Wyniki wyszukiwania

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Blockade of 5-HT1A receptors in the phrenic nucleus of the rat attenuated raphe induced activation of the phrenic nerve activity

100%

Pecotic R., Dogas Z., Valic Z., Valic M.

Journal of Physiology and Pharmacology

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2009

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tom 60

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nr 3

167-172

Stimulation of the raphe pallidus nucleus produces facilitatory effects on respiratory activity. Numerous serotonergic projections from the raphe pallidus have been shown to terminate in the phrenic nucleus. This study was undertaken to examine the role of 5-hydroxytryptamine 1A (5-HT1A) receptors in the phrenic nucleus on the excitatory response of the phrenic nerve activity elicited from the raphe pallidus. We hypothesized that blockade of 5-HT1A receptors in the phrenic nucleus will attenuate raphe-induced facilitation of the phrenic nerve. Chemical stimulation of the raphe pallidus by synaptic excitant D,L-homocysteic acid produced increase in the amplitude of the phrenic nerve activity. After microinjection of the specific 5-HT1A receptor antagonist WAY, N-(2-(4,2-methoxyphenyl)-1-piperazinyl)ethyl)-N-2-pyridinyl-cyclohexane-carboxamide maleate into the phrenic nucleus, the raphe-induced facilitation of the phrenic nerve was attenuated. These data suggest that excitation of the phrenic nerve activity elicited by activation of the neurons in the raphe pallidus is mediated by 5-HT1A receptors in the phrenic nucleus.

2

Phrenic nerve activity is enhanced by 5-HT1A receptor agonist 8-OH-DPAT in spontaneously breathing anesthetized rats

100%

Valic M., Pecotic R., Dogas Z.

Journal of Physiology and Pharmacology

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2008

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tom 59

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nr 1

Activation of serotonin 1A (5-HT1A) receptors has been shown to have diverse effects on respiration. The purpose of this study was to determine changes in respiratory motor pattern of phrenic nerve activity and respiratory rhythm after systemic application of specific 5-HT1A receptor agonist 8-hydroxy-2-di-n-propylamino-tetralin (8-OH-DPAT). We hypothesized that systemic application of specific 5-HT1A receptor agonist 8-OH-DPAT in spontaneously breathing anaesthetized rats will enhance phrenic motor output and phrenic respiratory rate. The study was performed in spontaneously breathing urethane anesthetized rats. Intravenous application of 8-OH-DPAT produced dose dependent increase in the amplitude of integrated phrenic nerve activity and disturbances in respiratory rhythm. Stimulating effect of 8-OH-DPAT on phrenic nerve activity was abolished by intravenous application of the selective 5-HT1A receptor antagonist WAY, N-(2-(4,2-methoxyphenyl)-1-piperazinyl)ethyl)-N-2-pyridinyl-cyclohexane-carboxamide maleate (WAY-100635). These results show that stimulation of 5-HT1A receptors by intravenous application of 8-OH-DPAT enhances phrenic nerve activity in spontaneously breathing rats.

3

Hyperoxia blunts renal sympathetic nerve activity response to acute intermittent hypercapnia in rats

88%

Madirazza K., Pecotic R., Pavlinac Dodig I., Valic M., Dogas Z.

Journal of Physiology and Pharmacology

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2019

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tom 70

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nr 5

4

Remifentanil reversibly abolished phrenic long term facilitation in rats subjected to acute intermittent hypoxia

76%

Ivancev B., Carev M., Pecotic R., Valic M., Pavlinac Dodig I., Karanovic N., Dogas Z.

Journal of Physiology and Pharmacology

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2013

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tom 64

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nr 4

Ograniczanie wyników

4 Journal of Physiology and Pharmacology

4 Dogas Z.

4 Pecotic R.

4 Valic M.

2 Pavlinac Dodig I.

1 Carev M.

1 Ivancev B.

1 Karanovic N.

1 Madirazza K.

1 Valic Z.

1 2019

1 2013

1 2009

1 2008

Blockade of 5-HT1A receptors in the phrenic nucleus of the rat attenuated raphe induced activation of the phrenic nerve activity

Phrenic nerve activity is enhanced by 5-HT1A receptor agonist 8-OH-DPAT in spontaneously breathing anesthetized rats

Hyperoxia blunts renal sympathetic nerve activity response to acute intermittent hypercapnia in rats

Remifentanil reversibly abolished phrenic long term facilitation in rats subjected to acute intermittent hypoxia