Wyniki wyszukiwania

1

Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik

Wpływ wysiłku fizycznego na wartość wybranych wskaźników hematologicznych i antyoksydacyjnych u koni będących w różnych okresach treningu

100%

Ogonski T., Pikula R., Kopczynski P.

Acta Scientiarum Polonorum. Zootechnica

|

2010

|

tom 09

|

nr 4

Celem przedstawionych w pracy badań było określenie wpływu wysiłku, w rożnych fazach treningu, na wybrane wskaźniki hematologiczne i status antyoksydacyjny krwi u koni użytkowanych rekreacyjnie i sportowo. Uzyskane wyniki wskazują, że stopień wytrenowania i przygotowania koni do wysiłku można ocenić, badając wybrane wskaźniki hematologiczne w połączeniu z oceną sprawności układu antyoksydacyjnego krwi koni. Parametrami wskazującymi na dobre przygotowanie konia do pracy tlenowej są wysoka spoczynkowa i powysiłkowa liczba erytrocytow i ilość zawartej w nich hemoglobiny oraz niewielki powysiłkowy spadek wartości całkowitego potencjału redukcyjnego krwi. Osobniczy charakter uzyskanych wartości wskazuje, że dopiero całoroczne badania i ustalenie indywidualnego profilu metabolicznego konia pozwoli na precyzyjne określenie postępów w treningu i adekwatnej reakcji ze strony organizmu konia na wysiłek.

2

Doksorubicyna - nowe oblicze starego leku

100%

Lipinska N., Kopczynski P., Holysz H., Rubis B.

Postępy Biologii Komórki

|

2013

|

tom 40

|

nr 4

3

Udział paraoksonazy 1 (EC 3.1.8.1) w rozwoju miażdżycy

88%

Banaszewska A., Baszczuk A., Kopczynski Z., Thielemann A., Kopczynski P.

Postępy Biologii Komórki

|

2014

|

tom 41

|

nr 3

4

Clinical usefulness of assessing VEGF and soluble receptors sVEGFR-1 and sVEGFR-2 in women with breast cancer

88%

Thielemann A., Baszczuk A., Kopczynski Z., Kopczynski P., Grodecka-Gazdecka S.

Annals of Agricultural and Environmental Medicine

|

2013

|

tom 20

|

nr 2

Introduction. The biological activity of VEGF depends on the presence of its specific receptors on the endothelial surface: VEGFR-1, VEGFR-2, and on their soluble forms sVEGFR-1 and sVEGFR-2. The binding of the membrane-bound receptors with VEGF affects the permeability, proliferation and migration of vascular endothelial cells. This creates the necessary conditions for the vascularisation of solid tumours and for the spread of remote metastases. The sVEGFR-1 and sVEGFR-2 receptors are believed to be natural inhibitors of VEGF. Objective. To determine the clinical usefulness of VEGF and the sVEGFR-1 and sVEGFR-2 receptors level assay in women with primary breast cancer. The assessment also took into account: patient’s age, stage of the disease, histological grade, status of the axillary lymph nodes and size of the primary tumour. Material and methods. The concentrations of VEGF, sVEGFR-1 and sVEGFR-2 were ascertained in 103 women with primary breast cancer. The concentrations of VEGF in the plasma, and those of the soluble receptors sVEGFR-1 and sVEGFR-2 in the serum, were assessed by ELISA, R&D Systems. Results. The study found significantly raised concentrations of VEGF, sVEGFR-1 and sVEGFR-2 in the serum of women with breast cancer, relative to the values obtained from the control group. It was found that with increasing clinical stages of the disease, the levels of VEGF and concentrations of sVEGFR-1 and sVEGFR-2 also increased. Similar findings were noted when assessing the degree of the histological grade of the tumours. Significantly higher values of VEGF protein and the assessed receptors were obtained from women with metastases to the axillary lymph nodes. A positive relationship, though without statistical significance, was noted between the concentration of sVEGFR-2 and the size of the tumour. Conclusions. The high concentrations of the VEGF cytokine and the sVEGFR-1 and sVEGFR-2 receptors in women with breast cancer are responsible for giving rise to the processes of tumour angiogenesis. The concentrations of the VEGF protein and the soluble forms of the receptors sVEGFR-1 and sVEGFR-2 in the serum of breast cancer patients showed positive correlations with the clinical stage of the disease. These results point to the usefulness of VEGF assessment and its soluble receptors in the clinical evaluation of patients with breast cancer.

5

Activity of antioxidant enzymes and concentration of Mn, Cu, Zn and protein in porcine follicular fluid

76%

Lasota B., Ogonski T., Blaszczyk P., Seremak B., Ligocki M., Telesinski A., Kopczynski P.

Acta Scientiarum Polonorum. Zootechnica

|

2011

|

tom 10

|

nr 1

Oxidative metabolism is essential for the gamete and the embryo energy production and is unavoidably associated with generation of reactive oxygen species (ROS). Enzymatic antioxidant defenses are present in the mammalian oocytes, embryos and follicular fluid (FF). An addition of porcine FF to maturation media have positive effects on the IVM and IVF results. The aim of this study was to study the CAT, SOD and GSH-Px activity, as well as Cu, Mn, and Zn concentration in porcine FF collected from the left and the right ovary. The ovaries were collected from 77 gilts at age 8 months. All the analyzed samples of FF revealed active enzymes (24.2·10–3 U · l–1, 2.65·10–3 U · l–1, and 525 U · l–1 for CAT, GSH-Px, and SOD, respectively) and contained Zn, Cu and Mn (13.8·103mol · l–1, 33.3·103 mol · l–1, and 133·10–9 mol · l–1, respectively). In the pFF collected from the left ovary, SOD and GSH-Px activity was higher compared to pFF from the right ovary. On the contrary, the concentration of Cu and Mn was significantly lower in the left ovary pFF. The concentration of Cu ions was negatively correlated with SOD activity. The CAT activity in pFF form left or right ovary did not show any differences.

6

Plasma ghrelin and interleukin-6 levels correlate with body mass index and arterial blood pressure in males with essential hypertension

76%

Gibas-Dorna M., Nowak D., Piatek D., Pupek-Musialik D., Krauss H., Kopczynski P.

Journal of Physiology and Pharmacology

|

2015

|

tom 66

|

nr 3

7

Oxygraphic evaluation of activity of respiratory enzymes in boar's semen

76%

Kopczynski P., Lasota B., Ogonski T., Stankiewicz T., Gaczarzewicz D., Skolmowska M.

Folia Pomeranae Universitatis Technologiae Stetinensis. Agricultura, Alimentaria, Piscaria et Zootechnica

|

2016

|