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1

Receptor dla interleukiny 2: struktura, funkcja i przydatnosc kliniczna w schorzeniach rozrostowych u doroslych i dzieci

100%
Bien E., Balcerska A.
Postępy Higieny i Medycyny Doświadczalnej
|
2003
|
tom 57
|
nr 6
669-683
2

Ocena skutecznosci naturalnego interferonu ALFA [HUIFN ALFA] w stymulowaniu eliminacji wirusa hepatitis B u dzieci po zakonczeniu leczenia przeciwnowotworowego

71%
Bohdan Z., Balcerska A., Drozynska E., Kozielska E., Sierota D.
Acta Biologica et Medica
|
1993
|
tom 20
81-87
3

Cytometric evaluation of transferrin receptor 1 (CD71) in childhood acute lymphoblastic leukemia

61%
Ploszynska A., Ruckemann-Dziurdzinska K., Jozwik A., Mikosik A., Lisowska K., Balcerska A., Witkowski J. M.
Folia Histochemica et Cytobiologica
|
2012
|
tom 50
|
nr 2
4

Association between intestinal and antioxidant barriers in children with cancer

61%
Stachowicz-Stencel T., Synakiewicz A., Owczarzak A., Sliwinska A., Lysiak-Szydlowska W., Balcerska A.
Acta Biochimica Polonica
|
2012
|
tom 59
|
nr 2
Objective: Reactive oxygen species (ROS) play a role in cancerogenesis processing and damage tissues. Furthermore, oncological treatment may impair proper function of the gut barrier. The aim of this study was to measure intestinal permeability in children in clinical remission for solid tumours and to search for a possible relationship between free radicals and the intestinal barrier. No such investigation in children has been reported so far. Research Methods and Procedures: The prospective study consisted of 19 paediatric patients with cancer after completion of chemotherapy. 32 healthy children from the outpatients clinics were recruited for measurement of intestinal permeability and antioxidant barrier as a control group. Intestinal permeability was assessed by measurement of urinary lactulose and mannitol after oral challenge. Antioxidant enzymes: superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) in erythrocytes were assessed. Ischemia modified albumin (IMA) concentration was measured in serum. Results: Cancer patients excreted less mannitol and more lactulose versus controls. The ratio of lactulose to mannitol was significantly higher in oncological children vs control (mean 0.188 and 0.0453, respectively, p=0.0006,). Significantly higher IMA level in the oncological group vs control was noted (mean 123.8 and 87.3 U/ml, respectively, p=0.0037). No correlation between intestinal permeability and oxidative stress barrier was found. Conclusions: Our data shows that intestinal barrier is damaged in paediatric cancer patients after chemotherapy. IMA is believed to play a protective role in the defence against tissue damage. No correlation was found between these two barriers.
5

Ocena wplywu interferonu ALFA na przebieg choroby nowotworowej u dzieci ze zlosliwymi guzami litymi

61%
Balcerska A., Bohdan Z., Drozynska E., Kozielska E., Szarszewski A., Sierota D.
Acta Biologica et Medica
|
1993
|
tom 20
61-70
6

Cytogenetic analysis and clinical significance of chromosome 7 aberrations in acute leukaemia

61%
Brozek I., Babinska M., Kardas I., Wozniak A., Balcerska A., Hellmann A., Limon J.
Journal of Applied Genetics
|
2003
|
tom 44
|
nr 3
7

Increasing incidence of diabetes mellitus type 1 in children - the role of environmental factors

61%
Mysliwiec M., Balcerska A., Zorena K., Jedrzejczyk A., Malinowska E., Mysliwska J.
Polish Journal of Environmental Studies
|
2007
|
tom 16
|
nr 1
The incidence of diabetes type 1, a chronic autoimmune disease, may reach the status of an epidemic in the 21st century. The highest incidence of diabetes in the world is observed in Finland. However, in the last 8 years a dynamic rise has been observed in Poland, moving the country toward an intermediate level incidence classification. Environmental factors seem to play a part in the observed increase in diabetes incidence both in Poland and in the world since, by acting on genetically predisposed ground prompt to auto-aggression, they may provoke disease occurrence. The study was carried out on a group of 511 children aged 0-15 years (255 girls and 256 boys). During the period of analysis (1998-2005) almost a two-fold increase in the diabetes incidence rate was observed (1998-10.4 vs 2005-20.4). The identification of all the factors increasing the risk of diabetes mellitus type 1 shall allow for understanding of diabetes ethiopathogenesis, and thus might create a chance for development of new prevention strategies.
8

Evaluation of the efficacy of natural human interferon alpha lozenges on the clinical course of childhood neoplasia and in chronic hepatitis B virus infection in patients who were successfully treated for pediatric malignancies

61%
Balcerska A., Bohdan Z., Drozynska E., Kozielska E., Szarszewski A., Georgiades J. A.
Archivum Immunologiae et Therapiae Experimentalis
|
1993
|
tom 41
|
nr 3-4
9

In vitro activity of axazaphosphorines in childhood acute leukemia: preliminary report

42%
Styczynski J., Wysocki M., Debski R., Balwierz W., Rokicka-Milewska R., Matysiak M., Balcerska A., Kowalczyk J., Wachowiak J., Sonta-Jakimczyk D., Chybicka A.
Acta Biochimica Polonica
|
2002
|
tom 49
|
nr 1
Glufosfamide (β-D-glucosyHfosfamide mustard) is a new agent for cancer chemo­therapy. Its pharmacology is similar to commonly used oxazaphosphorines, but it does not require activation by hepatic cytochrome P-450 and preclinically demon­strates lower nephrotoxicity and myelosuppression than ifosfamide. The aim of the study was a comparison of the drug resistance profiles of glufosfamide and other oxazaphosphorines in childhood acute leukemias. Leukemic cells, taken from chil­dren with ALL on diagnosis (n = 41), ALL on relapse (n = 12) and AML on diagnosis (n = 13) were analyzed by means of the MTT assay. The following drugs were tested: glufosfamide (GLU), 4-HOO-ifosfamide (IFO), 4-HOO-cyclophosphamide (CYC) and mafosfamide cyclohexylamine salt (MAF). In the group of initial ALL samples median cytotoxicity values for GLU, IFO, CYC and MAF were 15.5, 33.8, 15.7 and 7.8,«M, re­spectively. In comparison with initial ALL samples, the relative resistance for GLU and IFO in relapsed ALL samples was 1.9 (p = 0.049) and 1.3 (ns), and in initial AML samples 31 (p < 0.001) and 5 (p = 0.001), respectively. All oxazaphosphorines pre­sented highly significant cross-resistance. Glufosfamide presented high activity against lymphoblasts both on diagnosis and on relapse.
10

Cross-resistance to five glucocorticoids in childhood acute lymphoblastic and non-lymphoblastic leukemia samples tested by the MTT assay: Preliminary report

42%
Styczynski J., Wysocki M., Debski R., Balwierz W., Rokicka-Milewska R., Matysiak M., Balcerska A., Kowalczyk J., Wachowiak J., Sonta-Jakimczyk D., Chybicka A.
Acta Biochimica Polonica
|
2002
|
tom 49
|
nr 1
In vitro antileukemic activity of five glucocorticoids and their cross-resistance pat­tern in childhood acute lymphoblastic and non-lymphoblastic leukemia were deter­mined by means of the MTT assay in 25 leukemia cell samples of childhood acute leukemias. The equivalent antileukemic concentrations of the drugs tested were: 34 uM hydrocortisone (HC), 8 uM prednisolone (PRE), 1.5 uM methylprednisolone (MPR), 0.44 uM dexamethasone (DX) and 0.22 Mbetamethasone (BET). In comparison with initial ALL cell samples, the relapsed ALL group was more resistant to PRE (38-fold, p = 0.044), DX (> 34-fold, p = 0.04), MPR (38-fold), BET (45-fold) and HC (33-fold). TheAMLcell samples were even more resistant to: PRE (>85-fold, p=0.001), DX (> 34-fold, p = 0.004),MPR(> 69-fold, p = 0.036), BET (> 69-fold, p = 0.038) and HC (54-fold, p = 0.059) when compared with ALL on initial diagnosis. A significant cross-resistance among all the glucocorticoids used was found. Only in some individual cases the cross-resistance was less pronounced.
11

The influence of intracellular idarubicin and daunorubicin levels on drug cytotoxicity in childhood acute leukemia

42%
Styczynski J., Wysocki M., Debski R., Kurylak A., Balwierz W., Rokicka-Milewska R., Matysiak M., Balcerska A., Kowalczyk J., Wachowiak J., Sonta-Jakimczyk D., Chybicka A.
Acta Biochimica Polonica
|
2002
|
tom 49
|
nr 1
Uptake and efflux of two anthracyclines, idarubicin (IDA) and daunorubicin (DNR), was studied in childhood acute leukemia samples. A comparison of IDA and DNR transport phenomena in relation to drug cytotoxicity and expression of P-glycoprotein (PGP) was made. Intracellular content of IDA/DNR was determined by flow cytometry using the fluorescent properties of the drugs. In vitro drug cytotoxicity was measured by the 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl tetrazolium bromide (MTT) assay. PGP expression was analysed by flow cytometry. The uptake and efflux rates were non-significantly higher for IDA than DNR. There were no differences between three types of leukemia with respect to drug content during accumulation and retention. After correction for the cell volume, intracellular concentration of both drugs in each moment of uptake and efflux was significantly lower in relapsed ALL and AML samples in comparison with initial ALL cells. Efflux, but not uptake, of both drugs was inversely correlated with PGP expression and IDA, but not DNR, cytotoxicity. The cytotoxicity was correlated with drug accumulation for both drugs and with drug retention for IDA. In conclusion, it seems that (1) intracellular content was related to the lipophilic properties of the drugs rather than to the type of leukemia, (2) decreased intracellular concentration of both drugs might have an impact on compromised therapy results in AML and relapsed ALL children, (3) IDA presents higher cytotoxicity, which possibly might be decreased by the presence of PGP. These results might have a practical impact on the rational design of new chemotherapy protocols.
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