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The search for genes with that positively affect physical fitness is a difficult process. Physical fitness is determined by numerous genes, and its genetic determinants are modified by environmental factors. The map of candidate genes that can potentially affect physical fitness becomes larger every year, and currently it contains more than 200 genes associated with such aspects as respiratory and cardiovascular stability; body build and composition – especially muscle mass and strength; carbohydrate and lipid metabolism; response to training; and exercise intolerance. The inclusion of the genetic component in physiological and biochemical studies would permit drawing a representation of predispositions for each athlete interested in practicing high performance sports and would be a valuable coaching aid in the process of training individualization.
Introduction. Physical performance displays a great interindividual variance in both general population and among well-rained athletes. Genetic factor has an important contribution in this variance. The aim of this study was to examine the association between maximal oxygen uptake and genetic variants of mitochondrial NADH dehydrogenase subunit 5 gene (mtND5) in Caucasians from Poland. Material and Methods. The studies were carried out in a group of 154 men and 85 women, professional athletes representing various sports and fi tness levels and students of the University of Physical Education in Poznań. Physiological and molecular procedures were used, i.e. direct measurement of maximal oxygen uptake (VO₂max) and SNP 13470 G>C polymorphism of the mitochondrial NADH dehydrogenase subunit 5 gene (mtND5) was determined by restriction fragments length polymorphism (PCR-RFLP). Results. We have found that maximal oxygen uptake is associated with BamHI+/+ homoplasmic variant of the mtND5 gene in Caucasians from Poland. We have also observed positive infl uence of BamHI+ allele on level of maximal oxygen uptake (VO₂max).
High-altitude mountaineering involves exposure to reduced partial oxygen pressure, which leads to a number of psychical and physical disturbances in the climber’s body and has an impact on the function of the central nervous system. These disorders can be intensified by external environmental factors such as energy deficit, fatigue, high true altitude, stress and cold. The climber’s central nervous system can experience functional and morphological changes, mostly of a non-permanent character. All these factors can lead to perception disorders and changes of behavior in climbers as compared with their perception abilities and behaviors at lower altitudes. Problems with concentration, rational assessment of situations and one’s own capabilities – and in extreme cases – delusions or autistic symptoms may also occur. Emphatic behaviors of climbers at high altitudes seem to be seriously hindered, since their brain function focuses on survival. An assessment of ethical behaviors in such conditions is very difficult as humans normally behave ethically at “sea-level” where the brain functions properly in under appropriate partial oxygen pressure.
 Uncoupling proteins 2 and 3 (UCP2 and UCP3) as mitochondrial electron transporters are involved in regulation of ATP production and energy dissipation as heat. Energy efficiency plays an important role in physical performance, especially in aerobic fitness. The aim of this study was to examine the association between maximal oxygen uptake and genetic variants of the UCP2 and UCP3 genes. The studies were carried out in a group of 154 men and 85 women, professional athletes representing various sports and fitness levels and students of the University of Physical Education in Poznań. Physiological and molecular procedures were used, i.e. direct measurement of maximum oxygen uptake (VO2max) and analysis of an insertion/deletion (I/D) polymorphism in the 3'untranslated region of exon 8 of the UCP2 gene and a C>T substitution in exon 5 (Y210Y) of the UCP3 gene. No statistically significant associations were found, only certain trends. Insertion allele (I) of the I/D UCP2 and the T allele of the UCP3 gene were favourable in obtaining higher VO2max level and might be considered as endurance-related alleles.
Introduction. Numerous studies have focused on the association between I/D ACE and physical fi tness; however, this association in professional hockey players has never been recognized. Aim of the Study. The study examined the distribution of Alu insertion (I)/deletion (D) angiotensin converting enzyme (ACE) genotypes in elite male professional fi eld hockey players. Material and Methods. The effect of Alu insertion (I)/deletion (D) angiotensin converting enzyme (ACE) genotypes on motor skills and maximal oxygen uptake (VO₂max) in 47 elite male fi eld hockey players was studied. Genotyping for ACE I/D was performed using a polymerase chain reaction on DNA from leucocytes. The studied motor skills such as speed – 20 m run, power – vertical jump, recovery – step-test, speed endurance (15 x 20 m) shuttle run, were established using functional tests. The VO₂max was measured during progressive exercise test till exhaustion. Results. The authors do not confi rm some literature data that D allele favours endurance ability. We did not detect signifi cant genotype effects of ACE on the analyzed traits; how-ever a tendency for decreased performance of individuals with the DD genotype was noted for vertical jump, power peak and power. Conclusions. Analysis of the genetic profi le of ACE I/D may provide supplemetary information on a player’s predispositions to exercise with specifi c energy requirements.
 Physical fitness is a trait determined by multiple genes, and its genetic basis is modified by numerous environmental factors. The present study examines the effects of the (CA)n tandem repeats polymorphism in IGFI gene and SNP Alw21I restriction site -202 A>C polymorphism in IGF1BP3 on VO2max - a physiological index of aerobic capacity of high heritability. The study sample consisted of 239 (154 male and 85 female) students of the University School of Physical Education in Poznań and athletes practicing various sports, including members of the Polish national team. An association was found between -202 A/C polymorphism of IGFBP3 gene with VO2max in men. Higher VO2max values were attained by men with CC genotype, especially male athletes practicing endurance sports and sports featuring energy metabolism of aerobic/anaerobic character. A statistically significant influence of allele 188 and genotype 188/188 of tandem repeats (CA)n polymorphism of IGF1 gene on VO2max was found in women. Also, lower values of maximal oxygen uptake were noted in individuals with allele 186 or genotype 186/186, and higher VO2max values in athletes with allele 194.
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