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1
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Effects of pioglitazone and high-fat diet on ceramide metabolism in rat skeletal muscles

100%
Zendzian-Piotrowska M., Baranowski M., Zabielski P., Gorski J.
Journal of Physiology and Pharmacology. Supplement
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2006
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tom 57
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nr 10
101-114
Ceramide is involved in the pathogenesis of insulin resistance in skeletal muscles of humans and rodents. However, there are conflicting reports in the literature on the effect of thiazolidinediones (a new class of insulin sensitizing drugs) on skeletal muscle ceramide content. Therefore, the aim of our study was to examine the effect of pioglitazone on the level of ceramide and its metabolites and on the activity of the key enzymes of ceramide metabolism in different skeletal muscle types of the rat. The experiments were carried out on rats fed either a standard chow or a high-fat diet for 21 days. Each group was divided into two subgroups: control and treated with pioglitazone for 14 days. High-fat diet increased the content of ceramide in the soleus and in the red section of the gastrocnemius, but not in the white section of the latter. The activity of neutral Mg2+-dependent sphingomyelinase and acid sphingomyelinase was simultaneously reduced in all examined muscles. Administration of pioglitazone decreased ceramide level in the soleus and in the red section of the gastrocnemius in rats fed either diet. This effect could not be attributed to decreased rate of ceramide formation from sphingomyelin or to its augmented deacylation to sphingosine. Pioglitazone treatment reduced the concentration of plasma free fatty acids in rats fed on either diet. Therefore, we conclude that the drug decreased the muscle content of ceramide by reducing its de novo synthesis. The results of our study indicate that reduction in ceramide level may be one of the mechanisms by which pioglitazone improves skeletal muscle insulin sensitivity.
2

Warunki termostabilności i charakterystyka katalityczna dehydrogenazy izocytrynianowej z Bacillus licheniformis

100%
Zabielski P., Strumilo S., Swiecicka I.
Biotechnologia
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2001
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nr 3
3

The effect of fat rich diet on ceramide level and enzymes activity of ceramide metabolism in the rat skeletal muscle

100%
Blachnio A., Baranowski M., Zabielski P., Gorski J.
Acta Biochimica Polonica
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2006
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tom 53
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nr Supplement 1
4
Content available remote

PPARalpha agonist induces the accumulation of ceramide in the heart of rats fed high-fat diet

100%
Baranowski M., Blachnio A., Zabielski P., Gorski J.
Journal of Physiology and Pharmacology
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2007
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tom 58
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nr 1
It was shown that high-fat feeding of mice with cardiac-specific overexpression of peroxisome proliferator-activated receptor (PPAR) alpha but not wild type animals leads to the accumulation of ceramide (an important mediator of lipotoxicity) in the heart [Finck et al. 2003 Proc Natl Acad Sci USA]. To investigate the mechanism of this phenomenon we examined the effects of PPARalpha activation on ceramide metabolism in the myocardium. Male Wistar rats were fed either a standard chow or a high-fat diet. Each group was divided into two subgroups: control and treated with selective PPARalpha activator – WY-14643. In the rats fed on the standard diet WY-14643 did not affect the myocardial content of sphingomyelin and ceramide but reduced the content of sphinganine and sphingosine. It also inhibited the activity of neutral sphingomyelinase and increased the activity of acid sphingomyelinase, whereas the activity of ceramidases and serine palmitoyltransferase (SPT) remained stable. High-fat diet itself did not affect the content of the examined sphingolipids. However, it reduced the activity of sphingomyelinases and ceramidases having no effect on the activity of SPT. Administration of WY-14643 to this group significantly increased the content of myocardial free palmitate, ceramide, sphingomyelin and the activity of SPT. Our results demonstrated that PPARalpha activation modulates myocardial ceramide metabolism and leads to the accumulation of ceramide in the heart of the high-fat fed rats due to its increased synthesis de novo.
5
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Effect of tachycardia on mRNA and protein expression of the principal components of the lipolytic system in the rat's heart ventricles

88%
Wojcik B., Miklosz A., Zabielski P., Chabowski A., Gorski J.
Journal of Physiology and Pharmacology
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2017
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tom 68
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nr 5
6
Content available remote

Effect of tachycardia on lipid metabolism and expression of fatty acid transporters in heart ventricles of the rat

88%
Wojcik B., Harasim E., Zabielski P., Chabowski A., Gorski J.
Journal of Physiology and Pharmacology
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2015
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tom 66
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nr 5
7
Content available remote

Liver X receptor agonist T0901317 enhanced peroxisome proliferator-activated receptor-delta expression and fatty acid oxidation in rat skeletal muscle

76%
Baranowski M., Blachnio-Zabielska A. U., Zabielski P., Harasim E., Harasiuk D., Chabowski A., Gorski J.
Journal of Physiology and Pharmacology
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2013
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tom 64
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nr 3
8
Content available remote

Effect of acute exercise on mRNA and protein expression of main components of the lipolytic complex in different skeletal muscle types in the rat

76%
Miklosz A., Baranowski M., Lukaszuk B., Zabielski P., Chabowski A., Gorski J.
Journal of Physiology and Pharmacology
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2019
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tom 70
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nr 3
9
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The development of cigarette smoke induced chronic pancreatitis in mice is associated with increased expression of K-Ras and NF-κB

52%
Daniluk J., Daniluk U., Rogalski P., Swidnicka-Siergiejko A., Wasielica-Berger J., Jacek Kucharski J. R., Antonowicz S., Reszec J., Lotowska J. M., Zabielski P., Blachnio-Zabielska A., Dabrowski A.
Annals of Agricultural and Environmental Medicine
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2022
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tom 29
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nr 2
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