the surrounding normal cartilage. No trace of newly formed bone was detected. The reparative tissues found in defects that were left empty had a fibrous character. They were loosely connected to the surrounding cartilage and were more compliant than tissues from transplanted defects. Considering these initial findings, the ease of surgical procedures during the harvesting of the costal cartilage and few interventions into the joint make the costal cartilage a promising source of chondrocytes for transplantation. However, this needs to be confirmed on a larger scale over a longer period of time.
3

Lead, cadmium, copper and zine concentrations in blood and hair of mothers of children with locomotor system malformations

76%
Popko J., Olszewski S., Hukalowicz K., Markiewicz R., Borawska M. H., Szeparowicz P.
Polish Journal of Environmental Studies
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2003
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tom 12
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nr 3
Cadmium, copper and zinc concentrations in the blood and hair of 51 women after delivery of children with locomotor system malformations (Group I) and, as a control, 46 women who gave birth to healthy children (Group II) were different but none of the values were statistically significant. However, lead concentrations in the blood and the hair of women from the Group I (median: 109.63 μg/L and 1.31 μg/g) were notably higher than in Group II (median: 66.45 μg/L and 0.58 μg/g, respectively). Maternal lead concentrations in the blood of 17 women from Group I decreased to 60.73 μg/L, and in their hair to 1.20 μg/g after 12 months. We observed a significant correlation between lead concentrations and copper levels in the hair of the mothers.
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