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Vitamin E, C and Astaxanthin pretreatment prevents high-fat diet induced memory deficits in passive avoidance learning

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Karimi S. A., Komaki A., Salehi L., Sarihi A., Zarei M., Shahidi S., Shahidi S.

Acta Neurobiologiae Experimentalis

2014

tom 74

nr 3

Learning and Memory are impaired by imbalanced diet consumption. The objective of this study was to determine the relation between the chronic consumption of High-fat diet (HFD) and antioxidants on passive avoidance learning (PAL) in male rats. Forty male Wistar rats were randomly assigned into five groups (n=6–8): Control group; consumed an ordinary diet, HFD group; received high-fat diets only, ANO group; which received HFD plus antioxidants (vitamin E, C and Astaxanthin), RHFD; Received the HFD was restricted, RANO; which received restricted HFD plus antioxidants. Following 6 months of controlled dietary in each experimental group, the PAL was assessed using shuttle box apparatus. Our results showed that HFD caused a decrease in step through latency in retention test (STLr) compared to the control group. And antioxidant supplementation caused an increase in STLr in comparison to the control group. According to our results, HFD impairs PAL and the combination of vitamin E, C and Astaxanthin improve PAL deficits in HFD group.

Ograniczanie wyników

1 Acta Neurobiologiae Experimentalis

1 Karimi S. A.

1 Komaki A.

1 Salehi L.

1 Sarihi A.

1 Shahidi S.

1 Zarei M.

1 2014

Wyniki wyszukiwania

Vitamin E, C and Astaxanthin pretreatment prevents high-fat diet induced memory deficits in passive avoidance learning