Wyniki wyszukiwania

1

Estimation of the rate of coronary arterial collateral blood flow during acute myocardial ischemia

100%

Phitzner R., Sendur R., Wcislo W.

Acta Physiologica Polonica

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1979

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tom 30

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nr 1

2

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Effect of stimulation of the vaagus nerves and vagotomy on myoelectric activity of small bowel

100%

Thor P. J., Sendur R., Laskiewicz J.

Acta Physiologica Polonica

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1989

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tom 40

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nr 2

Thor, P. J. Sendur, R. and Laskiewicz, J.: Effect of stimulation of the vagus nerves and vagotomy on myoelectric activity of small bowel. Acta Physiol. Pol., 1989, 40 (2): 255-261. Experiments have been done on conscious dogs (6 animals) to study vagal 'influences on small bowel motility. First group (3 dogs) was prepared with gastric and esophageal fistulas, the second group (3 dogs) with gastric fistulas. Both groups had mono- polar silver electrodes placed along small bowel. Stimulation of vagus with sham feeding (SF) increased MMC period of about 21°/o. Insulin and 2DG infused intravenously increased MMC period at lower dose Tange and in high doses induced fed-like pattern of motility. Supradiaphragmatic vagotomy done in the second group animals does not change significantly fasted as well as fed motility pattern. These data suggest that central and peripheral vagal input is required for inhibition MMC activity and development fed motility pattern.

3

Nitric oxide as mediator of bradykinin-induced pancreatic circulatory and metabolic responses

100%

Pawlik W. W., Sendur R., Biernat J., Koziol R.

Journal of Physiology and Pharmacology

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1997

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tom 48

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nr 4

4

Role of nitric oxide in the pancreatic vascular and metabolic responses associated with activation of capsaicin-sensitive neurons

100%

Pawlik W. W., Czarnobilski K., Sendur R., Konturek S. J.

Journal of Physiology and Pharmacology

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1996

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tom 47

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nr 4

5

Effects of substance P on intestinal circulation and oxygen consumption

88%

Pawlik W. W., Gustaw P., Czarnobilski K., Sendur R., Konturek S. J.

Acta Physiologica Polonica

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1987

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tom 38

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nr 5

6

Role of calcitonin gene related peptide in the modulation of intestinal circulatory, metabolic and myoelectric activity during ischemia-reperfusion

88%

Pawlik W. W., Obuchowicz R., Biernat J., Sendur R., Jaworek J.

Journal of Physiology and Pharmacology

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2000

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tom 51

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nr 4,2

7

Nitric oxide is involved in the mediation of gastric blood flow and tissue oxygenation

88%

Gustaw P., Pawlik W. W., Czarnobilski K., Sendur R., Konturek S. J.

Journal of Physiology and Pharmacology

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1994

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tom 45

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nr 3

8

Role of capsaicin-sensitive neurons in the control of intestinal blood flow and oxygen uptake

88%

Gustaw P., Pawlik W. W., Jacobson E. D., Sendur R., Konturek S. J.

Journal of Physiology and Pharmacology

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1995

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tom 46

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nr 1

9

Stimulation of sensory nerves and CGRP administration attenuates development pancreatitis evoked by ischemia-reperfusion

76%

Warzecha Z., Dembinski A., Ceranowicz P., Sendur R., Pawlik W. W., Konturek S. J.

Journal of Physiology and Pharmacology. Supplement

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2001

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tom 52

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nr 2

10

Role of afferent nerves and sensory peptides in the mediation of hepatic artery buffer response

76%

Biernat J., Pawlik W. W., Sendur R., Dembinski A., Brzozowski T., Konturek S. J.

Journal of Physiology and Pharmacology

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2005

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tom 56

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nr 1

Intrahepatic arteries are richly innervated by both adrenergic and sensory vanilloid-sensitive (capsaicin-sensitive) fibers. Stimulation of capsaicin sensitive fibers has been shown to dilate the intrahepatic vessels by both releasing sensory neuropeptides and by modulating the adrenergic tone. However the participation of capsaicin-sensitive fibers in the mediation of the hepatic artery buffer response (HABR) has not been investigated yet. To explore the involvement of sensory innervation and sensory neuropeptides in the HABR, the experiments were performed on capsaicin-denervated Wistar rats. In addition, we used selective CGRP and tachykinin receptor antagonists to test the participation of CGRP, substance P and NK-A in HABR in the rat. In anesthetized rats the hepatic artery blood flow (HABF), microcirculatory hepatic blood flow (HBF) and portal blood flow (PBF) were determined. The HABR was induced by partial occlusion of the portal vein and maintaining the PBF at 10% of its control preocclusive value. In the control HABR the hepatic artery blood flow increased by 89% (p< 0.005) whilst the HBF at the same time decreased by 32% (p< 0.005) in comparison to preocclusive HABF and HBF values. In sensory-denervated rats the resting HBF and PBF were increased by 23% (p< 0.05) and 34% (p< 0.05), respectively in comparison to the control HBF and PBF values. In this group the induction of the HABR increased the hepatic artery blood flow by only 55% (p< 0.05), whilst the HBF was reduced by 45% (p< 0.05). Pretreatment with CGRP 8-37 (CGRP receptor antagonist) and NK-1 but not NK-2 nor NK-3 receptor antagonists significantly reduced the HABF by 43% (p< 0.05) and 25 % (p< 0.05) as compared to the HABF value in the control HABR group. These findings support the hypothesis that the hepatic artery buffer response induced by reduction of the portal inflow to the liver by 90% is partially mediated by activation of capsaicin-sensitive sensory fibers in the liver, probably due to local tissue ischemia and hypoxia. The observed vasodilation in the vascular bed of the hepatic artery is due to stimulation of CGRP and NK-1 receptors.

11

Sensory neurons and liver protection

76%

Biernat J., Sendur R., Obuchowicz R., Jaworek J., Zejc-Bajsarowicz M., Pawlik W. W.

Journal of Physiology and Pharmacology. Supplement

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2001

|

tom 52

|

nr 2

12

Myelectric bowel activity in ischemia-reperfusion damage. Role of sensory neurons

76%

Pawlik W. W., Thor P., Sendur R., Biernat J., Koziol R., Wasowicz P.

Journal of Physiology and Pharmacology

|

1998

|

tom 49

|

nr 4

13

Role of tachykinins in the control of pancreatic secretion and circulation

76%

Pawlik W. W., Konturek S. J., Gustaw P., Czarnobilski K., Sendur R., Jaworek J., Yanaihara N.

Journal of Physiology and Pharmacology

|

1992

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tom 43

|

nr 1

Tachykinins (TK) are family of peptides including substance P (SP), substance K (SK) and neuromedin K (NK) that have been found in the nerves of the gastrointestinal tract and proposed to act as neurotransmitters to affect the motor, secretory and circulatory functions of the gut, but little is known about their action on the pancreas. In this study three series of tests were carried out to determine the action of SP, SK and NK on pancreatic secretion in conScious dogs and amylase release from the dispersed rat pancreatic acini and to correlate the alterations in pancreatic secretory and circulatory effects of TK in anesthetized dogs. SP, SK and NK infused i. v. in graded doses (0.12-1.0 µg/kg per h) in conscious dogs stimulated pancreatic protein outputs reaching, respectively, 38% and 23% of the maximal response to CCK (40 pmol/kg per h). HCO₃ outputs were also significantly increased but the highest response did not exceed about 5% of secretin (328 pmol/kg per h) maximum. Cholinergic blockade by atropine abolished the pancreatic responses to tachykinins. When added at various concentrations (10⁻¹¹ -10⁻⁷ M) to the incubation medium of rat dispersed pancreatic acini, SK, SP and NK increased in concentration-dependent manner the release of amylase from the resting pancreatic acini and augmented the enzyme release induced by CCK-8 and by urecholine. In anesthetized dogs infused with a background dose of secretin (82 pmol/kg per h), addition of SP, SK and NK caused an immediate and dose-dependent increase in the pancreatic blood flow, oxygen consumption and pancreatic secretion accompanied by a dose-dependent decrease in arterial blood pressure. This study shows that TK are potent pancreatic circulatory stimulants and moderate secretagogues both in vivo and in vitro, acting, at least in part, via cholinergic pathway.

14

Sensory nerves as modulators of intestinal preconditioning

76%

Obuchowicz R., Pawlik M., Sendur R., Szczepanski W., Biernat J., Pawlik W. W.

Journal of Physiology and Pharmacology. Supplement

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2001

|

tom 52

|

nr 2

15

CGRP as mediator of circulatory and myoelectric changes observed in the small intestine subjected to ischemia and reperfusion [I-R]

76%

Sendur R., Biernat J., Obuchowicz R., Gajda M., Dembinski A., Warzecha Z., Pawlik W. W.

Journal of Physiology and Pharmacology. Supplement

|

2001

|

tom 52

|

nr 2

16

Microcirculatory and motor effects of endogenous nitric oxide in the rat gut

76%

Pawlik W. W., Gustaw P., Thor P., Sendur R., Czarnobilski K., Hottenstein O. D., Konturek S. J.

Journal of Physiology and Pharmacology

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1993

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tom 44

|

nr 2

17

Histamine H3 receptors modulate reactive hyperemia in rat gut

76%

Pawlik W. W., Obuchowicz R., Pawlik M. W., Sendur R., Biernat J., Brzozowski T., Konturek S. J.

Journal of Physiology and Pharmacology

|

2004

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tom 55

|

nr 3

Reactive hyperemia (RH) is an abrupt blood flow increase following release from mechanical occlusion of an artery, with restoration of intra-arterial pressure. The mechanism of this postocclusion increase in blood flow in the gut is multifactorial. Relaxation of intestinal resistance vessels, observed during RH, may involve myogenic, metabolic, hormonal and neurogenic factors. Evidence exists that histamine is an important endogenous mediator of various functions of the gut, including blood flow. The vascular effects of histamine in the intestinal circulation are due its agonistic action on histamine H1, H2 and H3 receptors. In the present study the hypothesis was tested that peripheral histamine H3 receptors are involved in the mediation of RH in the intestinal circulation. In anesthetized rats, anterior mesenteric artery blood flow (MBF) was determined with ultrasonic Doppler flowmeter, and arterial pressure (AP) was determined with a transducer. The increase in the volume of blood accumulating during RH (RH-volume), the peak increase of arterial blood flow (RH-peak response) and the duration of the hyperemia (RH-duration) were used to quantify RH after occluding the anterior mesenteric artery for 30, 60 and 120 s. Hyperemia parameters were determined before and after administration of the selective histamine H3 receptor antagonist clobenpropit. Pretreatment with clobenpropit was without any effect on control MBF and AP but significantly reduced most of RH responses. These findings support the hypothesis that histamine H3 receptors do not play any role in the control of intestinal vasculature at basal conditions but these receptors participate in the intestinal hyperemic reaction in response to complete temporal intestinal ischemia.

18

Pretreatment with obestatin inhibits the development of cerulein-induced pancreatitis

64%

Ceranowicz P., Warzecha Z., Dembinski A., Cieszkowski J., Dembinski M., Sendur R., Kusnierz-Cabala B., Tomaszewska R., Kuwahara A., Kato I.

Journal of Physiology and Pharmacology

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2009

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tom 60

|

nr 3

95-101

Obestatin is a peptide derived from the proghrelin, a common prohormone for ghrelin and obestatin. Obestatin, like the ghrelin has been originally extracted from rat stomach, and the stomach seems to be a major source of circulating obestatin. Previous studies have shown that administration of ghrelin exhibits protective effect in the pancreas, inhibiting the development of acute pancreatitis. Recent study has shown that obestatin promotes survival of ß-cells and pancreatic islets. Aim of the present study was to investigate the influence of obestatin administration on the development of cerulein-induced pancreatitis. Studies were performed on male Wistar rats. Acute pancreatitis was induced by cerulein given intraperitoneally 5 times at a dose of 50 µg/kg/dose with 1-h intervals. Obestatin was injected twice intraperitoneally at the dose of 4, 8 or 16 nmol/kg/dose. In control saline-treated rats, obestatin was without effect on pancreatic morphology, serum activity of pancreatic enzymes, serum level of pro-inflammatory interleukin-1b or pancreatic cells proliferation. In animals with induction of acute pancreatitis, morphological examination showed that administration of obestatin decreased pancreatic leukocyte infiltration and vacuolization of acinar cells. These effects were accompanied by reduction in the pancreatitis-evoked increase in serum level of pancreatic digestive enzymes, lipase amylase and poly-C ribonuclease. Obestatin administered at the highest dose of 16 nmo/kg/dose reduced serum activity of these enzymes by 33, 42 and 44%, respectively. Also serum concentration of pro-inflammatory interleukin-1ß was decreased by obestatin in rats with acute pancreatitis; whereas the pancreatitis-evoked decrease in pancreatic blood flow and pancreatic DNA synthesis was partially reversed. Administration of obestatin reduces the severity of cerulein-induced acute pancreatitis. This effect is related, at least in part, to the improvement of pancreatic blood flow and reduction in pro-inflammatory interleukin-1ß release.

19

Treatment with ghrelin accelerates the healing of acetic acid-induced gastric and duodenal ulcers in rats

64%

Ceranowicz P., Warzecha Z., Dembinski A., Sendur R., Cieszkowski J., Ceranowicz D., Pawlik W. W., Kuwahara A., Kato I., Konturek P. C.

Journal of Physiology and Pharmacology

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2009

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tom 60

|

nr 1

87-98

Recent studies have shown that ghrelin exhibits gastroprotective effects. The aim of present study was to examine the influence of ghrelin administration on the healing of chronic gastric and duodenal ulcers and to evaluate the role of growth hormone (GH) and insulin-like growth factor-1 (IGF-1) in this process. In pituitary-intact or hypophysectomized rats, chronic gastric and duodenal ulcers were induced by acetic acid. After induction of ulcers, rats were treated intraperitoneally twice a day with saline, ghrelin (4, 8 or 16 nmol/kg/dose) or IGF-1 (20 nmol/kg/dose) for six or ten days. In animals with intact pituitary, treatment with ghrelin increased serum level of GH and IGF-1. These effects were accompanied by the increase in mucosal cell proliferation, mucosal blood flow and healing rate of gastric and duodenal ulcers. After hypophysectomy, the significant increase in serum level of endogenous ghrelin was observed, but the healing of gastric and duodenal ulcers was delayed. This effect was accompanied by a significant decrease in serum concentration of endogenous GH and IGF-1, and reduction in mucosal blood flow and DNA synthesis. In hypophysectomized rats, administration of exogenous ghrelin was without any effect on serum level of GH and IGF-1, healing rate of gastroduodenal ulcers or mucosal cell proliferation. In contrast to this effect, administration of IGF-1 increased mucosal cell proliferation, healing rate of gastroduodenal ulcers and mucosal blood flow in hypophysectomized rats. Conclusion: Treatment with ghrelin accelerates healing of chronic gastroduodenal ulcers and this effect is mediated by the release of endogenous GH and IGF-1.

20

Heparin inhibits protective effect of ischemic preconditioning in ischemia/reperfusion-induced acute pancreatitis

64%

Warzecha Z., Dembinski A., Ceranowicz P., Dembinski M., Sendur R., Cieszkowski J., Sendur P., Tomaszewska R.

Journal of Physiology and Pharmacology

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2012

|

tom 63

|

nr 4

Ograniczanie wyników

Estimation of the rate of coronary arterial collateral blood flow during acute myocardial ischemia

Effect of stimulation of the vaagus nerves and vagotomy on myoelectric activity of small bowel

Nitric oxide as mediator of bradykinin-induced pancreatic circulatory and metabolic responses

Role of nitric oxide in the pancreatic vascular and metabolic responses associated with activation of capsaicin-sensitive neurons

Effects of substance P on intestinal circulation and oxygen consumption

Role of calcitonin gene related peptide in the modulation of intestinal circulatory, metabolic and myoelectric activity during ischemia-reperfusion

Nitric oxide is involved in the mediation of gastric blood flow and tissue oxygenation

Role of capsaicin-sensitive neurons in the control of intestinal blood flow and oxygen uptake

Stimulation of sensory nerves and CGRP administration attenuates development pancreatitis evoked by ischemia-reperfusion

Role of afferent nerves and sensory peptides in the mediation of hepatic artery buffer response

Sensory neurons and liver protection

Myelectric bowel activity in ischemia-reperfusion damage. Role of sensory neurons

Role of tachykinins in the control of pancreatic secretion and circulation

Sensory nerves as modulators of intestinal preconditioning

CGRP as mediator of circulatory and myoelectric changes observed in the small intestine subjected to ischemia and reperfusion [I-R]

Microcirculatory and motor effects of endogenous nitric oxide in the rat gut

Histamine H3 receptors modulate reactive hyperemia in rat gut

Pretreatment with obestatin inhibits the development of cerulein-induced pancreatitis

Treatment with ghrelin accelerates the healing of acetic acid-induced gastric and duodenal ulcers in rats

Heparin inhibits protective effect of ischemic preconditioning in ischemia/reperfusion-induced acute pancreatitis