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Glycoconjugates with NeuAc-NeuAc-Gal-Glc are more effective at preventing adhesion of Helicobacter pylori to gastric epithelial cells than glycoconjugates with NeuAc-Gal-Glc

100%

Hata Y., Murakami M., Okabe S.

Journal of Physiology and Pharmacology

2004

tom 55

nr 3

Helicobacter pylori (H. pylori) adheres to human gastric epithelial cells, eliciting various gastroduodenal diseases. Gangliosides play a critical role in bacterial adhesion to cell surfaces. The present study examined how residues of gangliosides are important for inhibition of adhesion of H. pylori to MKN-45 cells. We measured adhesion or detachment effects of gangliosides on the interaction between MKN-45 cells and H. pylori, as well as interleukin-8 production. Among the gangliosides, O-Ac-GD3, GT1b, GD1a, GD1b, GT1a, and GD3 had potent dose dependent inhibitory effects on adhesion of H. pylori to MKN-45 cells, interleukin-8 production, and vacuole formation induced by H. pylori toxin binding to Vero cells. GD3 also accelerated bacterial detachment of MKN-45 cells with adherent H. pylori in a dose dependent manner. Such results strongly suggest that the mechanism involved in the inhibition of H. pylori adhesion is mediated by the variations of the residues of the NeuAc-NeuAc-Gal-Glc chain of gangliosides. NeuAc-NeuAc-Gal-Glc exhibits a more inhibitory effect on adhesion than the NeuAc-Gal-Glc chain. Such gangioside and oligosaccrharide sequences appear to have therapeutic importance for prevention of H. pylori adhesion, as well as reduction of both inflammation and gastric mucosal injuries.

Characterization of small granular sized starches - amaranthus and quinoa starches

64%

Inouchi N., Nishi K., Tanaka S., Asai T., Kawase Y., Hata Y., Konishi Y., Yue S., Fuwa H.

Żywność Technologia Jakość. Suplement

1998

tom 05

nr 4

131-139

Ograniczanie wyników

1 Journal of Physiology and Pharmacology

1 Żywność Technologia Jakość. Suplement

2 Hata Y.

1 Asai T.

1 Fuwa H.

1 Inouchi N.

1 Kawase Y.

1 Konishi Y.

1 Murakami M.

1 Nishi K.

1 Okabe S.

1 Tanaka S.

1 Yue S.

1 2004

1 1998

Wyniki wyszukiwania

Glycoconjugates with NeuAc-NeuAc-Gal-Glc are more effective at preventing adhesion of Helicobacter pylori to gastric epithelial cells than glycoconjugates with NeuAc-Gal-Glc

Characterization of small granular sized starches - amaranthus and quinoa starches