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1

Perception disorders and behavior changes in high-altitude mountaineers

100%
Banasiewicz T., Przybyl M., Holdys J.
Trends in Sport Sciences
|
2014
|
tom 21
|
nr 1
High-altitude mountaineering involves exposure to reduced partial oxygen pressure, which leads to a number of psychical and physical disturbances in the climber’s body and has an impact on the function of the central nervous system. These disorders can be intensified by external environmental factors such as energy deficit, fatigue, high true altitude, stress and cold. The climber’s central nervous system can experience functional and morphological changes, mostly of a non-permanent character. All these factors can lead to perception disorders and changes of behavior in climbers as compared with their perception abilities and behaviors at lower altitudes. Problems with concentration, rational assessment of situations and one’s own capabilities – and in extreme cases – delusions or autistic symptoms may also occur. Emphatic behaviors of climbers at high altitudes seem to be seriously hindered, since their brain function focuses on survival. An assessment of ethical behaviors in such conditions is very difficult as humans normally behave ethically at “sea-level” where the brain functions properly in under appropriate partial oxygen pressure.
2

Wstepne wyniki badan genu receptora ryanodiny [RYR1] sugerujacecgo jego wystepowanie w genomie bazanta [Phasianus colchicus L.]

100%
Gronek P., Buczynski J., Torgowski J., Banasiewicz T.
Roczniki Akademii Rolniczej w Poznaniu. Zootechnika
|
1999
|
tom 51
123-126
3

Novel mutation in the RYR1 gene of the red fox [Vulpes vulpes]

88%
Gronek P., Zajac M., Buczynski J., Banasiewicz T., Slomski R.
Roczniki Akademii Rolniczej w Poznaniu. Zootechnika
|
1999
|
tom 51
127-133
4

Discrepancy between clinical and histological effects of DHA supplementation in a rat model of pouchitis

76%
Drzymala-Czyz S., Banasiewicz T., Tubacka M., Tarasiuk-Rusek A., Majewski P., Drews M., Walkowiak J.
Folia Histochemica et Cytobiologica
|
2012
|
tom 50
|
nr 1
5

The ryanodine receptor gene [RYR1] occurs in ducks genome

76%
Gronek P., Napierala D., Kontecka H., Plawski A., Banasiewicz T., Slomski R.
Roczniki Akademii Rolniczej w Poznaniu. Zootechnika
|
1999
|
tom 51
135-139
6

In vitro studies of antibacterial and antifungal wound dressings comprising H2TiO3 and SiO2 nanoparticles

76%
Krokowicz L., Tomczak H., Bobkiewicz A., Mackiewicz J., Marciniak R., Drews M., Banasiewicz T.
Polish Journal of Microbiology
|
2015
|
tom 64
|
nr 2
The incidence rate of the infected and complex wound is established at approximately 40 000/1 million of the world’s adult population. The aim of this study was to assess the efficiency of three novel types of wound dressings comprising sodium chloride, metatitanic acid and silicon dioxide nanoparticles. The study design was to prove their antimicrobial properties against the microorganisms most commonly causing wound infections. The study evaluated the antimicrobial effect of tested dressings on referenced strains of bacteria (ATCC collection, Argenta, Poland) and strains of fungi species (our own collection of fungi cultured from patients). The dressings were tested with both bacterial and fungal strains on solid media (Mueller-Hinton, Sobouraud, bioMerieux, France) in the standard method. The results confirmed the inhibition of growth of bacteria and revealed zones of inhibition for Escherichia coli, Staphylococcus aureus and Enterococcus faecalis. Significant zones of inhibition were established for Staphylococcus aureus and for fungi species of the Candida sp. These results would be crucial due to the fact of the low availability of antifungal therapeutics for both systemic and topical usage. Moreover, the current standard of antifungal treatment is associated with high costs and high toxicity in general. The preliminary results are very promising but further studies are necessary. Based on the obtained results, the tested dressings may contribute to the development of the surgical armamentarium of complex wound management in the near future.
7

Trace elements and rat pouchitis

76%
Drzymala-Czyz S., Banasiewicz T., Walas S., Koscinski T., Wenska-Chyzy E., Drews M., Walkowiak J.
Acta Biochimica Polonica
|
2012
|
tom 59
|
nr 4
 The procedure of restorative proctocolectomy is associated with a complete removal of the colon and slight reduction of ileum length, which together can lead to systemic shortages of trace elements. Inflammatory changes in the pouch mucosa may also have some impact. However, there is no data on trace elements in pouchitis. Therefore, in the present study we aimed to assess the effect of acute pouchitis on the status of selected trace elements in rats. Restorative proctocolectomy with the construction of intestinal J-pouch was performed in twenty-four Wistar rats. Three weeks after the surgery, pouchitis was induced. Eight untreated rats created the control group. Liver concentrations of selected micronutrients (Zn, Cu, Co, Mn, Se) were measured in both groups six weeks later, using inductively coupled plasma mass spectrometry. Liver concentrations of trace elements did not differ between the study and the control groups. However, copper, cobalt and selenium concentrations [μg/g] were statistically lower (p<0.02, p<0.05 and p<0.04, respectively) in rats with severe pouchitis (n=9) as compared with rats with mild pouchitis (n=7) [median (range): Cu - 7.05 (3.02-14.57) vs 10.47 (5.16-14.97); Co - 0.55 (0.37-0.96) vs 0.61 (0.52-0.86); Se - 1.17 (0.69-1.54) vs 1.18 (0.29-1.91)]. In conclusion, it seems that acute pouchitis can lead to a significant deficiency of trace elements.
8

A note on ryanodine receptor gene [ryr 1] occurence in the anserine genome

76%
Gronek P., Napierala D., Plawski A., Rosinski A., Slomski R., Banasiewicz T.
Journal of Animal and Feed Sciences
|
1999
|
tom 08
|
nr 2
203-207
9

Sequence polymorphism of exon 17 of the ryanodine receptor gene [ryr1] in the Canidae

76%
Gronek P., Nuc K., Napierala D., Plawski A., Zajac M., Banasiewicz T., Slomski R.
Journal of Animal and Feed Sciences
|
2000
|
tom 09
|
nr 4
10
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Homology of DNA sequences encompassing the malignant hyperthermia mutation site in the human, porcine, and zebrine ryrl gene

76%
Gronek P., Slomski R., Lisiecka D., Plawski A., Nuc K., Banasiewicz T.
Journal of Applied Genetics
|
1998
|
tom 39
|
nr 3
The RYR1 gene encoding the Ca²⁺ channel of sarcoplasmic reticulum of human skeletal muscle has been cloned and its nucleotide sequence has been determined earlier. We have used the polymerase chain reaction single strand conformation polymorphism (PCR-SSCP), and sequencing analysis for human, porcine (Sus scrofa), and zebrine (Equus grevyi) ryanodine receptor (ryrl) gene. The fragment of exon 17 of the ryr1 gene was characterized by a high homology between all the analysed species (substitution of a nucleotide is underlined): porcine ryr1 ¹⁸³⁴GTG GCC GTG CGC TCC AAC CAA GAT CT¹⁸⁵⁹ human RYR1 ¹⁸³¹GTG GCC GTG CGC TCC AAC CAA GAT CT¹⁸⁵⁶ zebrine ryr1 GTG GCC GTG CGC TCC AAC CAA GAC CT.
11

Lactose intolerance, lactose malabsorption and genetic predisposition to adult-type hypolactasia in patients after restorative proctocolectomy

64%
Walkowiak J., Fidler-Witon E., Glapa A., Paszkowski J., Borejsza-Wysocki M., Miskiewicz-Chotnicka A., Banasiewicz T., Lisowska A.
Acta Biochimica Polonica
|
2019
|
tom 66
|
nr 2
12

Inflammatory bowel disease — is there something new in the immunological background?

64%
Marszalek A., Marciniak R., Szkaradkiewicz A., Wasilewska A., Chudzicka-Strugala I., Ziuziakowska H., Zebrowska M., Majewski P., Banasiewicz T., Drews M.
Folia Histochemica et Cytobiologica
|
2011
|
tom 49
|
nr 2
13

Conflicting results of non-invasive methods for detection of Helicobacter pylori infection in children with celiac disease - a preliminary study

64%
Jozefczuk J., Madry E., Nowak J., Walkowiak M., Lochocka K., Banasiewicz T., Plawski A., Kwiecien J., Walkowiak J.
Acta Biochimica Polonica
|
2016
|
tom 63
|
nr 1
14

Inulin supplementation in rat model of pouchitis

64%
Drzymala-Czyz S., Banasiewicz T., Tubacka M., Majewski P., Biczysko M., Koscinski T., Drews M., Walkowiak J.
Acta Biochimica Polonica
|
2011
|
tom 58
|
nr 3
Available data indicates potential effectiveness of prebiotic therapy in alleviating inflammation and prolonging the remission in inflammatory bowel disease. Documented successes of such therapies were the basis for this study. So far, there is no data related to the effectiveness of inulin application in symptomatic or severe pouchitis in humans or in animal model. The aim of the study was to determine the effect of inulin supplementation on the expression of intestinal inflammation and feeding efficiency in rats with induced pouchitis. Twenty-four Wistar rats were operated. After induction of pouchitis animals were randomly divided into control and supplementation groups receiving, respectively, semi-synthetic diet with or without inulin (in a lower (LD) or higher (HD) dose: 2.5 % or 5 % of total dietary content of mass) for a period of 6 weeks. Selected nutritional parameters were assessed throughout the study. Histopathological and immunohistochemical analysis of pouch mucosa specimens was also performed. The energy intake, weight gain, feeding efficiency, quality of stools were comparable in all studied groups. The intensity of inflammation (Moskovitz scale) and adaptive changes (Laumonier scale) did not differ between compared groups. The tissue expression of pro- and anti-inflammatory interleukins (IL-1α, IL-6, IL-10 and IL-12) was not different either. Inulin supplementation does not improve the quality of stools or the expression of intestinal inflammation in rats with induced pouchitis. It has no impact on the intensity of pouch adaptation or on feeding efficiency.
15

Novel mutation in the RYR1 gene of the wolf [Canis lupus]

64%
Gronek P., Nuc K., Napierala D., Plawski A., Zajac M., Bereszynski A., Banasiewicz T., Slomski R.
Animal Science Papers and Reports
|
1998
|
tom 16
|
nr 4
231-236
16

Development of a new, simple and cost-effective diagnostic tool for genetic screening of hereditary colorectal cancer - the DNA microarray assay

52%
Stojcev Z., Banasiewicz T., Kaszuba M., Sikorski A., Szczepkowski M., Bobkiewicz A., Paszkowski J., Krokowicz L., Biczysko M., Szmeja J., Jurkowska M., Majewski P., Mackiewicz A., Lamperska K., Drews M., Wojciechowicz J.
Acta Biochimica Polonica
|
2013
|
tom 60
|
nr 2
 Detection of mutations in families with a hereditary predisposition to colon cancer gives an opportunity to precisely define the high-risk group. 36 patients operated on for colon cancer, with familiar prevalence of this malignancy, were investigated using the DNA microarrays method with the potential detection of 170 mutations in MLH1, MSH2, MSH6, CHEK2, and NOD2 genes. In microarrays analysis of DNA in 9 patients (25% of the investigated group), 6 different mutations were found. The effectiveness of genetic screening using the microarray method is comparable to the effectiveness of other, much more expensive and time-consuming methods.
17

Comparison of fecal pyruvate kinase isoform M2 and calprotectin in assessment of pediatric inflammatory bowel disease severity and activity

52%
Czub E., Nowak J. K., Szaflarska-Poplawska A., Grzybowska-Chlebowczyk U., Landowski P., Moczko J., Adamczak D., Mankowski P., Banasiewicz T., Plawski A., Walkowiak J.
Acta Biochimica Polonica
|
2014
|
tom 61
|
nr 1
 Aims: Accurate assessment of inflammatory bowel disease (IBD) activity is the cornerstone of effective therapy. Fecal M2 isoform of pyruvate kinase (M2-PK) and fecal calprotectin (FC) are noninvasive markers of mucosal inflammation in IBD. The aim of this study was to compare performance of M2-PK and FC in assessment of pediatric ulcerative colitis (UC) and Crohn's disease (CD) severity and activity. Materials and methods: 121 patients with IBD, including 75 with UC and 46 with CD were recruited. Control group consisted of 35 healthy children (HS). Patients were assigned to groups depending on disease severity and activity. M2-PK and calprotectin concentration were determined in stool samples using ELISA. Areas under receiver operating characteristic curves (AUC) for FC and M2-PK with cut-off level at which M2-PK specificity was matching FC specificity were calculated and compared. Results: Performance of M2-PK at identifying patients with IBD, UC and CD among HS was inferior to FC. The differences in AUC were respectively: -0.10 (95% confidence interval [CI] [-0.13-(-0.06)], p<0.0001), -0.14 (95% CI [-0.19-(-0.09)], p<0.0001) and -0.03 (95% CI [-0.05-(-0.001)], p<0.02). M2-PK was inferior to FC in discriminating patients with mild UC from those with HS (AUC difference -0.23, 95% CI [-0.31-(-0.15)], p<0.0001). Conclusions: FC reflects pediatric IBD severity and activity better than M2-PK. This difference is particularly pronounced when identifying patients with mild UC and UC in remission.
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