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1

Influence of age on transmembrane potential and cell surface change of human peripheral blood lymphocytes estimated with fluorescent probes

100%
Witkowski J. M., Mysliwski A.
Folia Histochemica et Cytobiologica
|
1991
|
tom 29
|
nr 3
2

Histony

99%
Mysliwski A.
Postępy Biologii Komórki
|
1974
|
tom 1
|
nr 1
3

Tuftsyna - nowe analogi i wlasciwosci

81%
Wardowska A., Dzierzbicka K., Mysliwski A.
Postępy Biochemii
|
2007
|
tom 53
|
nr 1
60-65
4

Syntetyczne immunomodulatory wzorowane na naturalnych produktach mikroorganizmów

81%
Romanowski P., Dzierzbicka K., Mysliwski A., Kolodziejczyk A. M.
Postępy Biochemii
|
1991
|
tom 37
|
nr 3-4
5

Influence of cortisone on ultrastructure of the sublingual salivary gland in rats

81%
Kostula A., Kozlowska K., Mysliwski A.
Folia Morphologica
|
1976
|
tom 35
|
nr 1
Wpływ kortyzolu na ultrastrukturę ślinianki podjęzykowej szczura
6
Content available remote

The effects of fasting and refeeding on adrenal cortex morphometry and serum concentrations of ACTH and corticosterone in young and old male rats

81%
Kmiec Z., Pokrywka L., Kotlarz G., Mysliwski A.
Journal of Physiology and Pharmacology. Supplement
|
2006
|
tom 57
|
nr 6
77-84
The impairment of homeostatic mechanisms in ageing becomes often apparent upon physiological or pathological stimulation. We have previously shown that fasting and refeeding revealed the existence of age-related changes of carbohydrate and lipid metabolism. Because fuel metabolism is partially controlled by corticosteroids we decided to determine the effects of refeeding on adrenal gland morphometry, ACTH, and corticosterone serum levels in young (5 mo) and (20 mo) old male Wistar rats. Fasting for 48 h did not change serum ACTH and corticosterone in both age groups. ACTH level did not change after 24 h of refeeding in young and old rats. However, in old, but not young animals, refeeding resulted in the decrease of corticosterone serum concentration. The relative weight of adrenal gland (% of body weight) did not change significantly with age (p=0.05). Fasting for 48 h induced in old rats but not in young ones increase of relative adrenal weight, and the volume of the reticular zone. Refeeding reduced adrenal volume, fascicular zone and reticular zone. Refeeding for 24 h decreased the total volume of adrenal gland of old rats due to a decline of the volumes of fascicular and reticular zones. In young rats refeeding reduced the volume of reticular zone. It is concluded that refeeding revealed ageing-dependent decline in the secretion of corticosterone, the key hormone of prolonged stress response.
7

Rola komorek dendrytycznych w regulowaniu aktywnosci ukladu immunologicznego oraz mozliwosci wykorzystania ich w terapii

81%
Wardowska A., Szarynska M., Dzierzbicka K., Mysliwski A.
Postępy Biologii Komórki
|
2007
|
tom 34
|
nr 4
669-682
8

Compensatory effect of TNFalpha on low natural killer activity in the elderly

81%
Mysliwska J., Bryl E., Trzonkowski P., Mysliwski A.
Acta Biochimica Polonica
|
2000
|
tom 47
|
nr 2
Regulatory effect of CD25, an activation antigen the alpha subunit of interleukin 2 receptor (IL2R) on the activity of natural killer (NK) cells was studied in fifty elderly (57-70 years old) and fifty young people (19-35 years old). Cytotoxic NK activity was assessed by 51Cr release assay, the levels of interleukin 2 (IL2) and tumour necrosis factors alpha (TNFalpha) were measured using bioassays and expression of CD16 and CD25 proteins by flow cytometry. Low NK activity in the elderly was associated with decline of full health, lowered serum concentration of IL2 and increased production of TNFalpha during NK reaction. Inhibition of TNFalpha activity by anti-TNF monoclonal antibody suppressed exclusively NK activity of low NK responders. Moreover, stimulation in vitro of blood mononuclear cells, with TNFalpha induced in the elderly low NK responders a significantly higher increase of the CD25 expression on the surface of NK cells as compared with that in the elderly high responders. Since the CD25 molecule constitutes a subunit of the high affinity receptor, binding IL2 to immunocompetent cells, its increased expression on NK cells of low NK responders would enable them to bind even low amounts of the endogenous IL2 available in this group of the elderly. Thus, an overproduction of TNFalpha seems to be a mechanism compensating, in the non-fully healthy elderly, for the decreased IL2 production, promoting efficient cytotoxic reaction.
9

The susceptibility to apoptosis of natural killer [NK] cells in elderly individuals with low and high levels of NK cytotoxic activity

81%
Szmit E., Trzonkowski P., Mysliwska J., Mysliwski A.
Cellular and Molecular Biology Letters
|
2002
|
tom 07
|
nr Suppl.
10

Anti-tumor action of tumor necrosis factor against Bomirski Ab melanoma in hamsters

81%
Koszalka P., Szmit E., Mysliwski A., Bigda J.
Archivum Immunologiae et Therapiae Experimentalis
|
2007
|
tom 55
|
nr 4
11

The effect of angiogenesis inhibitor TNP-470 on the blood vessels of the lungs, kidneys and livers of treated hamsters

81%
Mysliwski A., Kubasik-Juraniec J., Koszalka P., Szmit E.
Folia Morphologica
|
2004
|
tom 63
|
nr 1
The growth of solid tumours and their metastases is dependent on the development of new blood vessels (angiogenesis). Therefore angiogenesis inhibitors are potential antitumour drugs. In our previous studies it was found that the angiogenesis inhibitor TNP-470 given to transplantable melanoma-bearing hamsters can decrease the rate of the tumour growth, although the survival time of the animals treated was not significantly affected. It was found finally that TNP-470 given in the vicinity of the growing tumour can cause complete remission of the melanoma in hamsters treated in this way. To check what side-effects could be evoked by such treatment, an examination of the morphology of the blood vessels of the lungs, kidneys and livers of the treated animals was carried out. It was found that the angiogenesis inhibitor applied did not cause any changes which could be observed by light and electron microscopes in the structure of the examined blood vessels of the treated animals.
12

The effects of galactosamine on UTP levels in the livers of young, adult and old rats

81%
Kmiec Z., Smolenski R. T., Zych M., Mysliwski A.
Acta Biochimica Polonica
|
2000
|
tom 47
|
nr 2
Galactosamine (GalN), a well-known hepatotoxin that depletes the cellular pool of uracil nucleotides, was previously shown to have greater impact on the inhibition of protein synthesis in hepatocytes of old rats as compared with young animals (Kmiec 1994, Ann. N.Y. Ac. Sci. 717, 216-225). In the present study we compared the effects of GalN on the nucleotide content (measured by ion-exchange HPLC) in the livers of young (4 months), adult (12 months), and old (24-26 months old) rats two hours after its intraperitoneal administration. UTP content of the livers of old control rats was significantly lower (by 28%) than that of young animals. GalN administration decreased the UTP content in the livers of young, adult and old rats by, respectively, 55%, 65% and 89%, and increased the content of UDP-sugars by 189%, 175% and 305%. The hepatic content of ATP, ADP, AMP, NAD, GTP except CTP did not differ significantly among the age groups of rats studied, and was not changed by GalN treatment. The content of CTP was significantly higher in old rats (P < 0.03) upon GalN treatment. The lower hepatic content of UTP may partially explain the increased sensitivity of hepatocytes and livers of old rats to the action of galactosamine, and pos­sibly to other hepatotoxic compounds that decrease transcription in the liver.
13

The corticotropin-releasing hormone modulates the NF-kappaB pathway in the keratinocytes

81%
Zbytek B., Slominski A., Mysliwski A.
Cellular and Molecular Biology Letters
|
2002
|
tom 07
|
nr Suppl.
14

The correlation between NK cytotoxic activity and the production of the proinflammatory cytokines during the ageing process

81%
Bryl E., Mysliwska J., Foerster J., Mysliwski A.
Folia Histochemica et Cytobiologica
|
1997
|
tom 35
|
nr 2
15

Komorki macierzyste krwi pepowinowej

80%
Stolarek M., Mysliwski A.
Postępy Biologii Komórki
|
2005
|
tom 32
|
nr 2
375-390
16

26 kD TNFalpha precursor molecule and 17 kD mature TNFalpha form differentiate the clinical status of the patients with ling-standing diabetes mellitus of type I

71%
Zorena K., Mysliwska J., Semetkowska-Jurkiewicz E., Lukaszuk K., Mysliwski A.
Folia Histochemica et Cytobiologica
|
1997
|
tom 35
|
nr 2
17

CD4plus CD25plus T regulatory cells decrease the cytotoxicity of CD8 HIGHplus T lymhocytes but not that of NK cells against the antigens of the anti-influenza vaccine

71%
Trzonkowski P., Szmit E., Mysliwska J., Dobyszuk A., Mysliwski A.
Cellular and Molecular Biology Letters
|
2002
|
tom 07
|
nr Suppl.
18

Thyroid C cell function during fasting and refeeding of young and old rats

71%
Kmiec Z., Kotlarz G., Mysliwski A., Wyrzykowska M., Pokrywka L.
Folia Histochemica et Cytobiologica
|
2002
|
tom 40
|
nr 2
19

The atypical pattern of cell death in B16F10 melanoma cells treated with TNP-470

71%
Okroj M., Stawikowska D., Slominska E. M., Mysliwski A., Bigda J.
Cellular and Molecular Biology Letters
|
2006
|
tom 11
|
nr 3
TNP-470 is an acknowledged anti-angiogenic factor, and was studied clinically as an anti-cancer drug. We previously reported on an additional property of this molecule: the intracellular generation of reactive oxygen species in B16F10 melanoma cells. We showed that a massive generation of ROS occurred in the first few hours after treatment with TNP-470 and that this event was critical to subsequent cell death. In this study, we analyzed the process of cell death and noticed an atypical pattern of death markers. Some of these, such as DNA fragmentation or condensation of chromatin, were characteristic for programmed cell death, while others (the lack of phosphatidylserine flip-flop but permeability to propidium iodide, the maintenance of adhesion to the substratum, no change in mitochondrial transmembrane potential, no effect of the panspecific caspase inhibitor) rather suggested a necrotic outcome. We concluded that TNP-470 induced at least some pathways of programmed cell death. However, increasing damage to critical cell functions appears to cause a rapid switch into the necrotic mode. Our data is similar to that in other reports describing the action of ROS-generating agents. We hypothesize that this rapid programmed cell death/necrosis switch is a common scenario following free radical stress.
20

Studies of leptin receptors expression in the hypothalamus fasted and refed young and old rats

61%
Kotlarz G., Mlotkowska M., Kmiec Z., Hinc K., Kubasik-Juraniec J., Mysliwski A.
Acta Biochimica Polonica
|
2006
|
tom 53
|
nr Supplement 1
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