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The activity of serum paraoxonase and level of conjugated dienes in stroke patients

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Michalak S., Kazimierski R., Hellmann A., Wencel-Warot A., Kocialkowska D., Kozubski W.
Acta Neurobiologiae Experimentalis
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2009
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tom 69
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nr 1
Paraoxonase (PON) protects low-density lipoproteins from oxidation. Gln192Arg genotype of PON was identifi ed as a risk factor for stroke. The aim of our study was to evaluate the activity of the esterase and concentration of conjugated dienes (CD) in the early phase of stroke and its clinical signifi cance. Material and methods: The PON activity and conjugated dienes (CD) concentrations were analyzed within fi rst 24 hours after stroke onset by means of spectrophotometric methods. Results: We included into the study 424 persons [403 ischemic stroke (IS) patients, aged 67 ± 12 and 21 patients with IS secondary hemorrhagic transformation (SHT), aged 69 ± 11 and 12 age-matched healthy controls]. The PON activity was lower in SHT patients (13.2; interquartile range 2.3ñ67.1 U/L) comparing to IS patients (63.7; 40.2ñ145.9 U/L) and controls (42.34; 38.98ñ57.44 U/L) (P<0.05). There was no signifi cant difference in CD concentration between IS and SHT patients (P>0.05). Multiple regression analysis revealed correlations between CD concentration and Barthel index in IS and SHT, and between PON activity and Barthel index in HT patients. Conclusion The serum PON activity in early phase of stroke was signifi cantly lower in SHT than in IS patients. PON activity showed correlation with clinical outcome in SHT patients whereas CD concentrations correlated with the outcome in both IS and SHT groups.
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Can deep vein thrombosis be predicted after varicose vein operation in women in rural areas?

100%
Warot M., Synowiec T., Wencel-Warot A., Daroszewski P., Bojar I., Micker M., Checinski P.
Annals of Agricultural and Environmental Medicine
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2014
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tom 21
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nr 3
Introduction. Chronic venous disease is a group of symptoms caused by functional and structural defects of the venous vessels. One of the most common aspects of this disease is the occurrence of varicose veins. There are many ways of prevention and treatment of varicose veins, but in Poland the leading one is still surgery. As in every medical procedure there is the possibility of some complications. One of them is deep vein thrombosis (DVT). The diagnosis of DVT can be difficult, especially when access to a specialist is limited, such as in case of rural patients. The aim of the study. The aim of the study was estimation of the influence of LMWH primary prophylaxis on the formation of postoperative DVT, as well as sensitivity and specificity of clinical examination and D-dimer value in diagnosis of postoperative DVT in women. Materials and methods. The study was conducted in a group of 93 women operated on in the Department of General, Vascular Surgery and Angiology at the Karol Marcinkowski University of Medical Sciences in Poznań, Poland. The patients had undergone a varicose vein operation and were randomly divided into two groups: A – 48 women receiving LMWH during two days of the perioperative period, B – 45 women receiving LMWH during seven days of the perioperative period. Results. There was no significant difference in the postoperative DVT complications in both groups. The value of D-dimer > 0.987 mcg/ml and swelling > 1.5 cm of shin (in comparison to the preoperative period) plays a significant role in diagnosis of DVT. Conclusions. The extended primary prophylaxis with LMWH does not affect the amount or quality of thrombotic complications after varicose vein operation. If the DVT occurs, the evaluation of the D – dimer and careful clinical examination can be a useful method for its diagnosis.
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