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Morphological and biochemical changes in human fibroblast lines induced by anthracyclines during apoptosis

100%

Kania K., Dragojew S., Jozwiak Z.

Cellular and Molecular Biology Letters

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2002

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tom 07

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nr Suppl.

2

Morphological and biochemical changes in human fibroblast lines induced by anthracyclines during apoptosis

100%

Kania K., Dragojew S., Jozwiak Z.

Cellular and Molecular Biology Letters

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2003

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tom 08

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nr 1

We show that treating human trisomie fibroblasts with anthracyclines - aclarubicin, daunorubicin and idarubicin - leads to certain changes in these cells; namely the activation of caspase 3, morphological changes and an increase in the level of intracellular calcium. These results suggest that anthracycline drugs are also able to induce apoptosis in pathological, trisomic cells.

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The induction of apoptosis by daunorubicin and idarubicin in human trisomic and diabetic fibroblasts

88%

Dragojew S., Marczak A., Maszewski J., Ilnicki K., Jozwiak Z.

Cellular and Molecular Biology Letters

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2008

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tom 13

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nr 2

182-194

In this study, we investigated apoptosis induced in human trisomic and diabetic fibroblasts by daunorubicin (DNR) and its derivative, idarubicin (IDA). The cells were incubated with DNR or IDA for 2 h and then cultured in a drug-free medium for a further 2–48 h. The apoptosis in the cultured cell lines was assessed by biochemical analysis. We found that both drugs induced a timedependent loss of mitochondrial membrane potential, and a significant increase in intracellular calcium and caspase-3 activity. Mitochondrial polarization and changes in the level of intracellular calcium were observed during the first 2–6 h after drug treatment. Caspase-3 activation occurred in the late stages of the apoptotic pathway. Our findings also demonstrated that idarubicin was more cytotoxic and more effective than daunorubicin in inducing apoptosis in trisomic and diabetic fibroblasts.

Ograniczanie wyników

3 Cellular and Molecular Biology Letters

3 Dragojew S.

3 Jozwiak Z.

2 Kania K.

1 Ilnicki K.

1 Marczak A.

1 Maszewski J.

1 2008

1 2003

1 2002

Morphological and biochemical changes in human fibroblast lines induced by anthracyclines during apoptosis

Morphological and biochemical changes in human fibroblast lines induced by anthracyclines during apoptosis

The induction of apoptosis by daunorubicin and idarubicin in human trisomic and diabetic fibroblasts