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Cardioprotection of exogenous erythropoietin in mice with ligature-induced aortic stenosis: effects on maladaptive cardiac hypertrophy

100%

Zheng L., Xu J., Qiu W., Liu X., Zhao C.-M., Chen D., Chen Y.

Journal of Physiology and Pharmacology

2010

tom 61

nr 1

13-20

Pre-operative treatment with recombinant human erythropoietin may improve aortic stenosis patients' condition, including anemia and/or cardiac dysfunction, for subjecting to aortic valve replacement. In this study, we tested this hypothesis in a mouse model of aortic stenosis. Adult male mice were subjected to either aortic stenosis created by aortic ligature or sham operation. Aortic stenosis for 4 weeks caused cardiac hypertrophy, pulmonary congestion and left ventricular dysfunction. It was associated with increased levels of tumor necrosis factor-a in serum and myocardium, and reduced levels of interleukin-10 in myocardium but not in serum. Mytocyte apoptosis rate, level of cleaved caspase 3, activity of nuclear factor-B and expression of p38-MAPK pathway were also elevated. Erythropoietin treatment increased hematocrit but did not prevent the development of cardiac hypertrophy. It, however, reduced the apoptosis, prevented the increases in tumor necrosis factor-, nuclear factor-B activation and phosphorylation of p38, and attenuated the increases in lung weight, the decreases in LVEF and LVFS, and the increases in LVDd and LVDs. In conclusion recombinant human erythropoietin has cardioprotective effects in maladaptive cardiac hypertrophy by inhibiting nuclear factor-B activation, phosphorylation of p38-MAPK pathway, and production of tumor necrosis factor-, together leading to a reduced apoptosis.

Feeding behavior and body weight development: lessons from rats subjected to gastric bypass surgery or high-fat diet

100%

Furnes M. W., Zhao C.-M., Stenstrom B., Arum C.-J., Tommeras K., Kulseng B., Chen D.

Journal of Physiology and Pharmacology. Supplement

2009

tom 60

nr 7

Serum gastrin and gastric enterochromaffin-like cells during estrous cycle, pregnancy and lactation, and in response to estrogen-like agents in rats

100%

Vigen R. A., Chen D., Syversen U., Stunes K., Hakanson R., Zhao C.-M.

Journal of Physiology and Pharmacology

2011

tom 62

nr 3

Histamine-containing enterochromaffin-like (ECL) cells are numerous in the gastric mucosa. They operate under the control of gastrin. ECL-cell tumors (gastric carcinoids) may arise as a consequence of sustained hypergastrinemia. For reasons unknown, such tumors have a female preponderance both in laboratory animals and humans. The present study consisted of four experiments exploring the possibility that gender-related factors might affect rat ECL cells. 1) A gender difference in terms of serum gastrin concentration and oxyntic mucosal histidine decarboxylase (HDC) activity appeared in Sprague-Dawley but not Wistar rats. Ultrastructural appearance of the ECL cells did not differ between genders. 2) During the different phases of the estrous cycle, the serum gastrin concentration, HDC activity and histamine concentration did not change. 3) During pregnancy, the serum gastrin concentration was suppressed, while it was increased during lactation. The HDC activity and the histamine concentration of the oxyntic mucosa were correlated with the levels of circulating gastrin. 4) Twelve-month treatment with estrogen-like agents, dieldrin and/or toxaphene (alone or in combination) was without any effect on the ECL cells neither in male nor in female rats. In conclusion, the ECL cells are under the control of gastrin, but probably not hormones that involve in the estrous cycle and pregnancy and lactation in rats. Possible gender-related factors behind the female preponderance of ECL-cell tumors remain unknown.

Ograniczanie wyników

2 Journal of Physiology and Pharmacology

1 Journal of Physiology and Pharmacology. Supplement

3 Chen D.

3 Zhao C.-M.

1 Arum C.-J.

1 Chen Y.

1 Furnes M. W.

1 Hakanson R.

1 Kulseng B.

1 Liu X.

1 Qiu W.

1 Stenstrom B.

1 Stunes K.

1 Syversen U.

1 Tommeras K.

1 Vigen R. A.

1 Xu J.

1 Zheng L.

1 2011

1 2010

1 2009

Wyniki wyszukiwania

Cardioprotection of exogenous erythropoietin in mice with ligature-induced aortic stenosis: effects on maladaptive cardiac hypertrophy

Feeding behavior and body weight development: lessons from rats subjected to gastric bypass surgery or high-fat diet

Serum gastrin and gastric enterochromaffin-like cells during estrous cycle, pregnancy and lactation, and in response to estrogen-like agents in rats