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Inhibition of proteolytic processing of adenoviral proteins by epsilon-aminocaproic acid and ambenum in adenovirus-infected cells

100%

Nosach L., Dyachenko N., Zhovnovataya V., Lozinskiy M., Lozitsky V.

Acta Biochimica Polonica

2002

tom 49

nr 4

Maturation of adenovirus particles is markedly affected by proteolytic processing. The possibility for blocking the conversion of precursor structural core protein (preVII) into mature structure protein VII by officinal drugs £-aminocaproic acid and ambenum has been demonstrated in Hep-2 cells infected with adenovirus. Proteolytic processing may be regarded as one of the targets for inhibiting adenovirus reproduction.

N4-amino-acid derivatives of 6-azacytidine: structure - activity relationship

86%

Alexeeva I., Palchikovskaya L., Shalamay A., Nosach L., Zhovnovataya V., Povnitsa O., Dyachenko N.

Acta Biochimica Polonica

2000

tom 47

nr 1

Several N4-derivatives of 6-azacytidine were synthesized using of Vorbrueggen's condensation method. Their antiviral activity with respect to the adenovirus serotypes 2 and 5 in Hep-2 cells culture was studied and primary specific activity was determined. Correlation between chemical structure of new 6-azacytidine derivatives and their biological properties is discussed.

Ograniczanie wyników

2 Acta Biochimica Polonica

2 Dyachenko N.

2 Nosach L.

2 Zhovnovataya V.

1 Alexeeva I.

1 Lozinskiy M.

1 Lozitsky V.

1 Palchikovskaya L.

1 Povnitsa O.

1 Shalamay A.

1 2002

1 2000

Wyniki wyszukiwania

Inhibition of proteolytic processing of adenoviral proteins by epsilon-aminocaproic acid and ambenum in adenovirus-infected cells

N4-amino-acid derivatives of 6-azacytidine: structure - activity relationship